Evasion of Type I Interferon by SARS-CoV-2
Cell Reports, 2020 Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and host immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating viral evasion of immune response are lacking. Here, we use unbiased screening
Hongjie Xia +8 more
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Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection [PDF]
, 2017 The requirement of type I interferon (IFN) for natural killer (NK) cell activation in response to viral infection is known, but the underlying mechanism remains unclear. Here, we demonstrate that type I IFN signaling in inflammatory monocytes, but not in
Amanda J. Lee +11 more
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Antiproliferative Properties of Type I and Type II Interferon [PDF]
Pharmaceuticals, 2010 The clinical possibilities of interferon (IFN) became apparent with early studies demonstrating that it was capable of inhibiting tumor cells in culture and in vivo using animal models.
Joseph Bekisz +4 more
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Interplay between SARS-CoV-2 and the type I interferon response.
PLoS Pathogens, 2020 The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. An unbalanced immune response, characterized by a weak production of type I interferons (IFN-Is) and an exacerbated release of ...
Margarida Sa Ribero +3 more
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Context-dependent impact of type I interferon signaling in cancer [PDF]
Molecular CancerType I interferon (IFN) has long been known as a critical component of the molecular machinery that first responds to viral infection in multicellular eukaryotes.
Ainhoa Ruiz-Iglesias +3 more
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Palmitoylation of TBK1 enhances the type I interferon signaling and strengthens anti-malarial immunity in mice [PDF]
Nature CommunicationsPrecise regulation of type I interferon signaling is crucial for effective immune defense against infectious diseases. However, the molecular mechanisms governing this pathway are not fully understood.
Zhongxin Han +10 more
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The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant [PDF]
, 2013 5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a potent type I interferon (IFN) inducer, was evaluated as a chemotherapeutic agent in mouse cancer models and proved to be well tolerated in human cancer clinical trials.
Akira, S +11 more
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<i>Pseudorabies Virus</i> IE180 Inhibits Virus Replication by Activating the Type I Interferon Pathway. [PDF]
MicroorganismsZheng F +7 more
europepmc +3 more sources
Cloning of human Type I interferon cDNAs
Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, 2023 In the late 1970s, crude interferon samples were found to exhibit anti-tumour activity. This discovery led to the interferon as a “magic drug” for cancer patients.
Shigekazu NAGATA
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Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction
Viruses, 2021 Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression in neighboring cells to suppress virus replication. Type III IFNs have similar properties, however their effects are
Gennaro Iaconis +7 more
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