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A journey toward an open data culture through transformation of shared data into a data resource
Data & Policy, 2022 The transition to open data practices is straightforward albeit surprisingly challenging to implement largely due to cultural and policy issues. A general data sharing framework is presented along with two case studies that highlight these challenges and
Scott D. Kahn, Anne Koralova
doaj +1 more source
Codesigned Shared Decision-Making Diabetes Management Plan Tool for Adolescents With Type 1 Diabetes Mellitus and Their Parents: Prototype Development and Pilot Test [PDF]
, 2018 Background: Adolescents with type 1 diabetes mellitus have difficulty achieving optimal glycemic control, partly due to competing priorities that interfere with diabetes self-care.
Carroll, Aaron E. +7 more
core +1 more source
The emerging role of lncRNAs in inflammatory bowel disease
Experimental and Molecular Medicine, 2018 Inflammatory bowel disease: The role of noncoding RNA Studying long noncoding RNAs (lncRNAs) may improve diagnosis and treatment of inflammatory bowel disease (IBD).
Reza Yarani +3 more
doaj +1 more source
The TCF7L2locus and type 1 diabetes [PDF]
BMC Medical Genetics, 2007 TCF7L2 belongs to a subfamily of TCF7-like HMG box-containing transcription factors, and maps to human chromosome 10q25.3. A recent study identified genetic association of type 2 diabetes (T2D) with this gene, correlated with diminished insulin secretion.
Polychronakos Constantin, Qu Hui-Qi
openaire +3 more sources
β Cell and Autophagy: What Do We Know?
Biomolecules, 2023 Pancreatic β cells are central to glycemic regulation through insulin production. Studies show autophagy as an essential process in β cell function and fate.
Hamid-Reza Mohammadi-Motlagh +13 more
doaj +1 more source
Prevention of type 1 diabetes [PDF]
British Medical Bulletin, 2011 Type 1 diabetes is a chronic autoimmune condition characterized by destruction of insulin-producing β cells within the pancreatic islets. It is associated with considerable morbidity and mortality. Incidence levels are rising worldwide.Pubmed search (Nov 2010) using keywords: Type 1 diabetes, prevention, trials, immunotherapy.The causes of disease are ...
Thrower, SL, Bingley, PJ
openaire +3 more sources
Frontiers in Immunology, 2021 In human type 1 diabetes and animal models of the disease, a diverse assortment of immune cells infiltrates the pancreatic islets. CD8+ T cells are well represented within infiltrates and HLA multimer staining of pancreas sections provides clear evidence
Teresa Rodriguez-Calvo +9 more
doaj +1 more source
A new perspective on metformin therapy in type 1 diabetes [PDF]
, 2017 Metformin is quite frequently used off-label in type 1 diabetes to limit insulin dose requirement. Guidelines recommend that it can improve glucose control in those who are overweight and obese but evidence in support of this is limited.
Boyle, James G. +2 more
core +1 more source
BMJ, 2011 Type 1 diabetes in childhood is one of the commoner long term conditions of childhood. It is treated by specialist teams in secondary care using increasingly intensive insulin regimens, but the onset is generally diagnosed by primary care physicians, sometimes later than is ideal.
Ali, K, Harnden, A, Edge, J
openaire +5 more sources
Recent advances in understanding Type 1 Diabetes [version 1; referees: 2 approved]
F1000Research, 2016 Type 1 diabetes is a multifactorial disease in which genetic and environmental factors play a key role. The triggering event is still obscure, and so are many of the immune events that follow.
Gustaf Christoffersson +2 more
doaj +1 more source