Results 1 to 10 of about 1,669,550 (354)

Evasion of Type I Interferon by SARS-CoV-2

Cell Reports, 2020
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and host immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating viral evasion of immune response are lacking. Here, we use unbiased screening
Hongjie Xia, Zengguo Cao, Xuping Xie, Xianwen Zhang, John Yun-Chung Chen, Hualei Wang, Vineet D. Menachery, Ricardo Rajsbaum, Pei-Yong Shi   +8 more
doaj   +2 more sources

Interplay between SARS-CoV-2 and the type I interferon response.

PLoS Pathogens, 2020
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. An unbalanced immune response, characterized by a weak production of type I interferons (IFN-Is) and an exacerbated release of ...
Margarida Sa Ribero, Nolwenn Jouvenet, Marlène Dreux, Sébastien Nisole   +3 more
doaj   +2 more sources

Context-dependent impact of type I interferon signaling in cancer [PDF]

Molecular Cancer
Type I interferon (IFN) has long been known as a critical component of the molecular machinery that first responds to viral infection in multicellular eukaryotes.
Ainhoa Ruiz-Iglesias, Emma Guilbaud, Lorenzo Galluzzi, Santos Mañes   +3 more
doaj   +2 more sources

Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy*

Immunological Reviews, 2022
Pregnancy is a unique condition where the maternal immune system is continuously adapting in response to the stages of fetal development and signals from the environment.
Jiahui Ding, Anthony Maxwell, Nicholas K. Adzibolosu, Anna Hu, Yuan You, Aihua Liao, Gil Mor   +6 more
openalex   +3 more sources

Palmitoylation of TBK1 enhances the type I interferon signaling and strengthens anti-malarial immunity in mice [PDF]

Nature Communications
Precise regulation of type I interferon signaling is crucial for effective immune defense against infectious diseases. However, the molecular mechanisms governing this pathway are not fully understood.
Zhongxin Han, Siyi Xiong, Ke Zeng, Zilong Xiao, Liying Zhang, Yufen Zhang, Jiaying Guo, Wenqiang Peng, Yingchao Xie, Weiwei Liu, Xiao Yu   +10 more
doaj   +2 more sources

The Neglected Role of GSDMD C-Terminal in Counteracting Type I Interferon Signaling. [PDF]

Adv Sci (Weinh)
Xu W, He S, Shi W, Xu J, Liu S, Yu Z, Li D, Jin Q, Wang Y, Zhang Z, Lv Q, Ge Y, Li Y, Li X, Chen N, Fu X, Yang Y, Shi F.   +17 more
europepmc   +2 more sources

Cloning of human Type I interferon cDNAs

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, 2023
In the late 1970s, crude interferon samples were found to exhibit anti-tumour activity. This discovery led to the interferon as a “magic drug” for cancer patients.
Shigekazu NAGATA
doaj   +1 more source

Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction

Viruses, 2021
Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression in neighboring cells to suppress virus replication. Type III IFNs have similar properties, however their effects are
Gennaro Iaconis, Ben Jackson, Kay Childs, Mark Boyce, Stephen Goodbourn, Neil Blake, Miren Iturriza-Gomara, Julian Seago   +7 more
doaj   +1 more source

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Science, 2020
Interferons interfere with lung repair Interferons (IFNs) are central to antiviral immunity. Viral recognition elicits IFN production, which in turn triggers the transcription of IFN-stimulated genes (ISGs), which engage in various antiviral functions ...
J. Hadjadj, N. Yatim, L. Barnabei, A. Corneau, J. Boussier, Nikaïa Smith, H. Péré, B. Charbit, V. Bondet, C. Chenevier-Gobeaux, P. Breillat, Nicolas Carlier, R. Gauzit, C. Morbieu, F. Pène, N. Marin, N. Roche, T. Szwebel, S. Merkling, J. Treluyer, D. Veyer, L. Mouthon, C. Blanc, P. Tharaux, F. Rozenberg, A. Fischer, D. Duffy, F. Rieux-Laucat, S. Kernéis, B. Terrier   +29 more
semanticscholar   +1 more source

ADAR1 averts fatal type I interferon induction by ZBP1

Nature, 2022
Mutations of the ADAR1 gene encoding an RNA deaminase cause severe diseases associated with chronic activation of type I interferon (IFN) responses, including Aicardi–Goutières syndrome and bilateral striatal necrosis1–3.
Huipeng Jiao, Laurens Wachsmuth, Simone Wolf, Juliane Lohmann, M. Nagata, G. G. Kaya, N. Oikonomou, V. Kondylis, M. Rogg, M. Diebold, Simon E. Tröder, Branko Zevnik, M. Prinz, C. Schell, G. Young, G. Kassiotis, M. Pasparakis   +16 more
semanticscholar   +1 more source