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The Francisella Type VI Secretion System [PDF]
Frontiers in Cellular and Infection Microbiology, 2018 Francisella tularensisis subsp. tularensis is an intracellular bacterial pathogen and the causative agent of the life-threatening zoonotic disease tularemia.
Daniel L. Clemens +2 more
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Structure and Activity of the Type VI Secretion System [PDF]
Microbiology Spectrum, 2019 International audienceThe type VI secretion system (T6SS) is a multiprotein machine that uses a spring-like mechanism to inject effectors into target cells.
Durand, Eric +5 more
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The type VI secretion system: a tubular story [PDF]
The EMBO Journal, 2009 The molecular mechanism by which proteins are secreted in gram-negative bacteria is supported by nanomachines called type I to type VI secretion systems (T1SS to T6SS).
Filloux, Alain, Alain Filloux
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Adaptor proteins of type VI secretion system effectors [PDF]
Trends in Microbiology, 2016 Bacteria use the type VI secretion system (T6SS) to kill neighboring cells. One key feature of the T6SS is the secretion of diverse effectors. Here, we discuss six publications that describe three superfamilies of T6SS proteins, each dedicated to mediate
Unterweger, D +3 more
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Tagging the type VI secretion system [PDF]
Nature Microbiology, 2018 International audienceBacteria use multiple mechanisms to secrete proteins across their envelope and gain access to resources in their niche. The type VI secretion system (T6SS) specializes in injecting toxic protein effectors by direct contact, killing ...
Francetic, Olivera
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Presence and absence of type VI secretion systems in bacteria [PDF]
Microbiology (Reading, England), 2022 The type VI secretion system (T6SS) is a molecular puncturing device that enables Gram-negative bacteria to kill competitors, manipulate host cells and take up nutrients. Who would want to miss such superpowers?
Unterweger, D. ; https://orcid.org/ +4 more
core +5 more sources
A binary effector module secreted by a type VI secretion system [PDF]
The EMBO Reports, 2021 ABSTRACT Gram-negative bacteria use type VI secretion systems (T6SSs) to deliver toxic effector proteins into neighboring cells. Cargo effectors are secreted by binding non-covalently to the T6SS apparatus. Occasionally, effector secretion is assisted by an adaptor protein, although the adaptor itself is not secreted.
Dar, Yasmin +3 more
openaire +3 more sources
Secretin interactions in the type II secretion system [PDF]
, 2012 PhDThe type II secretion system (T2SS) is the major terminal branch of the general secretory pathway. It is composed of 12-15 proteins, most in multiple copies, and spans the inner and outer membranes of Gram-negative bacteria.
Gu, Shuang
core +4 more sources
Type VI secretion system [PDF]
Current Biology, 2015 Bacteria employ a variety of tools to survive in a competitive environment. Salomon and Orth describe one such tool-the Type 6 Secretion Systems used by bacteria to deliver a variety of toxins into competing cells.
Salomon, Dor, Orth, Kim
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The Versatile Type VI Secretion System [PDF]
Microbiology Spectrum, 2016 ABSTRACT Bacterial type VI secretion systems (T6SSs) function as contractile nanomachines to puncture target cells and deliver lethal effectors. In the 10 years since the discovery of the T6SS, much has been learned about the structure and function of this versatile protein secretion apparatus.
Christopher J, Alteri, Harry L T, Mobley
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