Results 241 to 250 of about 1,355,842 (299)

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

British Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis   +3 more
wiley   +1 more source

Automated tumor-stroma ratio estimation for improved prognostic stratification of squamous cell carcinoma of the oral tongue. [PDF]

J Pathol Clin Res
Wang L, Sörensen K, Coates PJ, Gu X, Sgaramella N, Barre MM, Nylander K.   +6 more
europepmc   +1 more source

SERPINE1 Alternative Polyadenylation Influences Gastric Cancer Prognosis via N6‐Methyladenosine Modification

Cancer Science, EarlyView.
Multi‐omics integration of the transcriptomic APA landscape and m6A modifications identifies key prognostic genes. Their biological functions and molecular mechanisms in promoting tumor progression are comprehensively validated through in vitro assays. ABSTRACT Alternative polyadenylation (APA) and N6‐methyladenosine (m6A) methylation are critical post‐
Zhuoyi Wu, Ruyun Xu, Ju Fang, Bing Liu, Cao Zhang, Shangxin Zhang, Jing Ni   +6 more
wiley   +1 more source

Comparative Prognostic Roles of β-Catenin Expression and Tumor-Stroma Ratio in Pancreatic Cancer: Neoadjuvant Chemotherapy vs. Upfront Surgery. [PDF]

Curr Oncol
Oikawa S, Mitomi H, Murai S, Nakayama A, Chiba S, Nishihara S, Ishii Y, Yamochi T, Yoshida H.   +8 more
europepmc   +1 more source

LAMC2+ Epithelial Cells Drive Bladder Cancer Progression and Predict Immunotherapy Response via SERPINB3/STAT3/CD44 Axis

Cancer Science, EarlyView.
This study identified LAMC2+ epithelial cells through single‐cell sequencing and found that high expression of LAMC2 is associated with the malignant progression of bladder cancer. HdWGCNA and transcriptome sequencing revealed the SerpinB3/STAT3/CD44 axis. Diosmetin was selected as a potential LAMC2 inhibitor.
Yutong Chen, Yunzhong Jiang, Zezhong Yang, Minxuan Jing, Wentai Wu, Jiale He, Lu Wang, Minghai Ma, Yaodong Zhang, Min Wang, Jianpeng Li, Yuanchun Pu, Bingliang He, Yanjia Liu, Kaibo Mi, Hang Liu, Mengzhao Zhang, Jinhai Fan   +17 more
wiley   +1 more source

Taming the Tumor Stroma: A Two-Stage Targeted Nanocapsule for Potent Deep Chemo-Immunotherapy in Triple-Negative Breast Cancer. [PDF]

Pharmaceutics
Xing B, Shen X, Jia X, Zhang Y, Liu Z, Guo X, Li X, Liu Z.   +7 more
europepmc   +1 more source

Targeting Tumor Stroma in CMS4 Colorectal Cancer: Phospholamban Takes Center Stage. [PDF]

Cell Mol Gastroenterol Hepatol
Williams CS.
europepmc   +1 more source

Nomogram for predicting tumor-stroma ratio in pancreatic ductal adenocarcinoma using dual-energy computed tomography. [PDF]

BMC Med Imaging
Chen W, Lin G, Mao W, Cao J, Xia S, Xu M, Lu C, Chen M, Ji J.   +8 more
europepmc   +1 more source

A 3‐year‐old girl with a left optic nerve tumor

Brain Pathology, EarlyView.
Samuel López Muñoz, Alberto Berjón, Carlos Rodríguez Antolín, Claudia Sánchez Lara, Marta Mendiola, Victoria Heredia Soto, Álvaro Lassaletta, Carlos González Pérez, Pedro Rubio Aparicio, Jorge Zamorano, Isabel Esteban Rodríguez   +10 more
wiley   +1 more source

Added value of tumor-stroma ratio to postsurgery circulating tumor DNA and pTN stage in risk stratification of patients with stage III colon cancer treated with adjuvant chemotherapy. [PDF]

ESMO Open
Franken IA, Heilijgers F, Bakker ME, Rubio-Alarcón C, van der Baan FH, Lemmens M, Diemen PD, Sausen M, Meijer GA, Koopman M, Vink GR, Fijneman RJA, Mesker WE, Roodhart JML.   +13 more
europepmc   +1 more source