Results 1 to 10 of about 286,914 (163)

Tumor Necrosis Factor Alpha Signaling and Organogenesis [PDF]

Frontiers in Cell and Developmental Biology, 2021
Tumor necrosis factor alpha (TNF-α) plays important roles in processes such as immunomodulation, fever, inflammatory response, inhibition of tumor formation, and inhibition of viral replication.
Kai You, Hui Gu, Zhengwei Yuan, Xuewen Xu, Xuewen Xu   +4 more
doaj   +3 more sources

Tumor necrosis factor-alpha-mediated inflammatory bone loss: Pathogenic mechanisms and therapeutic potential of its inhibitors [PDF]

Tzu Chi Medical Journal
Bone remodeling preserves skeletal integrity through the balanced actions of bone-resorbing osteoclasts and bone-forming osteoblasts, regulated by mechanical, endocrine, and immune signals.
Wen-Ying Lin, Yu-Jen Pan, Kuang-Ting Yeh, Kuei-Ying Su, Kameshwara Kumar Dharini, Ing-Ho Chen, Wen-Tien Wu, Ming-Der Lin, Cheng-Huan Peng   +8 more
doaj   +2 more sources

Tumor necrosis factor-alpha in patients with alopecia areata

Indian Journal of Dermatology, 2011
Background : Alopecia areata (AA) is a common form of localized, nonscarring hair loss. It is characterized by the loss of hair in patches, total loss of scalp hair (alopecia totalis, AT), or total loss of body hair (alopecia universalis, AU).
Emina Kasumagic-Halilovic, Asja Prohic, Semra Cavaljuga   +2 more
doaj   +3 more sources

Tumor necrosis factor-alpha inhibitor treatment for sarcoidosis

Therapeutics and Clinical Risk Management, 2008
José Luis Callejas-Rubio, Lourdes López-Pérez, Norberto Ortego-CentenoUnit of Autoimmune Systemic Diseases, Hospital Clinico San Cecilio, Granada, SpainAbstract: Sarcoidosis is a chronic multisystem disease of unknown ...
José Luis Callejas-Rubio, Lourdes López-Pérez, Norberto Ortego-Centeno   +2 more
doaj   +5 more sources

Glaucomatous neurodegeneration: An eye on tumor necrosis factor-alpha

Indian Journal of Ophthalmology, 2012
Glaucoma, a neurodegenerative disease, is currently being treated by modulation of one of its primary risk factors, the elevated intraocular pressure. Newer therapies that can provide direct neuroprotection to retinal ganglion cells are being extensively
Renu Agarwal, Puneet Agarwal
doaj   +3 more sources

Comparative Analysis of TNF-alpha, TNF-R1, and TNF-R2 in Patients with Low-impact Fractures Due to Osteoporosis [PDF]

Revista Brasileira de Ortopedia, 2023
Objective To analyze the serum levels of TNF-alpha and its TNF-R1 and TNF-R2 receptors in the blood of patients with low-impact fractures due to osteoporosis, comparing between genders and with healthy patients. Methods The present study was conducted
Abel Oliveira Marques Teixeira, Virmondes Rodrigues-Júnior, Bárbara Rocha Rodrigues, Danila Malheiros Souza, Leonardo Franco Pinheiro Gaia, Denise Bertulucci Rocha Rodrigues   +5 more
doaj   +1 more source

Adverse events of tumor necrosis factor alpha inhibitors for the treatment of ankylosing spondylitis: A meta-analysis of randomized, placebo-controlled trials

Frontiers in Pharmacology, 2023
Objective: Tumor necrosis factor alpha inhibitors (TNFi) have shown substantial efficacy in alleviating and treating ankylosing spondylitis (AS). However, the heightened interest is accompanied by concerns over adverse events.
Haihuan Feng, Haihuan Feng, Ying Zhao, Weihong Kuang, Yanping Dai, Xiaobo Cen, Feng Qin, Feng Qin   +7 more
doaj   +1 more source

Epigenetic Regulation of Tumor Necrosis Factor Alpha [PDF]

Molecular and Cellular Biology, 2007
Tumor necrosis factor alpha (TNF-alpha) is a potent cytokine which regulates inflammation via the induction of adhesion molecules and chemokine expression. Its expression is known to be regulated in a complex manner with transcription, message turnover, message splicing, translation, and protein cleavage from the cell surface all being independently ...
K E, Sullivan, A B M, Reddy, K, Dietzmann, A R, Suriano, V P, Kocieda, M, Stewart, M, Bhatia   +6 more
openaire   +2 more sources

Phytochemicals as inhibitors of tumor necrosis factor alpha and neuroinflammatory responses in neurodegenerative diseases

Neural Regeneration Research, 2022
Inflammatory processes and proinflammatory cytokines have a key role in the cellular processes of neurodegenerative diseases and are linked to the pathogenesis of functional and mental health disorders.
Fatemeh Zahedipour, Seyede Atefe Hosseini, Neil C Henney, George E Barreto, Amirhossein Sahebkar   +4 more
doaj   +1 more source

Eicosanoids and tumor necrosis factor-alpha in the kidney [PDF]

Prostaglandins & Other Lipid Mediators, 2012
The thick ascending limb of Henle's loop (TAL) is capable of metabolizing arachidonic acid (AA) by cytochrome P450 (CYP450) and cyclooxygenase (COX) pathways and has been identified as a nephron segment that contributes to salt-sensitive hypertension. Previous studies demonstrated a prominent role for CYP450-dependent metabolism of AA to products that ...
Ferreri, Nicholas R., Hao, Shoujin, Pedraza, Paulina L., Escalante, Bruno, Vio, Carlos P.   +4 more
openaire   +5 more sources