Recent Insights into Mechanisms Governing Breast Cancer Dormancy
Zhongliu Fangzhi Yanjiu, 2023 Tumor dormancy refers to the status of disseminated cancer cells that remain in a viable yet not proliferating state for a prolonged period. Dormant cells will eventually "re-awake" resume their proliferation, and produce overt metastasis.
MA Lanjing, ZHANG Baihong
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Tumor‐vascular interactions and tumor dormancy [PDF]
APMIS, 2008 Tumor progression is dependent on a number of sequential steps, including initial tumor‐vascular interactions and recruitment of blood vessels (i.e., the angiogenic switch), as well as tumor cells interacting with the surrounding microenvironment and its different components.
George N, Naumov +3 more
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Tumor Dormancy and Interplay with Hypoxic Tumor Microenvironment. [PDF]
Int J Mol Sci, 2019 The tumor microenvironment is a key factor in disease progression, local resistance, immune-escaping, and metastasis. The rapid proliferation of tumor cells and the aberrant structure of the blood vessels within tumors result in a marked heterogeneity in the perfusion of the tumor tissue with regions of hypoxia.
Butturini E +3 more
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The Function of NM23-H1/NME1 and Its Homologs in Major Processes Linked to Metastasis [PDF]
, 2020 International ...
Boissan, Mathieu +6 more
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Mechanisms of Metastatic Tumor Dormancy [PDF]
Journal of Clinical Medicine, 2013 Tumor metastasis can occur years after an apparent cure due to a phenomenon known as metastatic tumor dormancy; in which tumor masses or individual tumor cells are growth restricted for extended periods of time. This period of dormancy is induced and maintained by several mechanisms, including: (1) Tumor microenvironment factors such as cytokine ...
Osisami, Mary, Keller, Evan T.
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Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells [PDF]
, 2016 Two major barriers to cancer immunotherapy include tumor-induced immune suppression mediated by myeloid-derived suppressor cells and poor immunogenicity of the tumor-expressing self-antigens.
Bear, Harry D. +8 more
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Cancer therapeutic potential of combinatorial immuno- and vaso-modulatory interventions [PDF]
, 2015 Currently, most of the basic mechanisms governing tumor-immune system interactions, in combination with modulations of tumor-associated vasculature, are far from being completely understood.
Alfonso, J. C. L. +5 more
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Targeting Immune-Mediated Dormancy: A Promising Treatment of Cancer
Frontiers in Oncology, 2019 Immune-mediated dormancy is when the immune system keeps proliferating tumor cells unchanged, mostly via cytotoxic activity of immune cells. Cancer dormancy, especially immune-mediated dormancy, may be the explanation for tumor refractory and may be ...
Hao-fan Wang +6 more
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TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling [PDF]
, 2013 In patients, non-proliferative disseminated tumour cells (DTCs) can persist in the bone marrow (BM) while other organs (such as lung) present growing metastasis.
Aguirre Ghiso, Julio A. +7 more
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The acceleration of metastases after tumor removal and the paradoxical phenomenon of concomitant tumor resistance [PDF]
, 2018 Although surgical extirpation of tumors is usually clinically recommended, tumor removal may entail an undesired side effect: the risk of accelerating the growth of metastases.
Chiarella, Paula +3 more
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