The Francisella Type VI Secretion System [PDF]
Frontiers in Cellular and Infection Microbiology, 2018 Francisella tularensisis subsp. tularensis is an intracellular bacterial pathogen and the causative agent of the life-threatening zoonotic disease tularemia.
Daniel L. Clemens +2 more
doaj +5 more sources
Diversification of the Type VI Secretion System in Agrobacteria
mBio, 2021 The T6SS is used by several taxa of Gram-negative bacteria to secrete toxic effector proteins to attack others. Diversification of effector collections shapes bacterial interactions and impacts the health of hosts and ecosystems in which bacteria reside.
Chih-Feng Wu +7 more
doaj +3 more sources
Type VI Secretion System in Pseudomonas aeruginosa: Secretion and Multimerization of VgrG Proteins [PDF]
The Journal of biological chemistry, 2011 Pseudomonas aeruginosa is a Gram-negative bacterium causing chronic infections in cystic fibrosis patients. Such infections are associated with an active type VI secretion system (T6SS), which consists of about 15 conserved components, including the AAA+
Abderrahman Hachani +45 more
core +11 more sources
Vibrio cholerae secretion system of the type VI
Проблемы особо опасных инфекций, 2022 The review summarizes literature data on the Vibrio cholerae secretion system of the 6th type. This system is a contact-dependent macromolecular mechanism through which bacteria translocate toxic effector proteins into target cells.
S. P. Zadnova +4 more
doaj +2 more sources
A New Front in Microbial Warfare—Delivery of Antifungal Effectors by the Type VI Secretion System [PDF]
Journal of Fungi, 2019 Microbes typically exist in mixed communities and display complex synergistic and antagonistic interactions. The Type VI secretion system (T6SS) is widespread in Gram-negative bacteria and represents a contractile nano-machine that can fire effector ...
Katharina Trunk +2 more
doaj +4 more sources
Structure and Activity of the Type VI Secretion System [PDF]
Microbiology Spectrum, 2019 The type VI secretion system (T6SS) is a multiprotein machine that uses a spring-like mechanism to inject effectors into target cells. The injection apparatus is composed of a baseplate on which is built a contractile tail tube/sheath complex.
Y. Cherrak +4 more
semanticscholar +3 more sources
A DNase Type VI Secretion System Effector Requires Its MIX Domain for Secretion
Microbiology Spectrum, 2022 Gram-negative bacteria often employ the type VI secretion system (T6SS) to deliver diverse cocktails of antibacterial effectors into rival bacteria.
Chaya Mushka Fridman +4 more
doaj +3 more sources
Comprehensive analysis of the type VI secretion system in Neisseria: identification, distribution, and evolutionary insights [PDF]
BMC GenomicsThe genus Neisseria, a gram-negative diplococcus, includes commensal and pathogenic species that infect mucosal tissues, causing diseases such as gonorrhea and meningitis.
Tingting Dong +10 more
doaj +2 more sources
Structure and assembly of type VI secretion system cargo delivery vehicle
Cell Reports, 2023 Summary: Type VI secretion system is widely used in Gram-negative bacteria for injecting toxic effectors into neighboring prokaryotic or eukaryotic cells.
Wenbo He +16 more
doaj +2 more sources
A widespread accessory protein family diversifies the effector repertoire of the type VI secretion system spike. [PDF]
Nat CommunType VI secretion systems (T6SSs) are macromolecular assemblies that deliver toxic effector proteins between adjacent bacteria. These effectors span a wide range of protein families that all lack canonical signal sequences that would target them for ...
Colautti J +6 more
europepmc +2 more sources