Results 81 to 90 of about 259,068 (324)

Bacterial symbionts use a type VI secretion system to eliminate competitors in their natural host

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Competition among cooccurring bacteria can change the structure and function of a microbial community. However, little is known about the molecular mechanisms that impact such interactions in vivo.
Lauren Speare, Andrew G. Cecere, Kirsten R. Guckes, Stephanie Smith, M. S. Wollenberg, Mark J. Mandel, Tim I. Miyashiro, A. Septer   +7 more
semanticscholar   +1 more source

Historical account on gaining insights on the mechanism of crown gall tumorigenesis induced by Agrobacterium tumefaciens

Frontiers in Microbiology, 2014
The plant tumor disease, known as crown gall, was not called by that name until more recent times. Tumors on plants, particularly on cultivated grapevines, were observed thousands of years ago and recorded in the bible (wine was being made 7000 years ...
Clarence I. Kado
doaj   +1 more source

Bacterial rotary export ATPases are allosterically regulated by the nucleotide second messenger cyclic-di-GMP [PDF]

, 2015
The widespread second messenger molecule cyclic di-GMP (cdG) regulates the transition from motile and virulent lifestyles to sessile, biofilm-forming ones in a wide range of bacteria. Many pathogenic and commensal bacterial-host interactions are known to
Abel, Aldridge, Amikam, Aragón, Barahona, Baraquet, Bell, Benach, Bingle, Boehm, Boyd, Brencic, Christen, Clare E.M. Stevenson, Compant, Cuppels, David M. Lawson, De, Duerig, Eleftheria Trampari, Emsley, Engl, Fazli, Gal, Galibert, Gledhill, Haas, Hengge, Hickman, Ho, Hughes, Iino, Imada, Jacob G. Malone, Jonas, Kelley, Krasteva, Krissinel, Kuchma, Kuchma, Kulasakara, Lee, Lindeberg, Little, Lovering, Lucchini, Lugtenberg, Macnab, Macnab, Martínez-Granero, Matilla, McNicholas, Miller, Minamino, Minamino, Minamino, Minamino, Minamino, Minamino, Minamino, Minamino, Moscoso, Moscoso, Naseby, Navazo, Nesper, Newell, Newell, Pfeilmeier, Pultz, Pérez-Mendoza, Qi, Rainey, Richard H. Little, Roelofs, Ryan, Schirmer, Solano, Srivastava, Starkey, Steiner, Story, Sudarsan, Tchigvintsev, Thomas Wilhelm, Tschowri, Wassmann, Wilhelm, Woodcock, Xin   +89 more
core   +1 more source

Diversity and prevalence of type VI secretion system effectors in clinical Pseudomonas aeruginosa isolates

Frontiers in Microbiology, 2023
Pseudomonas aeruginosa is an opportunistic pathogen and a major driver of morbidity and mortality in people with Cystic Fibrosis (CF). The Type VI secretion system (T6SS) is a molecular nanomachine that translocates effectors across the bacterial ...
Luca A Robinson, Alice C. Z. Collins, R. Murphy, J. Davies, L. Allsopp   +4 more
semanticscholar   +1 more source

Mesenteric Adipose Tissue‐Derived Klebsiella variicola Disrupts Intestinal Barrier and Promotes Colitis by Type VI Secretion System

Advancement of science, 2023
Mesenteric adipose tissue (MAT) in Crohn's disease (CD) is associated with transmural inflammation. Extended mesenteric excision can reduce surgical recurrence and improve long‐term outcomes, indicating that MAT plays an important role in the ...
Junli Gong, Jing Yu, Shengmei Yin, J. Ke, Jinjie Wu, Chen Liu, Zhanhao Luo, Wai Ming Cheng, Yaozu Xie, Yuan Chen, Zhen He, P. Lan   +11 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Roles of Type VI Secretion System in Transport of Metal Ions

Frontiers in Microbiology, 2021
The type VI secretion system (T6SS) is a transmembrane protein nanomachine employed by many gram-negative bacteria to directly translocate effectors into adjacent cells or the extracellular milieu, showing multiple functions in both interbacterial ...
Xiaobing Yang, Xiaobing Yang, Hai Liu, Yanxiong Zhang, Xihui Shen   +4 more
doaj   +1 more source

Assessing toxicity and competitive fitness of Vibrio isolates from coastal waters in Israel

mSphere
Several species of aquatic bacteria belonging to the genus Vibrio are emerging pathogens of humans and marine animals. Vibrio-associated infections have been shown to correlate with the increase in the oceans’ surface water temperatures.
Katarzyna Kanarek, Kinga Keppel, Hadar Cohen, Chaya Mushka Fridman, Motti Gerlic, Dor Salomon   +5 more
doaj   +1 more source

The evolution of the type VI secretion system as a disintegration weapon

PLoS Biology, 2020
The type VI secretion system (T6SS) is a nanomachine used by many bacteria to drive a toxin-laden needle into other bacterial cells. Although the potential to influence bacterial competition is clear, the fitness impacts of wielding a T6SS are not well ...
William P. J. Smith, Andrea Vettiger, J. Winter, Till Ryser, L. Comstock, Marek Basler, K. Foster   +6 more
semanticscholar   +1 more source