Results 31 to 40 of about 583 (139)
British Journal of Pharmacy, 2022 The pharmaceutical industry has a growing interest in continuous manufacturing, particularly for high-volume dosage forms such as solid oral tablets. This is driven by the obvious benefits such as small footprint, batch size flexibility, the relative ...
Valentyn Mohylyuk +4 more
doaj +1 more source
Macromol, 2021 High-molecular-weight hypromellose (HPMC) and hydroxypropyl cellulose (HPC) are widely known, extended-release polymers. Conventional high-molecular-weight HPMCs are preferred in extended-release applications but not widely used in twin-screw melt ...
Amol Batra +9 more
doaj +1 more source
Twin screw granulation — A literature review [PDF]
Powder Technology, 2015 Abstract This review article addresses the currently available literature on twin screw granulation (TSG). TSG is an emerging technology rapidly gaining interest in the pharmaceutical industry as a method of continuous wet granulation. The control of the geometry of the granulator over the formation of granules and the mechanisms of granulation are ...
Tim Chan Seem +7 more
openaire +1 more source
Continuous Melt Granulation for Taste-Masking of Ibuprofen
Pharmaceutics, 2021 Taste-masking of drugs, particularly to produce formulations for pediatric patients, can be challenging and require complex manufacturing approaches. The objective of this study was to produce taste-masked ibuprofen granules using a novel process, twin ...
Seth P. Forster, David B. Lebo
doaj +1 more source
Twin-screw granulation – a systematic analysis of process parameters
British Journal of Pharmacy, 2018 Twin-screw granulation has a significant advantage over traditional granulation methods leading to the possibility of continuous manufacturing. Although this technology has drawn attention in recent years, the general understanding of the process is ...
Margarethe Richter
doaj +1 more source
Pharmaceutics, 2021 Recently, the pharmaceutical industry has undergone changes in the production of solid oral dosages from traditional inefficient and expensive batch production to continuous manufacturing.
Ana Alejandra Barrera Jiménez +4 more
doaj +1 more source
Quantitative Assessment of Mass Flow Boundaries in Continuous Twin-screw Granulation
CHIMIA, 2016 In pharmaceutical manufacturing, there is an increasing interest in continuous manufacturing. As an example for fast continuous processes in general of considerable complexity, this study was focussed on improving the understanding of twin-screw
Adrian Schmidt +4 more
doaj +1 more source
Pharmaceutics, 2022 Twin screw granulation (TSG) is a continuous wet granulation technique that is used widely across different solid manufacturing industries. The TSG has been recognized to have numerous advantages due to its modular design and continuous manufacturing ...
Lalith Kotamarthy +2 more
doaj +1 more source
Conceptualisation of an Efficient Particle-Based Simulation of a Twin-Screw Granulator
Pharmaceutics, 2021 Discrete Element Method (DEM) simulations have the potential to provide particle-scale understanding of twin-screw granulators. This is difficult to obtain experimentally because of the closed, tightly confined geometry.
John P. Morrissey +2 more
doaj +1 more source
Scaling of continuous twin screw wet granulation [PDF]
AIChE Journal, 2016 Scaling rules were developed and tested for a continuous twin screw wet granulation process using three scales (11, 16, and 24 mm barrel diameter) of twin screw granulators (TSG). The distributive feed screw configuration used produced high porosity granules (50–60%) with broad bimodal size distributions, especially in the 16 and 24 mm TSGs.
Osorio, J.G. +6 more
openaire +5 more sources