Results 41 to 50 of about 2,373,806 (358)

Primary understanding of type 1 diabetes as an autoimmune disease

Saudi Journal for Health Sciences, 2022
Type 1 diabetes (T1D) is classified as an autoimmune disease affecting a wide range of people worldwide. Beta cells in the pancreatic islets of Langerhans in the pancreases are responsible for insulin productions, which help in the exchange of blood ...
Mohamd A Alblihed
doaj   +1 more source

Young people with type 1 diabetes and their transition to adult services. [PDF]

, 2013
More than 85% of children and young people with type 1 diabetes are not achieving the recommended target of
Kime, N
core   +1 more source

Urinary MicroRNA Profiling in the Nephropathy of Type 1 Diabetes [PDF]

, 2013
Background: Patients with Type 1 Diabetes (T1D) are particularly vulnerable to development of Diabetic nephropathy (DN) leading to End Stage Renal Disease.
A Krupa, A Micera, Analysis The Case for Objective Bayesian, AO Phillips, B John, Christos Argyropoulos, D Lunn, D Macconi, D Shan, David Galas, David Huang, Demetrius Ellis, DP Bartel, G Ghosh, G Togliatto, G Wang, G Wang, G Wang, H Guo, H Haller, H Sun, J Hou, JA Weber, JM Lorenzen, John Johnson, Jose Bernardo, K Bhatt, K Heese, K Sharma, Kai Wang, Karin Jandeleit-Dahm, L Denby, L Held, L Mahimainathan, L Matthews, M Ashburner, M Hackl, M Kato, M Kato, M Kato, ME Molitch, MW Pfaffl, O García-Sánchez, P Dentelli, P Kantharidis, P Ruggenenti, PE Pergola, R Bonofiglio, R Liao, RC Friedman, RC Gentleman, RC Lee, RW Carthew, S Fatima, Sara McClarty, SM Titan, SW Shan, T Roweis, Sam, TD Schmittgen, Trevor Orchard, U Tran, VA Valera, W Stacklies, X Wang, X-Y Bai, Y Dai, YS Kanwar, Z Chun-Zhi   +67 more
core   +7 more sources

Failure to Preserve β-Cell Function With Mycophenolate Mofetil and Daclizumab Combined Therapy in Patients With New- Onset Type 1 Diabetes [PDF]

, 2010
OBJECTIVE This trial tested whether mycophenolate mofetil (MMF) alone or with daclizumab (DZB) could arrest the loss of insulin-producing β-cells in subjects with new-onset type 1 diabetes.
Gottlieb, Peter A., Greenbaum, Carla J., Krause-Steinrauf, Heidi, Lachin, John M., Moran, Antoinette M., Quinlan, Scott, Rodriguez, Henry, Schatz, Desmond A., Skyler, Jay S., Type 1 Diabetes TrialNet MMF/DZB Study Group, Wilson, Darrell M.   +10 more
core   +2 more sources

miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes

Nature Communications, 2019
miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.
Martin G. Scherm, Isabelle Serr, Adam M. Zahm, Jonathan Schug, Saverio Bellusci, Rossella Manfredini, Victoria K. Salb, Katharina Gerlach, Benno Weigmann, Anette-Gabriele Ziegler, Klaus H. Kaestner, Carolin Daniel   +11 more
doaj   +1 more source

The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity

Molecular Metabolism, 2019
Background: microRNAs (miRNAs) have emerged as critical contributors to immune regulation and homeostasis, and their dysregulation is involved in the aberrant differentiation and function of T cell subsets.
Martin G. Scherm, Isabelle Serr, Klaus H. Kaestner, Carolin Daniel   +3 more
doaj   +1 more source

Does Type 1 Diabetes Affect Male Infertility: Type 1 Diabetes Exchange Registry-Based Analysis

Société Internationale d’Urologie Journal, 2021
IntroductionThe prevalence of type 1 diabetes (T1D) has been increasing over the last few decades and is commonly believed to negatively impact male fertility.
Omer A. Raheem, Marah C. Hehemann, Marc J. Rogers, Judy N. Fustok, Irl B. Hirsch, Thomas J. Walsh
doaj   +1 more source

Inhibition of pyrimidine de novo synthesis fosters Treg cells and reduces diabetes development in models of Type 1 Diabetes

Molecular Metabolism
Objective: In autoimmune Type 1 Diabetes (T1D), aberrant immune activation promotes regulatory T cell (Treg) impairments thereby boosting progression of islet autoimmunity.
Hannah Hipp, Camilla Tondello, Hanna Gmehling, Lena K. Scholz, Antigoni Stavridou, Maike Becker, Anne-Marie Bührer, Edith Hintermann, Sandra M. Dirschl, Till M. Johannsmann, Martin G. Scherm, Hella Kohlhof, Isabelle Serr, Urs Christen, Carolin Daniel   +14 more
doaj   +1 more source

Collagenase Isoforms for Pancreas Digestion

Cell Transplantation, 2009
The available information concerning the characteristics and composition of collagenase batches, which are effective in the digestion of human pancreas for islet transplants, is scarce and incomplete.
Federico Bertuzzi, Silvia Cainarca, Simona Marzorati, Angela Bachi, Barbara Antonioli, Rita Nano, Roberto Verzaro, Camillo Ricordi   +7 more
doaj   +1 more source

Type 1 diabetes and cardiovascular disease [PDF]

, 2013
The presence of cardiovascular disease (CVD) in Type 1 diabetes largely impairs life expectancy. Hyperglycemia leading to an increase in oxidative stress is considered to be the key pathophysiological factor of both micro- and macrovascular complications.
Cappuccio, Francesco, Ceriello, Antonio, Genovese, Stefano, Schnell, Oliver, Standl, E. (Eberhard), Valensi, Paul   +5 more
core   +2 more sources