Mechanisms of Pseudomonas aeruginosa resistance to type VI secretion system attacks [PDF]
Nature CommunicationsThe Type VI Secretion System (T6SS) is a molecular nanomachine that injects toxic effector proteins into the environment or neighboring cells, playing an important role in interbacterial competition and host antagonism during infection.
Alejandro Tejada-Arranz +6 more
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Crosstalk Between Type VI Secretion System and Mobile Genetic Elements [PDF]
Frontiers in Molecular Biosciences, 2019 Many bacterial processes require cell-cell contacts. Such are the cases of bacterial conjugation, one of the main horizontal gene transfer mechanisms that physically spreads DNA, and the type VI secretion systems (T6SSs), which deploy antibacterial ...
Arancha Peñil-Celis +1 more
doaj +4 more sources
The role of the type VI secretion system in the stress resistance of plant-associated bacteria. [PDF]
Stress BiolThe type VI secretion system (T6SS) is a powerful bacterial molecular weapon that can inject effector proteins into prokaryotic or eukaryotic cells, thereby participating in the competition between bacteria and improving bacterial environmental ...
Yin R, Cheng J, Lin J.
europepmc +2 more sources
The Vibrio type VI secretion system induces intestinal macrophage redistribution and enhanced intestinal motility [PDF]
mBioIntestinal microbes, whether resident or transient, influence the physiology of their hosts, altering both the chemical and the physical characteristics of the gut. An example of the latter is the human pathogen Vibrio cholerae’s ability to induce strong
Julia S. Ngo +6 more
doaj +2 more sources
Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria.
PLoS Pathogens, 2015 The type VI secretion system (T6SS) is a widespread protein secretion apparatus used by Gram-negative bacteria to deliver toxic effector proteins into adjacent bacterial or host cells.
Dor Salomon +6 more
doaj +4 more sources
Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation [PDF]
BMC Genomics, 2019 Background Klebsiella pneumoniae (KP) is an opportunistic pathogen that mainly causes respiratory and urinary tract infections. The frequent occurrence of simultaneously virulent and multiple drug-resistant isolates led WHO to include this species in the
Victor Augusto Araújo Barbosa +1 more
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Collective protection against the type VI secretion system in bacteria
The ISME Journal, 2022 Bacteria commonly face attacks from other strains using the type VI secretion system (T6SS), which acts like a molecular speargun to stab and intoxicate competitors.
E. Granato +2 more
semanticscholar +5 more sources
Acinetobacter baumannii represses type VI secretion system through a manganese-dependent small RNA-mediated regulation. [PDF]
mBioType VI secretion system (T6SS) is utilized by many Gram-negative bacteria to eliminate competing bacterial species and manipulate host cells. Acinetobacter baumannii ATCC 17978 utilizes T6SS at the expense of losing pAB3 plasmid to induce contact ...
Bhowmik S +11 more
europepmc +2 more sources
Type VI secretion system effectors: poisons with a purpose [PDF]
Nature Reviews Microbiology, 2014 The type VI secretion system (T6SS) mediates interactions between a broad range of Gram-negative bacterial species. Recent studies have led to a substantial increase in the number of characterized T6SS effector proteins and a more complete and nuanced view of the adaptive importance of the system.
Alistair B. Russell +2 more
semanticscholar +3 more sources
Structure of the type VI secretion system contractile sheath. [PDF]
Cell, 2015 Bacteria use rapid contraction of a long sheath of the type VI secretion system (T6SS) to deliver effectors into a target cell. Here, we present an atomic-resolution structure of a native contracted Vibrio cholerae sheath determined by cryo-electron microscopy. The sheath subunits, composed of tightly interacting proteins VipA and VipB, assemble into a
M. Kudryashev +9 more
semanticscholar +5 more sources