Results 101 to 110 of about 463,193 (304)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

miR-4666-3p and miR-329 Synergistically Suppress the Stemness of Colorectal Cancer Cells via Targeting TGF-β/Smad Pathway

Frontiers in Oncology, 2019
Quiescent caner stem cells are identified as a subpopulation of colon cancer cells in dormant state and possess strong stem-cell like characteristics.
Jun Ye, Jiacai Lei, Qingqing Fang, Yimin Shen, Wenjie Xia, Xiaoge Hu, Qiuran Xu, Hongjun Yuan, Jian Huang, Jian Huang, Chao Ni, Chao Ni, Chao Ni   +12 more
doaj   +1 more source

NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance [PDF]

, 2019
Lack of proper innate sensing inside tumor microenvironment (TME) limits T cell-targeted immunotherapy. NAD(P)H:quinone oxidoreductase 1 (NQO1) is highly enriched in multiple tumor types and has emerged as a promising target for direct tumor-killing ...
Boothman, David A., Fu, Yang-Xin, Han, Chuanhui, Huang, Xiumei, Jiang, Lingxiang, Li, Xiaoguang, Liu, Zhida, Qiao, Jian, Shen, Aijun, Wang, Yang, Zhang, Anli   +10 more
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer [PDF]

, 2017
background: The present study aimed to examine the relationship between tumour invasiveness (T stage), the local and systemic environment and cancer-specific survival (CSS) of patients with primary operable colorectal cancer.
A Chrysanthopoulou, A Huijbers, AJ Munro, B Mlecnik, C Guastadisegni, C S D Roxburgh, CE Dukes, CH Richards, D C McMillan, D Church, D Hanahan, DC McMillan, F Pages, F Pages, FA Sinicrope, G Bindea, GJ Guthrie, H Ueno, H Ueno, H van Wyk, HC van Wyk, ID Nagtegaal, J Edwards, J Galon, J Guinney, J H Park, J Li, JB O'Connell, JH Park, JH Park, JH Park, JH Park, K Birkenkamp-Demtroder, K Klintrup, L De Smedt, LL Gunderson, LS Rozek, MJ Pollheimer, P G Horgan, P Quirke, R Salazar, S Ogino, SA Vayrynen, SS McAllister, T Kantola, VH Koelzer, W De Roock, WE Mesker   +47 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cancer vaccines: uses of HLA transgenic mice compared to genetically modified mice [PDF]

, 2008
Many tumor antigens have been identified that can be targeted by the immune system. Animal models that have been genetically modified to express human HLA molecules instead of their own MHC antigens have shown to be valuable in the discovery of peptides ...
McArdle, SE
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Exploring Prognosis, Tumor Microenvironment and Tumor Immune Infiltration in Hepatocellular Carcinoma Based on ATF/CREB Transcription Factor Family Gene-Related Model

Journal of Hepatocellular Carcinoma, 2023
Honghong Shen,1,* Xianhua Gu,2,* Huiyuan Li,1 Mingyue Tang,1 Xinwei Li,1 Yue Zhang,1 Fang Su,1 Zishu Wang1 1Department of Medical Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu, People’s Republic of China; 2Department of ...
Shen H, Gu X, Li H, Tang M, Li X, Zhang Y, Su F, Wang Z   +7 more
doaj