Results 1 to 10 of about 510,182 (210)
Type I Interferon in Human Autoimmunity [PDF]
Frontiers in Immunology, 2014 The type I interferon system plays a critical role in host defense in health, and a growing body of literature suggests that type I interferon is a critical mediator of human autoimmune disease. Type I interferons function as a bridge between the innate and adaptive immune systems, and as such play an important role in setting thresholds for response ...
Timothy B. Niewold
doaj +4 more sources
Bunyaviruses and the Type I Interferon System [PDF]
Viruses, 2009 The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop plants. Despite being recognized as
Richard M. Elliott, Friedemann Weber
doaj +6 more sources
Cytotoxic lymphocytes counteract viral type I interferon immune evasion. [PDF]
PLoS PathogensViruses are recognized by host cell innate immunity through viral RNA/DNA sensing by cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING). However, many viruses evade cGAS-STING signaling and antiviral IFN-β response.
Michael Y Schakelaar +10 more
doaj +2 more sources
Context-dependent impact of type I interferon signaling in cancer [PDF]
Molecular CancerType I interferon (IFN) has long been known as a critical component of the molecular machinery that first responds to viral infection in multicellular eukaryotes.
Ainhoa Ruiz-Iglesias +3 more
doaj +2 more sources
Palmitoylation of TBK1 enhances the type I interferon signaling and strengthens anti-malarial immunity in mice [PDF]
Nature CommunicationsPrecise regulation of type I interferon signaling is crucial for effective immune defense against infectious diseases. However, the molecular mechanisms governing this pathway are not fully understood.
Zhongxin Han +10 more
doaj +2 more sources
Cloning of human Type I interferon cDNAs
Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, 2023 In the late 1970s, crude interferon samples were found to exhibit anti-tumour activity. This discovery led to the interferon as a “magic drug” for cancer patients.
Shigekazu NAGATA
doaj +1 more source
Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction
Viruses, 2021 Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression in neighboring cells to suppress virus replication. Type III IFNs have similar properties, however their effects are
Gennaro Iaconis +7 more
doaj +1 more source
Immunological Reviews, 2023 SummaryType I interferon (IFN) is a class of proinflammatory cytokines with a dual role on malignant transformation, tumor progression, and response to therapy. On the one hand, robust, acute, and resolving type I IFN responses have been shown to mediate prominent anticancer effects, reflecting not only their direct cytostatic/cytotoxic activity on (at
Peter Holicek +6 more
openaire +2 more sources
Evasion of Type I Interferon by SARS-CoV-2
Cell Reports, 2020 Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and host immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating viral evasion of immune response are lacking. Here, we use unbiased screening
Hongjie Xia +8 more
doaj +1 more source
Type I interferon–related kidney disorders
Kidney International, 2022 Type I interferon (IFN-I) mediates tissue damage in a wide range of kidney disorders, directly affecting the biology and function of several renal cell types including podocytes, mesangial, endothelial, and parietal epithelial cells. Enhanced IFN-I signaling is observed in the context of viral infections, autoimmunity (e.g., systemic lupus ...
Lodi, Lorenzo +7 more
openaire +4 more sources