Results 11 to 20 of about 4,423,584 (309)
PDE12 in type 1 diabetes [PDF]
Scientific Reports, 2022 AbstractType 1 diabetes (T1D) incidence is increased after COVID-19 infection in children under 18 years of age. Interferon-α-activated oligoadenylate synthetase and downstream RNAseL activation degrade pathogen RNA, but can also damage host RNA when RNAseL activity is poorly regulated.
Tekin, Hasim +6 more
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Inflammasomes and Type 1 Diabetes [PDF]
Frontiers in Immunology, 2021 Microbiota have been identified as an important modulator of susceptibility in the development of Type 1 diabetes in both animal models and humans. Collectively these studies highlight the association of the microbiota composition with genetic risk, islet autoantibody development and modulation of the immune responses.
F. Susan Wong, James A. Pearson, Li Wen
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The Lancet, 2018 Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and disease burden ...
DiMeglio, Linda A. +2 more
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Clinical Chemistry, 1999 AbstractType 1 (insulin-dependent) diabetes occurs worldwide and can appear at any age. The genetic susceptibility is strongly associated with HLA-DQ and DR on chromosome 6, but genetic factors on other chromosomes such as the insulin gene on chromosome 11 and the cytotoxic T-lymphocyte antigen gene on chromosome 2 may modulate disease risk.
Åke Lernmark, Shehab Alshiekh
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The Lancet, 2014 Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease prediction and heterogeneity, pancreatic pathology, and epidemiology. Technological improvements in insulin pumps and continuous glucose monitors help patients with type 1 diabetes manage the challenge ...
George S. Eisenbarth +2 more
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JAMA, 2003 Diabetes is a complex metabolic disorder diagnosed on the basis of hyperglycemia. Diagnostic criteria for the disorder are periodically revised (1). Diabetes may be classified mainly into types 1 and 2 based on the etiology and severity of insulin deficiency (1).
Yogish C. Kudva +2 more
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Microbiome and type 1 diabetes [PDF]
eBioMedicine, 2019 The steep increase in the incidence of type 1 diabetes (T1D), in the Western world after World War II, cannot be explained solely by genetic factors but implies that this rise must be due to crucial interactions between predisposing genes and environmental changes.
Heli Siljander +2 more
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Ketoacidosis in type 2 diabetes- is it type 1 and ½ diabetes? [PDF]
BMJ Case Reports, 2011 A 64-year-old female with a background of type 2 diabetes became acutely unwell after being transferred from insulin to liraglutide, which is one of the new glucagon like peptide 1 analogues. On assessment in accident and emergency, she was diagnosed with diabetic ketoacidosis and pancreatits. Glutamic acid decarboxylase antibodies were positive at 45 (
Sathis Kumar +2 more
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Prevention of Type 1 Diabetes [PDF]
Pediatric Clinics of North America, 2009 Prevention of loss of beta cells in type 1 diabetes is a major goal of current research. Knowledge of the genetic susceptibility, increasing ability to predict who may be at risk, recognition of the potential clinical impact of residual insulin secretion after diagnosis, and development of new immunomodulatory agents have supported an increasing number
Denis Daneman, Diane K. Wherrett
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A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes.
New England Journal of Medicine, 2020 BACKGROUND A closed-loop system of insulin delivery (also called an artificial pancreas) may improve glycemic outcomes in children with type 1 diabetes. METHODS In a 16-week, multicenter, randomized, open-label, parallel-group trial, we assigned, in a ...
M. Breton +3 more
semanticscholar +1 more source