Results 231 to 240 of about 1,669,550 (354)

Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription [PDF]

Haley M. Scott, Mackenzie H. Smith, Aja K. Coleman, Kaitlyn S. Armijo, Morgan J. Chapman, Summer L. Apostalo, Allison R. Wagner, Robert O. Watson, Kristin L. Patrick   +8 more
openalex   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells. [PDF]

Nat Immunol
Pucella JN, Maqueda-Alfaro RA, Ni H, Bandeira Sulczewski F, Eichinger A, Esteva E, Ra AC, Das A, Perez OA, Feng J, Stoeckius M, Smibert P, Khodadadi-Jamayran A, Dolgalev I, Ivanova E, Sota S, Cadwell K, Koralov SB, Zhong J, Soni C, Stetson DB, Weisberg SP, Farber DL, Idoyaga J, Reizis B.   +24 more
europepmc   +1 more source

MDA5 and MAVS Mediate Type I Interferon Responses to Coxsackie B Virus

, 2009
Jennifer Wang, Anna Cerny, Damon R. Asher, Evelyn A. Kurt‐Jones, Roderick T. Bronson, Robert W. Finberg   +5 more
openalex   +2 more sources

Association between human leucocyte antigen-DO polymorphisms and interferon/ribavirin treatment response in hepatitis C virus type 1 infection in Chinese population: a prospective study [PDF]

, 2018
Yinan Yao, Mei Liu, Feng Zang, Ming Yue, Xueshan Xia, Yue Feng, Haozhi Fan, Yun Zhang, Peng Huang, Rongbin Yu   +9 more
openalex   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

STING/type I interferon pathway is required for antigen-containing PLGA nanoparticle- and apoptotic cell-induced CD4+ T cell tolerance. [PDF]

Sci Adv
Podojil JR, Cogswell AC, Neef T, Chiang MY, Beddow SA, Arellano G, Kakade S, McCarthy DP, Elhofy A, Harp CT, Khan M, Meeks JJ, Xu D, Shea LD, Miller SD.   +14 more
europepmc   +1 more source

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, EarlyView.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source