Results 61 to 70 of about 4,565,322 (357)

The TCF7L2locus and type 1 diabetes [PDF]

BMC Medical Genetics, 2007
TCF7L2 belongs to a subfamily of TCF7-like HMG box-containing transcription factors, and maps to human chromosome 10q25.3. A recent study identified genetic association of type 2 diabetes (T2D) with this gene, correlated with diminished insulin secretion.
Hui-Qi Qu, Constantin Polychronakos
openaire   +4 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Sample size requirements for studies of treatment effects on beta-cell function in newly diagnosed type 1 diabetes. [PDF]

PLoS ONE, 2011
Preservation of β-cell function as measured by stimulated C-peptide has recently been accepted as a therapeutic target for subjects with newly diagnosed type 1 diabetes.
John M Lachin, Paula L McGee, Carla J Greenbaum, Jerry Palmer, Mark D Pescovitz, Peter Gottlieb, Jay Skyler, Type 1 Diabetes Trial Network   +7 more
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Unleashing the potential of extracellular vesicles for ulcerative colitis and Crohn's disease therapy

Bioactive Materials
Inflammatory bowel disorders (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions of the gastrointestinal tract (GIT). They pose significant treatment challenges due to their complex etiology.
George Chigozie Njoku, Cathal Patrick Forkan, Fumie Mitani Soltysik, Peter Lindberg Nejsum, Flemming Pociot, Reza Yarani   +5 more
doaj   +1 more source

Study protocol of Diabetes LEAP: a longitudinal study examining emotional problems in adolescents with type 1 diabetes and their parents/caregivers

BMC Pediatrics, 2019
Background Type 1 diabetes (T1D) is a chronic metabolic condition requiring intensive daily self-care to avoid both high and low blood glucose levels.
Giesje Nefs, Linh Nguyen, Per Winterdijk, Esther Hartman, Theo Sas, Roos Nuboer, Ineke De Kruijff, Willie Bakker-van Waarde, Henk-Jan Aanstoot, Frans Pouwer   +9 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Could hypoxic conditioning augment the potential of mesenchymal stromal cell-derived extracellular vesicles as a treatment for type 1 diabetes?

Stem Cell Research & Therapy
Type1 Diabetes (T1D) is an autoimmune disorder characterised by the loss of pancreatic β-cells. This β cell loss occurs primarily through inflammatory pathways culminating in apoptosis.
Cathal Patrick Forkan, Aruna Shrestha, Alfred Yu, Christine Chuang, Flemming Pociot, Reza Yarani   +5 more
doaj   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Type 1 diabetes in children

BMJ, 2011
Type 1 diabetes in childhood is one of the commoner long term conditions of childhood. It is treated by specialist teams in secondary care using increasingly intensive insulin regimens, but the onset is generally diagnosed by primary care physicians, sometimes later than is ideal.
Ali, K, Harnden, A, Edge, J
openaire   +8 more sources