Results 11 to 20 of about 1,122,815 (355)

Application Route and Immune Status of the Host Determine Safety and Oncolytic Activity of Oncolytic Coxsackievirus B3 Variant PD-H

Viruses, 2021
The coxsackievirus B3 strain PD-0 has been proposed as a new oncolytic virus for the treatment of colorectal carcinoma. Here, we generated a cDNA clone of PD-0 and analyzed the virus PD-H, newly generated from this cDNA, in xenografted and syngenic ...
Ahmet Hazini, Babette Dieringer, Karin Klingel, Markian Pryshliak, Anja Geisler, Dennis Kobelt, Ole Daberkow, Jens Kurreck, Sophie van Linthout, Henry Fechner   +9 more
doaj   +1 more source

Virus infections in tumors pave the way for tumor-directed DC-vaccines [PDF]

OncoImmunology, 2012
Effective treatment of solid cancers by tumor-directed DC-vaccines still remains a challenge in clinical oncology. For therapeutic success, knock-down of tumor-specific tolerance appears mandatory before a potent tumor-specific cytotoxic T-cell response can be triggered by DC-vaccinations.
Woller, Norman, Kühnel, Florian, Kubicka, Stefan   +2 more
openaire   +2 more sources

The Role of DNA Viruses in Human Cancer

Cancer Informatics, 2023
This review discusses the possible involvement of infections-associated cancers in humans, with virus infections contributing 15% to 20% of total cancer cases in humans.
Mehdi Fazlalipour, Zohreh-al-sadat Ghoreshi, Hamid Reza Molaei, Nasir Arefinia   +3 more
doaj   +1 more source

Hepatitis C virus infection triggers a tumor‐like glutamine metabolism [PDF]

Hepatology, 2017
Chronic infection with hepatitis C virus (HCV) is one of the main causes of hepatocellular carcinoma. However, the molecular mechanisms linking the infection to cancer development remain poorly understood. Here we used HCV‐infected cells and liver biopsies to study how HCV modulates the glutaminolysis pathway, which is known to play an important role ...
Levy, P.L., Duponchel, S., Eischeid, H., Molle, Jennifer, Michelet, M., Diserens, G., Vermathen, M., Vermathen, P., Dufour, J.F., Dienes, H.P., Steffen, H.M., Odenthal, M., Zoulim, F., Bartosch, B.   +13 more
openaire   +4 more sources

Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus. [PDF]

PLoS Pathogens, 2011
Vaccine and laboratory adapted strains of measles virus can use CD46 as a receptor to infect many human cell lines. However, wild type isolates of measles virus cannot use CD46, and they infect activated lymphocytes, dendritic cells, and macrophages via ...
Ryan S Noyce, Daniel G Bondre, Michael N Ha, Liang-Tzung Lin, Gary Sisson, Ming-Sound Tsao, Christopher D Richardson   +6 more
doaj   +1 more source

Avaliação da eficácia do cidofovir na papilomatose respiratória recorrente juvenil Efficacy of cidofovir in recurrent juvenile respiratory papillomatosis

Brazilian Journal of Otorhinolaryngology, 2010
O uso do cidofovir para papilomatose respiratória recorrente juvenil (PRRJ) ainda não tem estudos caso-controle suficientes que comprovem sua eficácia em literatura. OBJETIVO: Avaliar fatores que influenciem o prognóstico da PRRJ, e observar a atuação do
Fabiana Valera, Lucas Maldonato, Jessé Lima, Daniel S Küpper, Rodrigo N Lacerda, Rui Mamede, Hilton Ricz   +6 more
doaj   +1 more source

DNA in Uninfected and Virus-Infected Cells Complementary to Avian Tumor Virus RNA [PDF]

Proceedings of the National Academy of Sciences, 1971
The 70S RNA component of several avian tumor viruses was hybridized with DNA extracted from avian tumor virus-infected and uninfected chicken and Japanese quail cells. Tritium-labeled 70S RNAs from Rous sarcoma virus (RSV), Rous associated virus-1 (RAV-1), RAV-60, and Schmidt-Ruppin-RSV (SR-RSV) hybridize from 3 to 10 times more with DNA ...
P N, Rosenthal, H L, Robinson, W S, Robinson, T, Hanafusa, H, Hanafusa   +4 more
openaire   +2 more sources

How Human Tumor Viruses Make Use of Autophagy

Cells, 2012
Viruses commandeer regulatory pathways of their hosts to optimize their success as cellular parasites. The human tumor viruses, Epstein-Barr Virus (EBV), Kaposi’s Sarcoma Herpesvirus (KSHV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) all affect
Bill Sugden, Zachary L. Pratt
doaj   +1 more source

PKR induces TGF-β and limits oncolytic immune therapy

Journal for ImmunoTherapy of Cancer, 2023
Background Mammalian cells have developed multiple intracellular mechanisms to defend against viral infections. These include RNA-activated protein kinase (PKR), cyclic GMP-AMP synthase and stimulation of interferon genes (cGAS-STING) and toll-like ...
Balveen Kaur, Guangsheng Pei, Zhongming Zhao, Jianhua Yu, Bangxing Hong, Upasana Sahu, Matthew P Mullarkey, Evan Hong, Yuanqing Yan, Yoshihiro Otani, Yeshavanth Banasavadi-Siddegowda, Huihui Fan, Michael A Caligiuri   +12 more
doaj   +1 more source

Modulation of antigen-specific T-cells as immune therapy for chronic infectious diseases and cancer [PDF]

, 2014
Copyright: © 2014 Li, Symonds, Miao, Sanderson and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Abraham, Ahmadzadeh, Akbar, Anderson, Baine, Barber, Baur, Belkaid, Bensinger, Bergmann, Berzofsky, Blackburn, Brooks, Brooks, Brooks, Colonna, Das, Day, Duraiswamy, Ejrnaes, Frebel, Geijtenbeek, Guidotti, Ha, Jerome, Jung, Kasprowicz, Kaufmann, Kim, Klein, Kroemer, Kroy, Larsson, Liu, Lu, Maizels, Malek, Matsuzaki, Mier, Mumprecht, Nandedkar, Nurieva, Nurieva, Ramsay, Schietinger, Schwartz, Sofra, Soldaini, Steinman, Trautmann, Vezys, Waggoner, Wedemeyer, Wilson, Yi, Zhou   +55 more
core   +2 more sources