Results 241 to 250 of about 1,669,550 (354)

Type I interferon signalling and interferon-responsive microglia in health and disease. [PDF]

FEBS J
Lopez-Atalaya JP, Bhojwani-Cabrera AM.
europepmc   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Publisher Correction: TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells. [PDF]

Nat Immunol
Arroyo Hornero R, Maqueda-Alfaro RA, Solís-Barbosa MA, Leylek RA, Medina Chavez O, Martinez OM, Gottfried-Blackmore A, Idoyaga J.   +7 more
europepmc   +1 more source

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

Acid ceramidase regulates CD8+ T-cell exhaustion via type I interferon-mediated upregulation of PD-L1. [PDF]

Front Immunol
Hu Z, Abdelrahman H, Elwy A, Kuang F, Dhiman S, Ali S, Marson M, Holnsteiner L, Hamdan TA, Friebus-Kardash J, Wiebeck E, Hansen W, Scheu S, Gulbins E, Lang PA, Lang KS, Lang J.   +16 more
europepmc   +1 more source

CD27 and ICOS as Targets of PD‐1/PD‐L1 Signaling to Regulate Resident Memory CD8+ T‐Cell‐Mediated Pulmonary Protection and Pathology

Advanced Science, EarlyView.
Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Yuanyuan Chen, Zhenzhen Wang, Liqiang Song, Qianqian Chen, Hang Zhang, Tao Pan, Jianli Pan, Sheng Zhao, Ting Shang, Hong'en Xu, Xing Lv, Jing Li, Fei Kang, Yongzhan Nie, Feng Zhao, Lei Shi, Zheng Wang   +16 more
wiley   +1 more source

Type I interferon limits interleukin-6 signalling in SLE through shedding interleukin-6 receptors. [PDF]

Rheumatology (Oxford)
Hempel M, Klapproth E, Krause A, Becker-Pauly C, Zeissig S, Heschel B, Weser N, Fantana J, Leuchten N, Rose-John S, El-Armouche A, Korb-Pap A, Aringer M.   +12 more
europepmc   +1 more source

Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity

, 2016
Timothy J. Nice, Lisa C. Osborne, Vesselin T. Tomov, David Artis, E. John Wherry, Herbert W. Virgin   +5 more
openalex   +2 more sources

The microbial metabolite desaminotyrosine protects from influenza through type I interferon

Science, 2017
Ashley L. Steed, G. Christophi, G. Kaiko, Lulu Sun, Victoria M. Goodwin, U. Jain, E. Esaulova, M. Artyomov, D. Morales, M. Holtzman, A. Boon, D. Lenschow, T. Stappenbeck   +12 more
semanticscholar   +1 more source

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source