Results 61 to 70 of about 2,420,770 (348)

Urinary MicroRNA Profiling in the Nephropathy of Type 1 Diabetes [PDF]

, 2013
Background: Patients with Type 1 Diabetes (T1D) are particularly vulnerable to development of Diabetic nephropathy (DN) leading to End Stage Renal Disease.
A Krupa, A Micera, Analysis The Case for Objective Bayesian, AO Phillips, B John, Christos Argyropoulos, D Lunn, D Macconi, D Shan, David Galas, David Huang, Demetrius Ellis, DP Bartel, G Ghosh, G Togliatto, G Wang, G Wang, G Wang, H Guo, H Haller, H Sun, J Hou, JA Weber, JM Lorenzen, John Johnson, Jose Bernardo, K Bhatt, K Heese, K Sharma, Kai Wang, Karin Jandeleit-Dahm, L Denby, L Held, L Mahimainathan, L Matthews, M Ashburner, M Hackl, M Kato, M Kato, M Kato, ME Molitch, MW Pfaffl, O García-Sánchez, P Dentelli, P Kantharidis, P Ruggenenti, PE Pergola, R Bonofiglio, R Liao, RC Friedman, RC Gentleman, RC Lee, RW Carthew, S Fatima, Sara McClarty, SM Titan, SW Shan, T Roweis, Sam, TD Schmittgen, Trevor Orchard, U Tran, VA Valera, W Stacklies, X Wang, X-Y Bai, Y Dai, YS Kanwar, Z Chun-Zhi   +67 more
core   +3 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Adipose-derived mesenchymal stromal/stem cells in type 1 diabetes treatment

Communications Biology
Adipose tissue-derived mesenchymal stromal/stem cells (ADMSCs) represent a novel therapeutic intervention for Type 1 Diabetes (T1D). The attractiveness of ADMSCs is characterized by their immunomodulatory activities, regenerative properties, and relative
Vanshika Sood, Hannah Ricioli, George Chigozie Njoku, Rosita Primavera, Susana Dietrich, Avnesh S. Thakor, Flemming Pociot, Reza Yarani   +7 more
doaj   +1 more source

Gad65 is recognized by t-cells, but not by antibodies from nod-mice [PDF]

, 1994
Since the 64kDa-protein glutamic acid decarboxylase (GAD) is one of the major autoantigens in T-cell mediated Type 1 diabetes, its relevance as a T-cell antigen needs to be clarified. After isolation of splenic T-cells from non-obese diabetic (NOD) mice,
Alzari PM, Atkinson MA, Baekkeskov S, Bieg S, Christgau S, Christie MR, Diaz JL, Eisenbarth GS, Hackett CJ, Honeyman MC, J. Seissler, Jennings PA, L. Herberg, Leiter EH, Lie W, Mauch L, Miller LP, Ohneda A, Peters PJ, Roep BO, Roep BO, S. Bieg, Seissler J, Seissler J, Solimena M, Solimena M, Velloso LA, W. A. Scherbaum, W. Northemann   +28 more
core   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Regulatory T cells in the mouse hypothalamus control immune activation and ameliorate metabolic impairments in high-calorie environments

Nature Communications
The hypothalamus in the central nervous system (CNS) has important functions in controlling systemic metabolism. A calorie-rich diet triggers CNS immune activation, impairing metabolic control and promoting obesity and Type 2 Diabetes (T2D), but the ...
Maike Becker, Stefanie Kälin, Anne H. Neubig, Michael Lauber, Daria Opaleva, Hannah Hipp, Victoria K. Salb, Verena B. Ott, Beata Legutko, Roland E. Kälin, Markus Hippich, Martin G. Scherm, Lucas F. R. Nascimento, Isabelle Serr, Fabian Hosp, Alexei Nikolaev, Alma Mohebiany, Martin Krueger, Bianca Flachmeyer, Michael W. Pfaffl, Bettina Haase, Chun-Xia Yi, Sarah Dietzen, Tobias Bopp, Stephen C. Woods, Ari Waisman, Benno Weigmann, Matthias Mann, Matthias H. Tschöp, Carolin Daniel   +29 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Cohort profile: the ‘Biomarkers of heterogeneity in type 1 diabetes’ study—a national prospective cohort study of clinical and metabolic phenotyping of individuals with long-standing type 1 diabetes in the Netherlands

BMJ Open
Purpose The ‘Biomarkers of heterogeneity in type 1 diabetes’ study cohort was set up to identify genetic, physiological and psychosocial factors explaining the observed heterogeneity in disease progression and the development of complications in people ...
, Erwin Birnie, Giesje Nefs, Bruce H R Wolffenbuttel, Melanie M van der Klauw, Peter R van Dijk, Klaas Hoogenberg, Henk J Veeze, Henk-Jan Aanstoot, Bruce HR Wolffenbuttel, Charlotte E Vollenbrock, Pim Dekker, Lianne S M Boesten, Martine M C de Vries-Velraeds, Adriaan Kooy, Dick Mul, Sanjoy Dutta, Rita D M Varkevisser, Michael P Brugts, Petronella H L M Duijvestijn, Christine Fransman, Rob K Gonera, Esther Latres, Sandra Loves, Theo Sas, Marleen J Vosjan-Noeverman, Rita DM Varkevisser, Lianne SM Boesten, Peter R van Dijk, Petronella HLM Duijvestijn, Martine MC de Vries-Velraeds, Melanie M van der Klauw   +31 more
doaj   +1 more source

Behavioral Factors Influencing Health Outcomes in Youth with Type 1 Diabetes [PDF]

, 2012
The Pediatric Self-Management Model provides an overview of how behavioral factors influence children’s chronic medical illnesses. This general framework is used to organize the present review of how self-management behaviors, contextual factors, and ...
Kaugars, Astrida S., Kichler, Jessica C., Moss, Ashley   +2 more
core   +1 more source

Effectiveness of Groups for Adolescents With Type 1 Diabetes Mellitus and Their Parents [PDF]

, 2013
Peer- and family-based group therapies have been used as separate interventions to improve adjustment and self-management among youth with Type 1 diabetes mellitus.
Alemzadeh, Ramin, Kaugars, Astrida S., Kichler, Jessica C., Marik, Patricia, Nabors, Laura   +4 more
core   +2 more sources