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Redox Control of the Dormant Cancer Cell Life Cycle
Cells, 2021 Following efficient tumor therapy, some cancer cells may survive through a dormancy process, contributing to tumor recurrence and worse outcomes. Dormancy is considered a process where most cancer cells in a tumor cell population are quiescent with no ...
Bowen Li +5 more
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Tumor dormancy and immunoescape [PDF]
APMIS, 2008 The role of the immune system in tumor dormancy is now well established. In several experimental models it is possible to induce tumor dormancy in immunocompetent hosts by prior immunization against tumor cells. Equilibrium between immune response and tumor cells leads to long‐term tumor dormancy.
openaire +2 more sources
Frontiers in Oncology, 2021 Parathyroid hormone related protein (PTHrP) is a multifaceted protein with several biologically active domains that regulate its many roles in normal physiology and human disease.
Courtney M. Edwards +4 more
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Microchamber Cultures of Bladder Cancer: A Platform for Characterizing Drug Responsiveness and Resistance in PDX and Primary Cancer Cells. [PDF]
, 2017 Precision cancer medicine seeks to target the underlying genetic alterations of cancer; however, it has been challenging to use genetic profiles of individual patients in identifying the most appropriate anti-cancer drugs. This spurred the development of
Dall'Era, Marc A +9 more
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HIGD1A-mediated dormancy and tumor survival [PDF]
Molecular & Cellular Oncology, 2015 Solid tumors contain regions of anoxia that are also glucose deprived. How cancer cells survive such extreme conditions remains unclear. Here, we discuss our recent findings that regulation of hypoxia inducible gene domain family member 1 A (HIGD1A) via epigenetic mechanisms during glucose starvation modulates oxygen consumption and reactive oxygen ...
Kurosh, Ameri, Emin, Maltepe
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Consensus micro RNAs governing the switch of dormant tumors to the fast-growing angiogenic phenotype. [PDF]
PLoS ONE, 2012 Tumor dormancy refers to a critical stage in cancer development in which tumor cells remain occult for a prolonged period of time until they eventually progress and become clinically apparent.
Nava Almog +8 more
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Biology of advanced uveal melanoma and next steps for clinical therapeutics [PDF]
, 2014 Uveal melanoma is the most common intraocular malignancy although it is a rare subset of all melanomas. Uveal melanoma has distinct biology relative to cutaneous melanoma, with widely divergent patient outcomes.
Bastian, BC +17 more
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Microenvironments Dictating Tumor Cell Dormancy [PDF]
, 2012 The mechanisms driving dormancy of disseminated tumor cells (DTCs) remain largely unknown. Here, we discuss experimental evidence and theoretical frameworks that support three potential scenarios contributing to tumor cell dormancy. The first scenario proposes that DTCs from invasive cancers activate stress signals in response to the dissemination ...
Paloma, Bragado +4 more
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Autophagy and Hepatic Tumor Microenvironment Associated Dormancy
Journal of Gastrointestinal Cancer, 2021 The goal of successful cancer treatment is targeting the eradication of cancer cells. Although surgical removal of the primary tumors and several rounds of chemo- and radiotherapy reduce the disease burden, in some cases, asymptomatic dormant cancer cells may still exist in the body. Dormant cells arise from the disseminated tumor cells (DTCs) from the
Yunus Akkoc, Devrim Gozuacik
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Global Dormancy of Metastases Due to Systemic Inhibition of Angiogenesis [PDF]
, 2014 Autopsy studies of adults dying of non-cancer causes have shown that virtually all of us possess occult, cancerous lesions. This suggests that, for most individuals, cancer will become dormant and not progress, while only in some will it become ...
Benzekry, Sébastien +2 more
core +7 more sources