Results 61 to 70 of about 1,122,815 (355)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The Differentiation and Protective Function of Cytolytic CD4 T Cells in Influenza Infection

Frontiers in Immunology, 2016
CD4 T cells that recognize peptide antigen in the context of Class II MHC can differentiate into various subsets that are characterized by their helper functions.
Deborah M. Brown, Anna T. Lampe, Aspen M. Workman   +2 more
doaj   +1 more source

Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1 [PDF]

, 2014
Immune evasion strategies are important for the onset and the maintenance of viral infections. Many viruses have evolved mechanisms to counteract or suppress the host immune response.
Adler, Ankel, Artuso, Canalejo Castrillero, Carlos A. Pujol, Carlucci, Chew, Chiang, Ellermann-Eriksen, Finton, Florencia N. Linero, Glorieux, Hull, Karasneh, Lucey, Luis A. Scolaro, M. Carolina Artuso, M. Josefina Carlucci, Martinez, Mateu, Mogensen, Murphy, Nandakumar, Opal, Paludan, Reading, Romagnani, Rosa Wainstok, Silvina Gazzaniga, Smyth, Stumpf, Teng   +31 more
core   +2 more sources

Molecular Concepts of Virus Infections Causing Skin Cancer in Organ Transplant Recipients

American Journal of Transplantation, 2008
Globally approximately 15% of all malignant tumors are caused by viruses and even a higher percentage is observed in organ transplant recipients (OTR). Here, nonmelanoma skin cancer (NMSC) is the most frequent malignancy, which correlates with cutaneous ...
I. Nindl, F. Rösl
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

High‐Frequency Mutations in TP53, AXIN1, CTNNB1, and KRAS, and Polymorphisms in JAK1 Genes Among Mongolian HCC Patients

Cancer Reports
Background Mongolia has the highest incidence of liver cancer worldwide, largely driven by a high prevalence of hepatitis virus infections. Mutations in oncogenes and tumor suppressor genes provide valuable insights into the molecular mechanisms of ...
Nomin Bold, Khurelsukh Buyanbat, Ariya Enkhtuya, Nomin Myagmar, Gerelsuren Batbayar, Zolzaya Sandag, Dolgion Damdinbazar, Nomuun Oyunbat, Tuul Boldbaatar, Ankhbayar Enkhbaatar, Gan‐Erdene Baatarjav, Taivan Nanzaddorj, Tsendsuren Oyunsuren, Gantulga Davaakhuu   +13 more
doaj   +1 more source

C-Terminal Binding Protein: Regulator between Viral Infection and Tumorigenesis

Viruses
C-terminal binding protein (CtBP), a transcriptional co-repressor, significantly influences cellular signaling, impacting various biological processes including cell proliferation, differentiation, apoptosis, and immune responses.
Meihui Huang, Yucong Li, Yuxiao Li, Shuiping Liu   +3 more
doaj   +1 more source

The landscape of viral associations in human cancers [PDF]

, 2020
Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential ...
Alawi, Malik, Borozan, Ivan, Brewer, Daniel S, Cooper, Colin S, Desai, Nikita, Eils, Roland, Ferretti, Vincent, Grundhoff, Adam, Iskar, Murat, Lichter, Peter, Moch, Holger, PCAWG Consortium, PCAWG Pathogens, Sültmann, Holger, Zapatka, Marc   +14 more
core   +3 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors. [PDF]

PLoS Pathogens, 2010
NK and gammadelta T cells can eliminate tumor cells in many experimental models, but their effect on the development of tumors caused by virus infections in vivo is not known.
Rabinarayan Mishra, Alex T Chen, Raymond M Welsh, Eva Szomolanyi-Tsuda   +3 more
doaj   +1 more source