Results 271 to 280 of about 455,075 (302)

Immune Cell Metabolism in Tumor Microenvironment

2017
Tumor microenvironment (TME) is composed of tumor cells, immune cells, cytokines, extracellular matrix, etc. The immune system and the metabolisms of glucose, lipids, amino acids, and nucleotides are integrated in the tumorigenesis and development. Cancer cells and immune cells show metabolic reprogramming in the TME, which intimately links immune cell
Yongsheng, Li, Yisong Y, Wan, Bo, Zhu
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CCL21 Programs Immune Activity in Tumor Microenvironment

2020
CCL21 promotes immune activity in the tumor microenvironment (TME) by colocalizing dendritic cells (DC) and T cells programing ectopic lymph node architectural structures that correlate with cancer prognosis. Innovative strategies to deliver CCL21 in cancer patients will reactivate the downregulated immune activity in the TME.
Sherven, Sharma, Pournima, Kadam, Steven, Dubinett   +2 more
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Multifunctional Liposomes Remodeling Tumor Immune Microenvironment for Tumor Chemoimmunotherapy

Small Methods, 2023
AbstractIn the treatment of solid tumors, the complex barriers composed of cancer‐associated fibroblasts (CAFs) prevent drug delivery and T cells infiltration into tumor tissues. Although nanocarriers hold great prospects in drug delivery, fibrosis causes the biological barrier and immunosuppressive tumor microenvironment (ITM) that impairs the anti ...
Xinyang Li, Yang Luo, Zhengjie Huang, Yi Wang, Jian Wu, Shaobing Zhou   +5 more
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Immune resistance orchestrated by the tumor microenvironment

Immunological Reviews, 2006
Summary:  It is now little disputed that most if not all cancer cells express antigens that can be recognized by specific CD8+ T lymphocytes. However, a central question in the field of anti‐tumor immunity is why such antigen‐expressing tumors are not spontaneously eliminated by the immune system.
Thomas F, Gajewski, Yuru, Meng, Christian, Blank, Ian, Brown, Aalok, Kacha, Justin, Kline, Helena, Harlin   +6 more
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The tumor immune microenvironment in peritoneal carcinomatosis

2022
One in four patients with colorectal cancer, 40% of gastric cancer patients, and 60% of ovarian cancer patients will develop peritoneal metastases (PM) in the course of their disease. The outcome of patients with widespread PM remains poor with currently available treatments.
Jesse, Demuytere, Sam, Ernst, Judith, van Ovost, Sarah, Cosyns, Wim, Ceelen   +4 more
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Germline Genetic Variation Modulates Tumor Immune Microenvironment

Cancer Discovery, 2021
Abstract Patient genetic background contributed to antitumor immune responses at molecular and cellular levels.
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Tumor microenvironment, immune response and post-radiotherapy tumor clearance

Clinical and Translational Oncology, 2020
Radiotherapy is the treatment of choice for many cancer patients. Residual tumor leads to local recurrence after a period of an equilibrium created between proliferating, quiescent and dying cancer cells. The tumor microenvironment is a main obstacle for the efficacy of radiotherapy, as impaired blood flow leads to hypoxia, acidity and reduced ...
M. I. Koukourakis, A. Giatromanolaki
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Immune-suppressive properties of the tumor microenvironment

Cancer Immunology, Immunotherapy, 2013
Solid tumors are more than an accumulation of cancer cells. Indeed, cancerous cells create a permissive microenvironment by exploiting non-transformed host cells. Thus, solid tumors rather resemble abnormal organs composed of the cancerous cells itself and the stroma providing the supportive framework.
Jýrgen C. Becker, Mads Hald Andersen, David Schrama, Per thor Straten   +3 more
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Cytokines and Immune Response in the Tumor Microenvironment

Journal of Immunotherapy, 2001
SUMMARY: Over the last few decades a wealth of evidence has been gathered on the potential role that the immune system (IS) can play in the fight against cancer. Together with cell surface adhesion molecules, cytokines (CKs) mediate the activities of IS cells.
MOCELLIN, SIMONE, WANG E, MARINCOLA FM
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Immune Response and Tumor Microenvironment

Tumor formation and progression are caused by neoplastic cells, which take advantage of interfere with cellular processes that control growth, survival, and division. New research emphasizes the critical role of the tumor microenvironment (TME) in cancer initiation and metastasis, even though genetic and epigenetic changes are well-known malignant ...
Vivek Pazhamalai, V. T. Thanush, P. Dharshika, Kosireddy Vanitha, Albin Richard, S. S. Meenambiga   +5 more
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