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Tumor Necrosis Factor Alpha Signaling and Organogenesis [PDF]

Frontiers in Cell and Developmental Biology, 2021
Tumor necrosis factor alpha (TNF-α) plays important roles in processes such as immunomodulation, fever, inflammatory response, inhibition of tumor formation, and inhibition of viral replication.
Kai You, Hui Gu, Zhengwei Yuan, Xuewen Xu, Xuewen Xu   +4 more
doaj   +3 more sources

The concentration of tumor necrosis factor alpha in periapical lesions [PDF]

Stomatološki glasnik Srbije, 2014
Introduction. The balance between proinflammatory and anti-inflammatory cytokines plays an important role in the pathogenesis of chronic periapical lesions.
Popović Jelena, Cvetković Tatjana, Džopalić Tanja, Mitić Aleksandar, Nikolić Marija, Barac Radomir, Živković Slavoljub   +6 more
doaj   +4 more sources

Implication of Tumor Necrosis Factor - Alpha in Preeclampsia [PDF]

Applied Medical Informatics, 2008
Introduction: Preeclampsia is an exacerbation of a generalized inflammatory response, physiologically present in the third trimester of pregnancy.Aim: The aim of the study consists in the evaluation of proinflammatory cytokine TNF-α in the context of ...
Dan MIHU, Nicolae COSTIN, Ligia Daniela BLAGA, Septimiu CIUCHINĂ, Raluca Bogdana POP   +4 more
doaj   +2 more sources

Comparative Analysis of TNF-alpha, TNF-R1, and TNF-R2 in Patients with Low-impact Fractures Due to Osteoporosis [PDF]

Revista Brasileira de Ortopedia, 2023
Objective To analyze the serum levels of TNF-alpha and its TNF-R1 and TNF-R2 receptors in the blood of patients with low-impact fractures due to osteoporosis, comparing between genders and with healthy patients. Methods The present study was conducted
Abel Oliveira Marques Teixeira, Virmondes Rodrigues-Júnior, Bárbara Rocha Rodrigues, Danila Malheiros Souza, Leonardo Franco Pinheiro Gaia, Denise Bertulucci Rocha Rodrigues   +5 more
doaj   +1 more source

Soluble tumor necrosis factor receptor 1 and 2 predict outcomes in advanced chronic kidney disease : a prospective cohort study [PDF]

, 2015
Background : Soluble tumor necrosis factor receptors 1 (sTNFR1) and 2 (sTNFR2) have been associated to progression of renal failure, end stage renal disease and mortality in early stages of chronic kidney disease (CKD), mostly in the context of diabetic ...
AS Levey, C Obregon, CL Meuwese, D Aderka, D Aderka, DE Weiner, DV Barreto, EL Knight, Eva Schepers, FI Hawari, Francis Verbeke, G Tripepi, Griet Glorieux, JF Leeuwenberg, JK Pinckard, JM Luna, KJ Van Zee, L Cabal-Hierro, L Nilsson, Leighton R James, M Goicoechea, M Tonelli, M Valgimigli, MA Niewczas, MG Shlipak, MHA Bemelmans, Nathalie Neirynck, PJ Saulnier, Raymond Vanholder, RB Schnabel, S Soriano, S Xanthoulea, SJ Levine, T Gohda, T Kohno, T Ueland, V Panichi   +36 more
core   +21 more sources

Adverse events of tumor necrosis factor alpha inhibitors for the treatment of ankylosing spondylitis: A meta-analysis of randomized, placebo-controlled trials

Frontiers in Pharmacology, 2023
Objective: Tumor necrosis factor alpha inhibitors (TNFi) have shown substantial efficacy in alleviating and treating ankylosing spondylitis (AS). However, the heightened interest is accompanied by concerns over adverse events.
Haihuan Feng, Haihuan Feng, Ying Zhao, Weihong Kuang, Yanping Dai, Xiaobo Cen, Feng Qin, Feng Qin   +7 more
doaj   +1 more source

Phytochemicals as inhibitors of tumor necrosis factor alpha and neuroinflammatory responses in neurodegenerative diseases

Neural Regeneration Research, 2022
Inflammatory processes and proinflammatory cytokines have a key role in the cellular processes of neurodegenerative diseases and are linked to the pathogenesis of functional and mental health disorders.
Fatemeh Zahedipour, Seyede Atefe Hosseini, Neil C Henney, George E Barreto, Amirhossein Sahebkar   +4 more
doaj   +1 more source

Transmembrane tumor necrosis factor alpha attenuates pressure-overload cardiac hypertrophy via tumor necrosis factor receptor 2.

PLoS Biology, 2020
Tumor necrosis factor-alpha (TNF-α) plays an important pathogenic role in cardiac hypertrophy and heart failure (HF); however, anti-TNF is paradoxically negative in clinical trials and even worsens HF, indicating a possible protective role of TNF-α in HF.
Kun Miao, Ling Zhou, Hongping Ba, Chenxi Li, Haiyan Gu, Bingjiao Yin, Jing Wang, Xiang-Ping Yang, Zhuoya Li, Dao Wen Wang   +9 more
doaj   +1 more source

Tumor Necrosis Factor-Alpha and Age-Related Pathologies

Архивъ внутренней медицины, 2020
Modern concepts about the «inflammaging» and the role of subclinical inflammation in various age-associated pathology are described in the review. Particular attention is paid to the tumor necrosis factor-α, a key cytokine that plays an important role in
S. V. Topolyanskaya
doaj   +1 more source

Severe Infliximab-Induced Alopecia and Scalp Psoriasis in a Woman with Crohn’s Disease: Dramatic Improvement after Drug Discontinuation and Treatment with Adjuvant Systemic and Topical Therapies [PDF]

, 2016
Scalp psoriasis with alopecia is a rare cutaneous reaction to tumor necrosis factor alpha antagonists. This reaction often reverses with discontinuation of the offending drug and initiation of topical treatments; however, irreversible hair loss may occur
Jeremy Udkoff, Philip R. Cohen
core   +1 more source