Advances in Twin-Screw Granulation [PDF]
Pharmaceutics, 2021 Twin-screw granulation (TSG) is an emerging process technology that allows both wet and dry granulation of powders with a wide range of properties [...]
Valérie Vanhoorne, Ashish Kumar
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Advances in Twin-Screw Granulation Processing [PDF]
Pharmaceutics, 2021 Twin-screw granulation (TSG) is a pharmaceutical process that has gained increased interest from the pharmaceutical industry for its potential for the development of oral dosage forms.
Uttom Nandi +3 more
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Process Simulation of Twin-Screw Granulation: A Review [PDF]
PharmaceuticsTwin-screw granulation has emerged as a key process in powder processing industries and in the pharmaceutical sector to produce granules with controlled properties.
Tony Bediako Arthur, Nejat Rahmanian
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Twin Screw Granulation: Effects of Properties of Primary Powders [PDF]
Pharmaceutics, 2018 Lactose and mannitol are some of the most commonly used powders in the pharmaceutical industry. The limited research published so far highlights the effects of process and formulation parameters on the properties of the granules and the tablets produced ...
Sushma V. Lute +2 more
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Continuous Twin Screw Granulation: A Review of Recent Progress and Opportunities in Formulation and Equipment Design [PDF]
Pharmaceutics, 2021 Continuous twin screw wet granulation is one of the key continuous manufacturing technologies that have gained significant interest in the pharmaceutical industry as well as in academia over the last ten years.
Christoph Portier +2 more
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A Semi-Mechanistic Prediction of Residence Time Metrics in Twin Screw Granulation [PDF]
Pharmaceutics, 2021 This work is concerned with the semi-mechanistic prediction of residence time metrics using historical data from mono-component twin screw wet granulation processes.
Shashank Venkat Muddu +2 more
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Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability during granulation and drying – A QbD approach [PDF]
International Journal of Pharmaceutics: X, 2021 Despite significant advances in the research domain of continuous twin screw granulation, limited information is currently available on the impact of raw material properties, especially considering batch-to-batch variability.
Christoph Portier +7 more
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Twin Screw Granulation: An Investigation of the Effect of Barrel Fill Level [PDF]
Pharmaceutics, 2018 This paper focuses on investigating the influence of varying barrel fill levels on the mean residence time, granule properties (median size, size distribution, and shape), and tensile strength of tablets.
Sushma V. Lute +2 more
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Integrated Continuous Wet Granulation and Drying: Process Evaluation and Comparison with Batch Processing [PDF]
Pharmaceutics, 2023 The pharmaceutical industry is in the midst of a transition from traditional batch processes to continuous manufacturing. However, the challenges in making this transition vary depending on the selected manufacturing process.
Seth P. Forster +4 more
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Investigating the Effects of Mixing Dynamics on Twin-Screw Granule Quality Attributes via the Development of a Physics-Based Process Map [PDF]
PharmaceuticsTwin-screw granulation (TSG) is an emerging continuous wet granulation technique that has not been widely applied in the industry due to a poor mechanistic understanding of the process.
Lalith Kotamarthy +4 more
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