Results 21 to 30 of about 24,060,770 (296)

Type VI Secretion Systems and the Gut Microbiota [PDF]

Microbiology Spectrum, 2019
ABSTRACT The human colonic microbiota is a dense ecosystem comprised of numerous microbes, including bacteria, phage, fungi, archaea, and protozoa, that compete for nutrients and space. Studies are beginning to reveal the antagonistic mechanisms that gut bacteria use to compete with other members of this ecosystem. In the healthy
Michael J, Coyne, Laurie E, Comstock
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Type VI secretion system in Pseudomonas aeruginosa: secretion and multimerization of VgrG proteins. [PDF]

The Journal of biological chemistry, 2011
Pseudomonas aeruginosa is a Gram-negative bacterium causing chronic infections in cystic fibrosis patients. Such infections are associated with an active type VI secretion system (T6SS), which consists of about 15 conserved components, including the AAA+ ATPase, ClpV. The T6SS secretes two categories of proteins, VgrG and Hcp.
Hachani, Abderrahman, Lossi, Nadine S, Hamilton, Alexander, Jones, Cerith, Bleves, Sophie, Albesa-Jové, David, Filloux, Alain   +6 more
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Structural biology of type VI secretion systems [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2012
Type VI secretion systems (T6SSs) are transenvelope complexes specialized in the transport of proteins or domains directly into target cells. These systems are versatile as they can target either eukaryotic host cells and therefore modulate the bacteria–host interaction and pathogenesis or bacterial cells and therefore facilitate access to a specific ...
Cascales, E., Cambillau, Christian
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Marker for type VI secretion system effectors [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance The recently discovered type VI secretion system (T6SS) is used by Gram-negative bacteria to deliver effector proteins into both eukaryotic and prokaryotic neighboring cells to mediate virulence and competition, respectively.
Dor, Salomon, Lisa N, Kinch, David C, Trudgian, Xiaofeng, Guo, John A, Klimko, Nick V, Grishin, Hamid, Mirzaei, Kim, Orth   +7 more
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Structure and Regulation of the Type VI Secretion System [PDF]

Annual Review of Microbiology, 2012
The type VI secretion system (T6SS) is a complex and widespread gram-negative bacterial export pathway with the capacity to translocate protein effectors into a diversity of target cell types. Current structural models of the T6SS indicate that the apparatus is composed of at least two complexes, a dynamic bacteriophage-like structure and a cell ...
Silverman, Julie, Brunet, Yannick, Cascales, E., Mougous, Joseph   +3 more
openaire   +2 more sources

Type VI secretion: a beginner's guide [PDF]

, 2008
Type VI secretion is a newly described mechanism for protein transport across the cell envelope of Gram-negative bacteria. Components that have been partially characterised include an IcmF homologue, the ATPase ClpV, a regulatory FHA domain protein and ...
Bailey, Christopher, Bailey, Christopher M., Bingle, Lewis E. H., Bailey, Christopher M, Pallen, Mark J, Pallen, Mark J., Bingle, Lewis, Pallen, Mark   +7 more
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Structure of the Type VI Secretion System Contractile Sheath [PDF]

Cell, 2015
Bacteria use rapid contraction of a long sheath of the type VI secretion system (T6SS) to deliver effectors into a target cell. Here, we present an atomic-resolution structure of a native contracted Vibrio cholerae sheath determined by cryo-electron microscopy. The sheath subunits, composed of tightly interacting proteins VipA and VipB, assemble into a
Kudryashev, Mikhail, Wang, Ray Yu-Ruei, Brackmann, Maximilian, Scherer, Sebastian, Maier, Timm, Baker, David, DiMaio, Frank, Stahlberg, Henning, Egelman, Edward H., Basler, Marek   +9 more
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Established microbial colonies can survive type VI secretion assault [PDF]

, 2015
Type VI secretion (T6S) is a cell-to-cell injection system that can be used as a microbial weapon. T6S kills vulnerable cells, and is present in close to 25% of sequenced Gram-negative bacteria.
Ned S Wingreen, Marek Basler (173162), Basler, Marek, Ringel, Peter, David Bruce Borenstein, Peter Ringel (816293), Borenstein, David Bruce, Peter Ringel, Wingreen, Ned S., Wingreen, Ned, Marek Basler, David Bruce Borenstein (413437), Ned S. Wingreen (10926)   +12 more
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Trade-offs constrain adaptive pathways to type VI secretion system survival

iScience, 2023
Summary: The Type VI Secretion System (T6SS) is a nano-harpoon used by many bacteria to inject toxins into neighboring cells. While much is understood about mechanisms of T6SS-mediated toxicity, less is known about the ways that competitors can defend ...
Kathryn A. MacGillivray, Siu Lung Ng, Sophia Wiesenfeld, Randi L. Guest, Tahrima Jubery, Thomas J. Silhavy, William C. Ratcliff, Brian K. Hammer   +7 more
doaj   +1 more source

Distribution and diversity of bacterial secretion systems across metagenomic datasets [PDF]

, 2012
Bacteria can manipulate their surrounding environment through the secretion of proteins into other living organisms and into the extracellular milieu. In Gram stain negative bacteria this process is mediated by different types of secretion systems from ...
Egan, Frank, O’Gara, Fergal, Barret, Matthieu, O'Gara, Fergal   +3 more
core   +1 more source