Results 11 to 20 of about 2,770,969 (263)
Clinical Chemistry, 1999 AbstractType 1 (insulin-dependent) diabetes occurs worldwide and can appear at any age. The genetic susceptibility is strongly associated with HLA-DQ and DR on chromosome 6, but genetic factors on other chromosomes such as the insulin gene on chromosome 11 and the cytotoxic T-lymphocyte antigen gene on chromosome 2 may modulate disease risk.
Åke Lernmark, Shehab Alshiekh
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Advances in Human Immune System Mouse Models for Personalized Treg-Based Immunotherapies
Frontiers in Immunology, 2021 Immunodeficient mice engrafted with a functional human immune system [Human immune system (HIS) mice] have paved the way to major advances for personalized medicine and translation of immune-based therapies.
Isabelle Serr +8 more
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The Lancet, 2014 Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease prediction and heterogeneity, pancreatic pathology, and epidemiology. Technological improvements in insulin pumps and continuous glucose monitors help patients with type 1 diabetes manage the challenge ...
George S. Eisenbarth +2 more
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BMJ Open, 2023 Objectives Cardiovascular disease (CVD) is a precarious complication of type 1 diabetes (T1D). Alongside glycaemic control, lipid and blood pressure (BP) management are essential for the prevention of CVD.
Bruce H R Wolffenbuttel +4 more
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Adolescent type 1 Diabetes Cardio-renal Intervention Trial (AdDIT). [PDF]
, 2011 BACKGROUND: The prognosis for young people diagnosed with diabetes during childhood remains poor and this is mainly related to the long-term risk of developing vascular complications.Microalbuminuria identifies subjects at risk for diabetic nephropathy ...
Adolescent type 1 Diabetes cardio-renal Intervention Trial Research Group
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Frontiers in Immunology, 2021 Type 1 diabetes is an immune-driven disease, where the insulin-producing beta cells from the pancreatic islets of Langerhans becomes target of immune-mediated destruction.
Caroline Frørup +22 more
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Residual C-peptide secretion and hypoglycemia awareness in people with type 1 diabetes
BMJ Open Diabetes Research & Care, 2021 Introduction This study aimed to assess the association between fasting serum C-peptide levels and the presence of impaired awareness of hypoglycemia (IAH) in people with type 1 diabetes.Research design and methods We performed a cross-sectional study ...
Giesje Nefs +9 more
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Subclinical type 1 diabetes [PDF]
JRSM, 2002 Type 1 diabetes typically presents with acute osmotic symptoms or diabetic decompensation. It is seldom diagnosed solely as the result of a blood test.
Shawarna S Lasker, Tahseen A Chowdhury
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Antigen-Specific Treg Therapy in Type 1 Diabetes – Challenges and Opportunities
Frontiers in Immunology, 2021 Regulatory T cells (Tregs) are key mediators of peripheral self-tolerance and alterations in their frequencies, stability, and function have been linked to autoimmunity.
Isabelle Serr +7 more
doaj +1 more source
Glucose and C-Peptide Changes in the Perionset Period of Type 1 Diabetes in the Diabetes Prevention Trial–Type 1 [PDF]
, 2008 OBJECTIVE—We examined metabolic changes in the period immediately after the diagnosis of type 1 diabetes and in the period leading up to its diagnosis in Diabetes Prevention Trial–Type 1 (DPT-1 ...
D. Cuthbertson +20 more
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