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Type III interferons prime neutrophils
Science, 2017Fungal Infection Type I interferons (IFNs) have a well-established role in antiviral immunity. Espinosa et al. found that type III IFNs (IFN-λs) play an essential role in driving antifungal responses. They studied immune responses to Aspergillus fumigatus in mice lacking receptors for type I or type III IFNs.
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Type I and III Interferon Production in Response to RNA Viruses
Journal of Interferon & Cytokine Research, 2014The biology of RNA viruses is closely linked to the type I and type III interferon (IFN) response of the host. These viruses display a range of molecular patterns that may be detected by host cells resulting in the induction of IFNs. Consequently, there are many examples of mechanisms employed by RNA viruses to block or delay IFN induction and reduce ...
Elizabeth, Reid, Bryan, Charleston
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Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis
Current Opinion in ImmunologyInterferon (IFN) was discovered based on interference with virus production, and three types of IFN are now defined. Since its discovery, IFN's roles have expanded beyond viruses to diverse pathogen types, tissue homeostasis, and inflammatory disease. The gastrointestinal (GI) tract is arguably the tissue where the roles of IFN types are most distinct,
Austin P, Wright, Timothy J, Nice
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Type III interferons (IFNs): Emerging Master Regulators of Immunity
2015Lambda interferons (IFN-λs), type III interferons or interleukins 28 and 29 are the latest addition to the class II cytokine family. They share low homology with the interferon (IFN) and IL-10 cytokine families, yet they exhibit common and unique activities, the full spectrum of which still remains incompletely understood.
Ioanna E, Galani +2 more
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Type III interferons in innate and adaptive immunity in the respiratory tract
Current Opinion in ImmunologyLambda interferons (IFNλs), also termed type III interferons (IFNs) or interleukins-28/29, have been in the shadow of type I IFNs for a long time. Their common induction mechanisms and signalling cascades with type I IFNs have made difficult the unwinding of their unique nonredundant functions.
Artemios Piperakis +2 more
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Type III interferon (IFN-lambda) antagonizes the antiviral activity of interferon-alpha in vitro.
Journal of biological regulators and homeostatic agents, 2014Type III interferons (IFN-lambda) are the most recently discovered members of IFN family. Synergism between different IFN types is well established, but for type I and type III IFNs no conclusive evidence has been reported so far. Possible synergism/antagonism between IFN-alpha and IFN-lambda in the inhibition of virus replication (EMCV, WNV lineage 1 ...
Capobianchi, M. R. +6 more
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Increased Sensitivity of SARS-CoV-2 to Type III Interferon in Human Intestinal Epithelial Cells
Journal of Virology, 2022Carmon Kee +2 more
exaly
Type III interferon activity in the brain
Cytokine, 2009Prasanthi Bandi +4 more
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