Results 61 to 70 of about 2,183,210 (336)

Beta cell and immune cell interactions in autoimmune type 1 diabetes: How they meet and talk to each other

Molecular Metabolism, 2022
Background: The highly complex pathogenesis of Type 1 Diabetes is driven by several immune cell types with both effector and regulatory characteristics, which ultimately ends in the destruction of the insulin-producing beta cells.
Martin G. Scherm, Rebecca C. Wyatt, Isabelle Serr, David Anz, Sarah J. Richardson, Carolin Daniel   +5 more
doaj  

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Could hypoxic conditioning augment the potential of mesenchymal stromal cell-derived extracellular vesicles as a treatment for type 1 diabetes?

Stem Cell Research & Therapy
Type1 Diabetes (T1D) is an autoimmune disorder characterised by the loss of pancreatic β-cells. This β cell loss occurs primarily through inflammatory pathways culminating in apoptosis.
Cathal Patrick Forkan, Aruna Shrestha, Alfred Yu, Christine Chuang, Flemming Pociot, Reza Yarani   +5 more
doaj   +1 more source

Cohort profile: the ‘Biomarkers of heterogeneity in type 1 diabetes’ study—a national prospective cohort study of clinical and metabolic phenotyping of individuals with long-standing type 1 diabetes in the Netherlands

BMJ Open
Purpose The ‘Biomarkers of heterogeneity in type 1 diabetes’ study cohort was set up to identify genetic, physiological and psychosocial factors explaining the observed heterogeneity in disease progression and the development of complications in people ...
, Erwin Birnie, Giesje Nefs, Bruce H R Wolffenbuttel, Melanie M van der Klauw, Peter R van Dijk, Klaas Hoogenberg, Henk J Veeze, Henk-Jan Aanstoot, Bruce HR Wolffenbuttel, Charlotte E Vollenbrock, Pim Dekker, Lianne S M Boesten, Martine M C de Vries-Velraeds, Adriaan Kooy, Dick Mul, Sanjoy Dutta, Rita D M Varkevisser, Michael P Brugts, Petronella H L M Duijvestijn, Christine Fransman, Rob K Gonera, Esther Latres, Sandra Loves, Theo Sas, Marleen J Vosjan-Noeverman, Rita DM Varkevisser, Lianne SM Boesten, Peter R van Dijk, Petronella HLM Duijvestijn, Martine MC de Vries-Velraeds, Melanie M van der Klauw   +31 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Phase angle and body composition in long-term type 1 diabetes in adults: a comparative study in a Brazilian public reference outpatient clinic

Diabetology & Metabolic Syndrome
Introduction Type 1 Diabetes Mellitus (DM1) affects a small percentage of the population. Nevertheless, its prevalence is currently growing with alarming data on uncontrolled cases.
Natália Fenner-Pena, Virgínia Capistrano Fajardo, Lívia Froes, Paulo Augusto Miranda Carvalho, Fábio Vasconcellos Comim, Viviane Sahade, Márcio Weissheimer Lauria, Henrique Oswaldo da Gama Torres   +7 more
doaj   +1 more source

Can prevent type 1 diabetes?

Revista de la Sociedad Argentina de Diabetes, 2022
Type 1 diabetes (T1D) is caused by the autoimmune destruction of β cells of the pancreas, driven by CD4+ and CD8+ T lymphocytes. The humoral branch represented by B lymphocytes is responsible for producing autoantibodies (AAs) against specific antigens ...
Gustavo Frechtel
doaj   +1 more source

Type 1 diabetes in children

BMJ, 2011
Type 1 diabetes in childhood is one of the commoner long term conditions of childhood. It is treated by specialist teams in secondary care using increasingly intensive insulin regimens, but the onset is generally diagnosed by primary care physicians, sometimes later than is ideal.
Ali, K, Harnden, A, Edge, J
openaire   +8 more sources

Young people with type 1 diabetes and their transition to adult services. [PDF]

, 2013
More than 85% of children and young people with type 1 diabetes are not achieving the recommended target of
Kime, N
core   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source