Results 41 to 50 of about 2,183,210 (336)
Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials [PDF]
, 2017 OBJECTIVE: We assessed dysglycemia and a T1D Diagnostic Index60 (Index60) ≥1.00 (on the basis of fasting C-peptide, 60-min glucose, and 60-min C-peptide levels) as prediagnostic end points for type 1 diabetes among Type 1 Diabetes TrialNet Pathway to ...
Atkinson, Mark A. +14 more
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Does Type 1 Diabetes Affect Male Infertility: Type 1 Diabetes Exchange Registry-Based Analysis
Société Internationale d’Urologie Journal, 2021 IntroductionThe prevalence of type 1 diabetes (T1D) has been increasing over the last few decades and is commonly believed to negatively impact male fertility.
Omer A. Raheem, Marah C. Hehemann, Marc J. Rogers, Judy N. Fustok, Irl B. Hirsch, Thomas J. Walsh
doaj +1 more source
, 2007 It is well known that type 1 diabetes is a chronic autoimmune disease in which the breakdown of normal tolerance to the cell allows the activation of T cell to multiple antigens. This induces a progressive destruction of cells and a state of chronic insulin deficiency.
Chiarelli, Francesco, Giannini, Cosimo
openaire +3 more sources
Neutrophils in type 1 diabetes [PDF]
Journal of Diabetes Investigation, 2016 AbstractType 1 diabetes is an autoimmune disease that afflicts millions of people worldwide. It occurs as the consequence of destruction of insulin‐producing pancreatic β‐cells triggered by genetic and environmental factors. The initiation and progression of the disease involves a complicated interaction between β‐cells and immune cells of both innate ...
Juan Huang +3 more
openaire +2 more sources
A new perspective on metformin therapy in type 1 diabetes [PDF]
, 2017 Metformin is quite frequently used off-label in type 1 diabetes to limit insulin dose requirement. Guidelines recommend that it can improve glucose control in those who are overweight and obese but evidence in support of this is limited.
Boyle, James G. +2 more
core +1 more source
miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
Nature Communications, 2019 miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.
Martin G. Scherm +11 more
doaj +1 more source
Cell Transplantation, 2016 Type 1 diabetes (T1D) is characterized by destruction of glucose-responsive insulin-producing pancreatic β-cells and exhibits immune infiltration of pancreatic islets, where CD8 lymphocytes are most prominent.
Tobias Boettler +6 more
doaj +1 more source
Hypoglycemia in Type 1 Diabetes [PDF]
Diabetes, 2010 In subjects with type 1 diabetes, autoimmune destruction of pancreatic β-cells leads eventually to an absolute requirement for insulin replacement therapy. Insulin delivered exogenously is not subject to normal physiological feedback regulation, so it may induce hypoglycemia even in the presence of an intact counterregulatory response.
McCrimmon, Rory J., Sherwin, Robert S.
openaire +3 more sources
Collagenase Isoforms for Pancreas Digestion
Cell Transplantation, 2009 The available information concerning the characteristics and composition of collagenase batches, which are effective in the digestion of human pancreas for islet transplants, is scarce and incomplete.
Federico Bertuzzi +7 more
doaj +1 more source
Hospitalization for pneumonia is associated with decreased 1-year survival in patients with type 2 diabetes results from a prospective cohort study [PDF]
, 2016 Diabetes mellitus is a frequent comorbid conditions among patients with pneumonia living in the community. The aim of our study is to evaluate the impact of hospitalization for pneumonia on early (30 day) and late mortality (1 year) in patients with type
BERTAZZONI, Giuliano +12 more
core +1 more source