Results 21 to 30 of about 583 (139)

Dry Amorphization of Itraconazole Using Mesoporous Silica and Twin-Screw Technology [PDF]

Pharmaceutics
Background/Objectives: Amorphization of an active pharmaceutical ingredient (API) can improve its dissolution and enhance bioavailability. Avoiding solvents for drug amorphization is beneficial due to environmental issues and potential solvent residues ...
Margarethe Richter, Simon Welzmiller, Fred Monsuur, Annika R. Völp, Joachim Quadflieg   +4 more
doaj   +2 more sources

Evaluation of Polyvinyl Alcohol as Binder during Continuous Twin Screw Wet Granulation [PDF]

Pharmaceutics
Binder selection is a crucial step in continuous twin-screw wet granulation (TSWG), as the material experiences a much shorter residence time (2–40 s) in the granulator barrel compared to batch-wise granulation processes. Polyvinyl alcohol (PVA) 4-88 was
Phaedra Denduyver, Gudrun Birk, Alessandra Ambruosi, Chris Vervaet, Valérie Vanhoorne   +4 more
doaj   +2 more sources

3D Population Balance Model for Continuous Twin Screw Granulator

Chemical Engineering Transactions, 2013
Continuous processes could be applied to improve cost-efficiency of pharmaceutical manufacturing that has traditionally relied on batch processing due to regulatory requirements and small lot sizes.
M. Paavola, A. El Hagrasy, J. Litster, K. Leiviska   +3 more
doaj   +2 more sources

Twin Screw Melt Granulation of Simvastatin: Drug Solubility and Dissolution Rate Enhancement Using Polymer Blends [PDF]

Pharmaceutics
Background/Objectives: This study evaluates the efficacy of twin screw melt granulation (TSMG), and hot-melt extrusion (HME) techniques in enhancing the solubility and dissolution of simvastatin (SIM), a poorly water-soluble drug with low bioavailability.
Rasha M. Elkanayati, Indrajeet Karnik, Prateek Uttreja, Nagarjuna Narala, Sateesh Kumar Vemula, Krizia Karry, Michael A. Repka   +6 more
doaj   +2 more sources

Optimizing Energy Efficiency of a Twin-Screw Granulation Process in Real-Time Using a Long Short-Term Memory (LSTM) Network [PDF]

ACS Engineering Au, 2023
Chaitanya Sampat, Rohit Ramachandran
doaj   +2 more sources

Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process

Pharmaceutics, 2021
The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet granulation should rely
Lise Vandevivere, Maxine Vangampelaere, Christoph Portier, Cedrine de Backere, Olaf Häusler, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne   +7 more
doaj   +1 more source

Parametric Study of Residence Time Distributions and Granulation Kinetics as a Basis for Process Modeling of Twin-Screw Wet Granulation

Pharmaceutics, 2021
Twin-screw wet granulation is a crucial unit operation in shifting from pharmaceutical batch to continuous processes, but granulation kinetics as well as residence times are yet poorly understood.
Timo Plath, Carolin Korte, Rakulan Sivanesapillai, Thomas Weinhart   +3 more
doaj   +1 more source

Asymmetric distribution in twin screw granulation [PDF]

European Journal of Pharmaceutics and Biopharmaceutics, 2016
Positron Emission Particle Tracking (PEPT) was successfully employed to validate measured transverse asymmetry in material distribution in the conveying zones of a Twin Screw Granulator (TSG). Flow asymmetry was established to be a property of the granulator geometry and dependent on fill level. The liquid distribution of granules as a function of fill
Tim, Chan Seem, Neil A, Rowson, Ian, Gabbott, Marcel, de Matas, Gavin K, Reynolds, Andy, Ingram   +5 more
openaire   +2 more sources

Particle-Scale Modeling to Understand Liquid Distribution in Twin-Screw Wet Granulation

Pharmaceutics, 2021
Experimental characterization of solid-liquid mixing for a high shear wet granulation process in a twin-screw granulator (TSG) is very challenging. This is due to the opacity of the multiphase system and high-speed processing.
Ashish Kumar, Stefan Radl, Krist V. Gernaey, Thomas De Beer, Ingmar Nopens   +4 more
doaj   +1 more source

Influence of the Feedstock Preparation on the Properties of Highly Filled Alumina Green-Body and Sintered Parts Produced by Fused Deposition of Ceramic

Ceramics, 2023
This paper investigates new approaches for the blending and plastification of ceramic powder with a binder to form fused deposition of ceramic (FDC) feedstock.
Thomas Heim, Frank Kern
doaj   +1 more source