Results 31 to 40 of about 1,122,815 (355)

Immune response to arbovirus infection in obesity

Frontiers in Immunology, 2022
Obesity is a global health problem that affects 650 million people worldwide and leads to diverse changes in host immunity. Individuals with obesity experience an increase in the size and the number of adipocytes, which function as an endocrine organ and
Muddassar Hameed, Elizabeth Geerling, Amelia K. Pinto, Iqra Miraj, James Weger-Lucarelli   +4 more
doaj   +1 more source

The role of viruses in the cancerogenesis

Journal of Medical Science, 2014
It is estimated that seven key viruses such as Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human T-lymphotropic virus (HTLV), Human papilloma viruses (HPV), Kaposi’s sarcoma-associated herpes-virus (KSHV), Epstein-Barr virus (EBV) and Merkel cell ...
Michał Chojnicki, Mariola Pawlaczyk, Celina Helak-Łapaj, Jakub Żurawski, Krzysztof Wiktorowicz   +4 more
doaj   +1 more source

Cytotoxic CD4+ T cells in chronic viral infections and cancer

Frontiers in Immunology, 2023
CD4+ T cells play an important role in immune responses against pathogens and cancer cells. Although their main task is to provide help to other effector immune cells, a growing number of infections and cancer entities have been described in which CD4+ T
Anna Malyshkina, Alicia Brüggemann, Annette Paschen, Ulf Dittmer   +3 more
doaj   +1 more source

Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]

, 2019
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence, Keenan, Bridget P, Kelley, Robin K   +2 more
core   +2 more sources

Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

Nature Communications, 2019
The immunosuppressive tumor microenvironment limits the success of current immunotherapies. The host retains memory T cells specific for previous infections throughout the entire body that are capable of executing potent and immediate immunostimulatory ...
Pamela C. Rosato, Sathi Wijeyesinghe, J. Stolley, Christine E. Nelson, Rachel L. Davis, Luke S. Manlove, C. Pennell, B. Blazar, Clark C. Chen, Melissa A. Geller, V. Vezys, D. Masopust   +11 more
semanticscholar   +1 more source

Human immunodeficiency virus p24 antigen and antibody, herpes simplex virus-2 IgM and tumor necrosis factor alpha plasma levels in adult female children living in single-parent households: a case-control observational study

Journal of Bio-X Research, 2022
. Objective:. Human immunodeficiency virus (HIV) p24 antigen and antibody and herpes simplex virus 2 IgM are seromarkers indicating infection with HIV and herpes simplex virus-2 (HSV-2), respectively, whereas tumor necrosis factor α is an inflammatory ...
Mathew Folaranmi Olaniyan, Tolulope Busayo Olaniyan   +1 more
doaj   +1 more source

Cutaneous smooth muscle tumors associated with Epstein-Barr virus in an adult patient with HIV, [PDF]

Anais Brasileiros de Dermatologia, 2021
Epstein Barr virus-associated smooth muscle tumors are an uncommon neoplasm that occurs in immunosuppressed patients of any age. Usually, it presents as multifocal tumors mainly in the spinal cord, epidural region, gastrointestinal tract and liver, upper
Estefania Galeano-Piedrahita, Ana Maria Maya Rico, Ana Cristina Ruiz Suárez, Andrea Laverde Walter   +3 more
doaj   +1 more source

Fighting viral infections and virus-driven tumors with cytotoxic CD4+ T cells [PDF]

