Results 1 to 10 of about 32,025 (183)

Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin [PDF]

Cellular & Molecular Biology Letters
The skin is a barrier that protects the human body against environmental factors (physical, including solar radiation, chemicals, and pathogens). The integrity and, consequently, the effective metabolic activity of skin cells is ensured by the cell ...
Michał Biernacki, Elżbieta Skrzydlewska   +1 more
doaj   +2 more sources

Exploring the five-paced viper (Deinagkistrodon acutus) venom proteome by integrating a combinatorial peptide ligand library approach with shotgun LC-MS/MS

Journal of Venomous Animals and Toxins including Tropical Diseases, 2021
Background Snake venoms are complex mixtures of toxic proteins or peptides encoded by various gene families that function synergistically to incapacitate prey.
Xuekui Nie, Qiyi He, Bin Zhou, Dachun Huang, Junbo Chen, Qianzi Chen, Shuqing Yang, Xiaodong Yu   +7 more
doaj   +1 more source

Snake venomics of Bothrops punctatus, a semiarboreal pitviper species from Antioquia, Colombia [PDF]

PeerJ, 2014
Bothrops punctatus is an endangered, semi-arboreal pitviper species distributed in Panamá, Colombia, and Ecuador, whose venom is poorly characterized.
Maritza Fernández Culma, Jaime Andrés Pereañez, Vitelbina Núñez Rangel, Bruno Lomonte   +3 more
doaj   +2 more sources

Functional Characterization and Anti-Tumor Effect of a Novel Group II Secreted Phospholipase A₂ from Snake Venom of Saudi Cerastes cerates gasperetti

Molecules, 2023
Secreted phospholipases A2 are snake-venom proteins with many biological activities, notably anti-tumor activity. Phospholipases from the same snake type but different geographical locations have shown similar biochemical and biological activities with ...
Mona Alonazi, Najeh Krayem, Mona G. Alharbi, Arwa Ishaq A. Khayyat, Humidah Alanazi, Habib Horchani, Abir Ben Bacha   +6 more
doaj   +1 more source

Specific Changes in Arabidopsis thaliana Rosette Lipids during Freezing Can Be Associated with Freezing Tolerance

Metabolites, 2022
While the roles of a few specific lipids in plant freezing tolerance are understood, the effect of many plant lipids remains to be determined. Acclimation of plants to non-freezing cold before exposure to freezing temperatures improves the outcome of ...
Hieu Sy Vu, Sunitha Shiva, Thilani Samarakoon, Maoyin Li, Sujon Sarowar, Mary R. Roth, Pamela Tamura, Samuel Honey, Kaleb Lowe, Hollie Porras, Neema Prakash, Charles A. Roach, Morgan Stuke, Xuemin Wang, Jyoti Shah, Gary Gadbury, Haiyan Wang, Ruth Welti   +17 more
doaj   +1 more source

Antimicrobial activity of clofazimine is not dependent on mycobacterial C-type phospholipases [PDF]

Journal of Antimicrobial Chemotherapy, 2004
We have used a phospholipase C (PLC)-deletion mutant (plcABC) of the H37Rv strain of Mycobacterium tuberculosis (MTB), as well as a plcA-insertion mutant of Mycobacterium smegmatis, to investigate the possible involvement of PLCs in clofazimine-mediated inhibition of mycobacterial K(+) transport and growth. Inactivation of the PLCs of MTB and insertion
M C, Bopape, H C, Steel, R, Cockeran, N M, Matlola, P B, Fourie, R, Anderson   +5 more
openaire   +2 more sources

Membrane Lipid Derivatives: Roles of Arachidonic Acid and Its Metabolites in Pancreatic Physiology and Pathophysiology

Molecules, 2023
One of the most important constituents of the cell membrane is arachidonic acid. Lipids forming part of the cellular membrane can be metabolized in a variety of cellular types of the body by a family of enzymes termed phospholipases: phospholipase A2 ...
Cándido Ortiz-Placín, Alba Castillejo-Rufo, Matías Estarás, Antonio González   +3 more
doaj   +1 more source

Modification of phosphoinositides by the Shigella effector IpgD during host cell infection

Frontiers in Cellular and Infection Microbiology, 2022
Shigella, the causative agent of bacillary dysentery, subvert cytoskeletal and trafficking processes to invade and replicate in epithelial cells using an arsenal of bacterial effectors translocated through a type III secretion system. Here, we review the
Guy Tran Van Nhieu, Patricia Latour-Lambert, Jost Enninga   +2 more
doaj   +1 more source

Two Different Phospholipases C, Isc1 and Pgc1, Cooperate To Regulate Mitochondrial Function

Microbiology Spectrum, 2022
The absence of Isc1, the yeast homologue of mammalian neutral sphingomyelinase type 2, leads to severe mitochondrial dysfunction. We show that the deletion of another type C phospholipase, the phosphatidylglycerol (PG)-specific phospholipase Pgc1 ...
Maria Balazova, Petra Vesela, Lenka Babelova, Ivana Durisova, Paulina Kanovicova, Jakub Zahumensky, Jan Malinsky   +6 more
doaj   +1 more source

Properties of Clostridium Perfringens (Welch II) Type-A  -Toxin (Phospholipase c) Purified By Electrofocusing [PDF]

Journal of Medical Microbiology, 1974
SUMMARY Clostridium perfringens type-A α-toxin (phospholipase C) was purified on a preparative scale by a simple, rapid, two-stage procedure involving precipitation of culture-supernatant fluids with ammonium sulphate at 35 to 50% saturation, followed by isoelectric focusing in a pH 4·6 gradient.
C J, Smyth, J P, Arbuthnott
openaire   +2 more sources