Results 1 to 10 of about 301,716 (118)

Tumor necrosis factor-alpha-mediated inflammatory bone loss: Pathogenic mechanisms and therapeutic potential of its inhibitors [PDF]

Tzu Chi Medical Journal
Bone remodeling preserves skeletal integrity through the balanced actions of bone-resorbing osteoclasts and bone-forming osteoblasts, regulated by mechanical, endocrine, and immune signals.
Wen-Ying Lin, Yu-Jen Pan, Kuang-Ting Yeh, Kuei-Ying Su, Kameshwara Kumar Dharini, Ing-Ho Chen, Wen-Tien Wu, Ming-Der Lin, Cheng-Huan Peng   +8 more
doaj   +2 more sources

Comparative Analysis of TNF-alpha, TNF-R1, and TNF-R2 in Patients with Low-impact Fractures Due to Osteoporosis [PDF]

Revista Brasileira de Ortopedia, 2023
Objective To analyze the serum levels of TNF-alpha and its TNF-R1 and TNF-R2 receptors in the blood of patients with low-impact fractures due to osteoporosis, comparing between genders and with healthy patients. Methods The present study was conducted
Abel Oliveira Marques Teixeira, Virmondes Rodrigues-Júnior, Bárbara Rocha Rodrigues, Danila Malheiros Souza, Leonardo Franco Pinheiro Gaia, Denise Bertulucci Rocha Rodrigues   +5 more
doaj   +1 more source

Tumor Necrosis Factor Alpha Signaling and Organogenesis

Frontiers in Cell and Developmental Biology, 2021
Tumor necrosis factor alpha (TNF-α) plays important roles in processes such as immunomodulation, fever, inflammatory response, inhibition of tumor formation, and inhibition of viral replication.
Kai You, Hui Gu, Zhengwei Yuan, Xuewen Xu, Xuewen Xu   +4 more
doaj   +1 more source

Adverse events of tumor necrosis factor alpha inhibitors for the treatment of ankylosing spondylitis: A meta-analysis of randomized, placebo-controlled trials

Frontiers in Pharmacology, 2023
Objective: Tumor necrosis factor alpha inhibitors (TNFi) have shown substantial efficacy in alleviating and treating ankylosing spondylitis (AS). However, the heightened interest is accompanied by concerns over adverse events.
Haihuan Feng, Haihuan Feng, Ying Zhao, Weihong Kuang, Yanping Dai, Xiaobo Cen, Feng Qin, Feng Qin   +7 more
doaj   +1 more source

Phytochemicals as inhibitors of tumor necrosis factor alpha and neuroinflammatory responses in neurodegenerative diseases

Neural Regeneration Research, 2022
Inflammatory processes and proinflammatory cytokines have a key role in the cellular processes of neurodegenerative diseases and are linked to the pathogenesis of functional and mental health disorders.
Fatemeh Zahedipour, Seyede Atefe Hosseini, Neil C Henney, George E Barreto, Amirhossein Sahebkar   +4 more
doaj   +1 more source

Transmembrane tumor necrosis factor alpha attenuates pressure-overload cardiac hypertrophy via tumor necrosis factor receptor 2.

PLoS Biology, 2020
Tumor necrosis factor-alpha (TNF-α) plays an important pathogenic role in cardiac hypertrophy and heart failure (HF); however, anti-TNF is paradoxically negative in clinical trials and even worsens HF, indicating a possible protective role of TNF-α in HF.
Kun Miao, Ling Zhou, Hongping Ba, Chenxi Li, Haiyan Gu, Bingjiao Yin, Jing Wang, Xiang-Ping Yang, Zhuoya Li, Dao Wen Wang   +9 more
doaj   +1 more source

Tumor Necrosis Factor-Alpha and Age-Related Pathologies

Архивъ внутренней медицины, 2020
Modern concepts about the «inflammaging» and the role of subclinical inflammation in various age-associated pathology are described in the review. Particular attention is paid to the tumor necrosis factor-α, a key cytokine that plays an important role in
S. V. Topolyanskaya
doaj   +1 more source

Alopecia secondary to anti-tumor necrosis factor-alpha therapy [PDF]

Anais Brasileiros de Dermatologia, 2015
Biologic drugs represent a substantial progress in the treatment of chronic inflammatory immunologic diseases. However, its crescent use has revealed seldom reported or unknown adverse reactions, mainly associated with anti-tumor necrosis factor (anti ...
Lara Beatriz Prata Ribeiro, Juliana Carlos Gonçalves Rego, Bruna Duque Estrada, Paula Raso Bastos, Juan Manuel Piñeiro Maceira, Celso Tavares Sodré   +5 more
doaj   +1 more source

Development of low blood glucose readings in nine non-diabetic patients treated with tumor necrosis factor-alpha inhibitors: a case series

Journal of Medical Case Reports, 2012
Introduction Treatment with various biological agents in disease states such as rheumatoid arthritis has been associated with multiple side effects. Whereas many of these are frequently reported in the literature, hypoglycemia, a possible side effect of ...
Czajkowska Jadwiga B, Shutty Brandon, Zito Susan   +2 more
doaj   +1 more source

Evaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis [PDF]

International Journal of Fertility and Sterility, 2015
Background The pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), is a pathogenic element for a number of disorders. Previous studies have reported that the -1031 T/C and -238 G/A polymorphisms in the promoter region of the TNF-α gene are ...
Roshanak Abutorabi, Azar Baradaran, Fatemeh Sadat Mostafavi, Yasaman Zarrin, Farahnaz Mardanian   +4 more
doaj   +1 more source