, 2017
CD4+ T cells have been and are still largely regarded as the orchestrators of immune responses, being able to differentiate into distinct T helper cell populations based on differentiation signals, transcription factor expression, cytokine secretion, and
Adhikary, Adhikary, Adhikary, Ahn, Anderson, Annunziato, Appay, Appay, Aslan, Balfour, Battaglia, Baumjohann, Bickham, Bosselut, Britt, Brown, Brown, Brown, Brown, Brown, Bui, Cao, Cao, Cao, Carpenter, Casazza, Chen, Cheroutre, Chiu, Coler, de Souza, Deligeoroglou, Demachi-Okamura, Depil, Devarajan, Di Mitri, Dillon, Draenert, Duftner, Dumitriu, Endo, Enssle, Eshima, Facchinetti, Farrar, Faè, Fishman, Fleischer, Fontenot, Freeman, Fu, Fu, Gamadia, Gao, Garcia-Chagollan, Gasser, Geginat, Gelband, Goonetilleke, Grabowska, Grakoui, Grant, Grant, Groh, Ha, Haigh, Haque, Heaton, Hegde, Heller, Heusinkveld, Hildemann, Hislop, Hohler, Homma, Houser, Hua, Huz, Icheva, James, Jameson, Jeitziner, Johnson, Jones, Jones, Jonjic, Kadish, Kannanganat, Kaufmann, Kayagaki, Kenter, Kenter, Khanolkar, King, King, Kobayashi, Koel, Krensky, Kroesen, Kruger, Kuroda, Lazdina, Li, Libri, Lin, Loewendorf, Long, Long, Long, Long, Luckheeram, Lunemann, MacArthur, Mackay, Magnani, Malnati, Man, Manzke, Marshall, Martorelli, Mattapallil, McKinstry, McMichael, Merlo, Merlo, Metkar, Miamen, Moormann, Morales, Mosmann, Mucida, Munz, Munz, Murphy, Musey, Namekawa, Nemes, Nikiforow, Nixon, Norris, Oestreich, Omiya, O’Shea, Pachnio, Pachnio, Paludan, Pender, Peng, Penna, Piriou, Plata, Porakishvili, Qui, Quigley, Ratto-Kim, Reis, Rentenaar, Rerks-Ngarm, Ressing, Rosenberg, Sacha, Sakaguchi, Sallusto, Sandbulte, Savic, Scherrenburg, Schueller, Schulze zur Wiesch, Schulze Zur Wiesch, Schwartz, Seresini, Seresini, Soghoian, Soghoian, Spaete, Stacey, Steele, Streeck, Stuller, Su, Sun, Tagawa, Takeuchi, Tenzer, Terahara, Tewari, Thursz, Todryk, Tong, Toussirot, Trautmann, Trautmann, Trifari, Tscharke, Turnbull, Ulsenheimer, Vacchio, van de Berg, van den Hende, van Leeuwen, Vasin, Veldhoen, Ventura, Verma, Veronese, Voo, Voo, Vossen, Walker, Walton, Wang, Wang, Welters, Welters, WHO, Wilkinson, Wilson, Wilson, Wintermeyer, Workman, Xie, Xue, Yan, Yewdell, Zaunders, Zaunders, Zheng, Zhou, Zuo, zur Hausen   +229 more
core   +2 more sources

The Hippo Pathway and Viral Infections

Frontiers in Microbiology, 2020
The Hippo signaling pathway is a novel tumor suppressor pathway, initially found in Drosophila. Recent studies have discovered that the Hippo signaling pathway plays a critical role in a wide range of biological processes, including organ size control ...
Zhilong Wang, Wanhang Lu, Yiling Zhang, Feng Zou, Zhigang Jin, T. Zhao   +5 more
semanticscholar   +1 more source

Apoptotic epitope-specific CD8+ T cells and interferon signaling intersect in chronic hepatitis C virus infection [PDF]

, 2015
CD8(+) T cells specific to caspase-cleaved antigens derived from apoptotic T cells represent a principal player in chronic immune activation (CIA). Here, we found that both apoptotic epitope (AE)-specific and hepatitis C virus (HCV)-specific CD8(+) T ...
Accapezzato, Daniele, Barnaba, Vincenzo, Calvo, Ludovica, Cavallari, EUGENIO NELSON, Citro, Alessandra, Coccia, Eliana M, D'Ettorre, Gabriella, DE MARZIO, Paolo, DI FILIPPO, Simona, Grazi, Gian Luca, Labbadia, Giancarlo, Martini, Helene, Martire, Carmela, Piconese, Silvia, Rizzo, Fabiana, Sette, Alessandro, Severa, Martina, Sidney, John, Vullo, Vincenzo   +18 more
core   +1 more source