Results 51 to 60 of about 1,669,550 (354)
<i>Pseudorabies Virus</i> IE180 Inhibits Virus Replication by Activating the Type I Interferon Pathway. [PDF]
MicroorganismsZheng F +7 more
europepmc +3 more sources
The type I interferon response in COVID-19: implications for treatment
Nature reviews. Immunology, 2020 Despite early reports to the contrary, there is increasing evidence that patients with severe COVID-19 have a robust type I interferon response, which contrasts with the delayed, possibly suppressed, interferon response seen early in infection.
Jeong Seok Lee, E. Shin
semanticscholar +1 more source
Type I Interferons in Host Defense [PDF]
Immunity, 2006 Type I interferons (IFNs) are a family of cytokines specialized to coordinate immunity to viruses and other intracellular infections. In the past several years, many of the receptors and signaling pathways that link pathogen detection to induction of type I IFNs have been identified and characterized.
Stetson, Daniel B., Medzhitov, Ruslan
openaire +2 more sources
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling
Social Science Research Network, 2020 Israelow et al. show that AAV-mediated expression of human ACE2 allows for SARS-CoV-2 infection and disease investigation in mice. This pathology is in part driven by type I interferon signaling, which recruits inflammatory immune cells without aborting ...
Benjamin Israelow +12 more
semanticscholar +1 more source
Type I interferons in infectious disease [PDF]
Nature Reviews Immunology, 2015 Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the induction of other mediators. Type I IFNs are important for host defence against viruses.
Finlay McNab +4 more
openaire +2 more sources
Nature Communications, 2021 Myeloid-derived suppressor cells (MDSC) are pathologically activated neutrophils and monocytes with potent immune suppressive activity. These cells play an important role in accelerating tumor progression and undermining the efficacy of anti-cancer ...
Kevin Alicea-Torres +19 more
semanticscholar +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A diverse array of gene products are effectors of the type I interferon antiviral response
Nature, 2011 The type I interferon response protects cells against invading viral pathogens. The cellular factors that mediate this defence are the products of interferon-stimulated genes (ISGs).
J. Schoggins +6 more
semanticscholar +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis
Clinical Microbiology Reviews, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a rapidly evolving pandemic worldwide with at least 68 million COVID-19-positive cases and a mortality rate of about 2.2%, as of 10 December 2020. In
Santhamani Ramasamy, S. Subbian
semanticscholar +1 more source