Results 91 to 100 of about 28,841 (200)

miR186 suppresses prostate cancer progression by targeting Twist1

Oncotarget, 2016
Prostate cancer (PCa) is the second leading cause of cancer-related deaths in north American men, and most its related deaths are due to advanced and metastatic PCa. However, the molecular mechanisms underlying PCa progression are still unclear. Here we use a pair of prostate cell lines P69/M12, which have the same genetic background and the highly ...
Zhao, Xian, Wang, Yanli, Deng, Rong, Zhang, Hailong, Dou, Jinzhuo, Yuan, Haihua, Hou, Guofang, Du, Yuzhang, Chen, Qin, Yu, Jianxiu   +9 more
openaire   +3 more sources

Destabilization of the TWIST1/E12 complex dimerization following the R154P point-mutation of TWIST1: an in silico approach [PDF]

BMC Structural Biology, 2017
The bHLH transcription factor TWIST1 plays a key role in the embryonic development and in tumorigenesis. Some loss-of-function mutations of the TWIST1 gene have been shown to cause an autosomal dominant craniosynostosis, known as the Saethre-Chotzen syndrome (SCS).
Bouard, Charlotte, Terreux, Raphael, Tissier, Agnès, Jacqueroud, Laurent, Vigneron, Arnaud, Ansieau, Stéphane, Puisieux, Alain, Payen, Léa   +7 more
openaire   +2 more sources

Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell–cell junctions during neural tube formation

Developmental Dynamics, EarlyView.
Abstract Background Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout
Derrick Thomas, Brittany M. Hufft‐Martinez, Zarna Lalwani, Vi Pham, Mary Elmeniawi, An J. Tran, Jianming Xu, Irfan Saadi, Walid D. Fakhouri   +8 more
wiley   +1 more source

Transition from normal to cancerous cell by precancerous niche (PCN) induced chronic cell-matrix stress

4 open, 2019
The attempt to restore homeostasis, once disrupted, such that complex signaling, crosstalk between ubiquitous proteins, and a diverse range of pathways gone awry is near impossible, especially in the presence of an ongoing pathogenic stimuli with ...
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

The FZD7‐TWIST1 axis is responsible for anoikis resistance and tumorigenesis in ovarian carcinoma

Molecular Oncology, 2019
Frizzled family receptor 7 (FZD7), a Wnt signaling receptor, is associated with the maintenance of stem cell properties and cancer progression. FZD7 has emerged as a potential therapeutic target because it is capable of transducing both canonical and ...
Ming Tan, Mohammad Asad, Valerie Heong, Meng Kang Wong, Tuan Zea Tan, Jieru Ye, Kuee Theng Kuay, Jean Paul Thiery, Clare Scott, Ruby Yun‐Ju Huang   +9 more
doaj   +1 more source

TWIST1 a new determinant of epithelial to mesenchymal transition in EGFR mutated lung adenocarcinoma. [PDF]

PLoS ONE, 2012
Metastasis is a multistep process and the main cause of mortality in lung cancer patients. We previously showed that EGFR mutations were associated with a copy number gain at a locus encompassing the TWIST1 gene on chromosome 7.
Karine Pallier, Anatole Cessot, Jean-Francois Côté, Pierre-Alexandre Just, Aurélie Cazes, Elizabeth Fabre, Claire Danel, Marc Riquet, Mojgan Devouassoux-Shisheboran, Stéphane Ansieau, Alain Puisieux, Pierre Laurent-Puig, Hélène Blons   +12 more
doaj   +1 more source

DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition i [PDF]

, 2017
The Nucleosome Remodeling and Deacetylase (NURD) complex is a key regulator of cell differentiation that has also been implicated in tumorigenesis. Loss of the NURD subunit Deleted in Oral Cancer 1 (DOC1) is associated with human oral squamous cell ...
Baatenburg de Jong, R.J. (Robert Jan), Bezstarosti, K. (Karel), Bot, A.G. (Alice), Demmers, J.A.A. (Jeroen), Fodde, R. (Riccardo), Herdt, M.J. (Maria) de, IJcken, W.F.J. (Wilfred) van, Looijenga, L.H.J. (Leendert), Mohd-Sarip, A. (Adone), Oole, E. (Edwin), Riet, J. (Job) van, Teeuwssen, M. (Miriam), Verrijzer, C.P. (Peter), Werken, H.J.G. (Harmen) van de, Willems, S.M. (Stefan Martin), Zatreanu, D. (Diana)   +15 more
core   +1 more source

Twist1 in Human White Adipose Tissue and Obesity [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2011
Twist1 is a transcription factor implicated in the regulation of TNFα signaling and was recently shown to be highly expressed in both human and murine adipose tissue, but its role in obesity is unknown.Our objective was to assess the expression of twist1 in human white adipose tissue (WAT), its relationship to obesity and insulin sensitivity, and how ...
Amanda T, Pettersson, Niklas, Mejhert, Margareta, Jernås, Lena M S, Carlsson, Ingrid, Dahlman, Jurga, Laurencikiene, Peter, Arner, Mikael, Rydén   +7 more
openaire   +2 more sources

PVT1 lincRNA signals an androgen‐dependent transcriptional activation program of oncogenes in prostate cancer cells

International Journal of Cancer, EarlyView.
What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho, Fabio Nunes de Mello, Ana Carolina Tahira, Gabriel Nakanishi Fortes, Agatha Fischer‐Carvalho, Pedro Jardim Poli, Murilo Sena Amaral, Sergio Verjovski‐Almeida   +7 more
wiley   +1 more source