Results 11 to 20 of about 4,565,322 (357)
Screening for Type 1 Diabetes in the General Population: A Status Report and Perspective.
Diabetes, 2022 Most screening programs to identify individuals at risk for type 1 diabetes have targeted relatives of people living with the disease to improve yield and feasibility.
E. Sims +17 more
semanticscholar +1 more source
Clinical Chemistry, 1999 AbstractType 1 (insulin-dependent) diabetes occurs worldwide and can appear at any age. The genetic susceptibility is strongly associated with HLA-DQ and DR on chromosome 6, but genetic factors on other chromosomes such as the insulin gene on chromosome 11 and the cytotoxic T-lymphocyte antigen gene on chromosome 2 may modulate disease risk.
Åke Lernmark, Shehab Alshiekh
openaire +4 more sources
The Lancet, 2014 Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease prediction and heterogeneity, pancreatic pathology, and epidemiology. Technological improvements in insulin pumps and continuous glucose monitors help patients with type 1 diabetes manage the challenge ...
George S. Eisenbarth +2 more
openaire +3 more sources
Advances in Human Immune System Mouse Models for Personalized Treg-Based Immunotherapies
Frontiers in Immunology, 2021 Immunodeficient mice engrafted with a functional human immune system [Human immune system (HIS) mice] have paved the way to major advances for personalized medicine and translation of immune-based therapies.
Isabelle Serr +8 more
doaj +1 more source
Prevalence and incidence of type 1 diabetes in the world: a systematic review and meta-analysis
Health Promotion Perspectives, 2020 Background: Diabetes is referred to a group of diseases characterized by high glucose levels in blood. It is caused by a deficiency in the production or function of insulin or both, which can occur because of different reasons, resulting in protein and ...
M. Mobasseri +5 more
semanticscholar +1 more source
BMJ Open, 2023 Objectives Cardiovascular disease (CVD) is a precarious complication of type 1 diabetes (T1D). Alongside glycaemic control, lipid and blood pressure (BP) management are essential for the prevention of CVD.
Bruce H R Wolffenbuttel +4 more
doaj +1 more source
Trends in Prevalence of Type 1 and Type 2 Diabetes in Children and Adolescents in the US, 2001-2017.
Journal of the American Medical Association (JAMA), 2021 Importance Changes in the prevalence of youth-onset diabetes have previously been observed. Objective To estimate changes in prevalence of type 1 and type 2 diabetes in youths in the US from 2001 to 2017.
J. Lawrence +12 more
semanticscholar +1 more source
JAMA, 2003 Diabetes is a complex metabolic disorder diagnosed on the basis of hyperglycemia. Diagnostic criteria for the disorder are periodically revised (1). Diabetes may be classified mainly into types 1 and 2 based on the etiology and severity of insulin deficiency (1).
Yogish C. Kudva +2 more
openaire +8 more sources
Adult-Onset Type 1 Diabetes: Current Understanding and Challenges
Diabetes Care, 2021 Recent epidemiological data have shown that more than half of all new cases of type 1 diabetes occur in adults. Key genetic, immune, and metabolic differences exist between adult- and childhood-onset type 1 diabetes, many of which are not well understood.
L. Phillips +14 more
semanticscholar +1 more source
Molecular Metabolism, 2022 Background: The highly complex pathogenesis of Type 1 Diabetes is driven by several immune cell types with both effector and regulatory characteristics, which ultimately ends in the destruction of the insulin-producing beta cells.
Martin G. Scherm +5 more
doaj +1 more source