Antigen-Specific Treg Therapy in Type 1 Diabetes – Challenges and Opportunities
Frontiers in Immunology, 2021 Regulatory T cells (Tregs) are key mediators of peripheral self-tolerance and alterations in their frequencies, stability, and function have been linked to autoimmunity.
Isabelle Serr +7 more
doaj +1 more source
A journey toward an open data culture through transformation of shared data into a data resource
Data & Policy, 2022 The transition to open data practices is straightforward albeit surprisingly challenging to implement largely due to cultural and policy issues. A general data sharing framework is presented along with two case studies that highlight these challenges and
Scott D. Kahn, Anne Koralova
doaj +1 more source
A new perspective on metformin therapy in type 1 diabetes [PDF]
, 2017 Metformin is quite frequently used off-label in type 1 diabetes to limit insulin dose requirement. Guidelines recommend that it can improve glucose control in those who are overweight and obese but evidence in support of this is limited.
Boyle, James G. +2 more
core +1 more source
β Cell and Autophagy: What Do We Know?
Biomolecules, 2023 Pancreatic β cells are central to glycemic regulation through insulin production. Studies show autophagy as an essential process in β cell function and fate.
Hamid-Reza Mohammadi-Motlagh +13 more
doaj +1 more source
Recent advances in understanding Type 1 Diabetes [version 1; referees: 2 approved]
F1000Research, 2016 Type 1 diabetes is a multifactorial disease in which genetic and environmental factors play a key role. The triggering event is still obscure, and so are many of the immune events that follow.
Gustaf Christoffersson +2 more
doaj +1 more source
Frontiers in Immunology, 2021 In human type 1 diabetes and animal models of the disease, a diverse assortment of immune cells infiltrates the pancreatic islets. CD8+ T cells are well represented within infiltrates and HLA multimer staining of pancreas sections provides clear evidence
Teresa Rodriguez-Calvo +9 more
doaj +1 more source
'Join us on our journey': Exploring the experiences of children and young people with type 1 diabetes and their parents [PDF]
, 2014 This paper focuses on children and young people with type 1 diabetes and on their parents, and their experiences of diabetes care provision. Nine acute hospitals in the Yorkshire and the Humber region, UK, were recruited to participate in a qualitative ...
Department of Health +16 more
core +1 more source
Long-term glycemic variability and risk of adverse outcomes: a systematic review and meta-analysis [PDF]
, 2015 OBJECTIVE: Glycemic variability is emerging as a measure of glycemic control, which may be a reliable predictor of complications. This systematic review and meta-analysis evaluates the association between HbA1c variability and micro- and macrovascular ...
Catherine Gorst +18 more
core +1 more source
Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
Nature Communications, 2016 Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a ...
Isabelle Serr +11 more
doaj +1 more source
A quantitative measure of treatment response in recent‐onset type 1 diabetes
Endocrinology, Diabetes & Metabolism, 2020 Introduction This paper develops a methodology and defines a measure that can be used to separate subjects that received an experimental therapy into those that benefitted from those that did not in recent‐onset type 1 diabetes.
Brian N. Bundy +2 more
doaj +1 more source