Results 31 to 40 of about 63,697 (228)

Hydroxamic Acid as a Potent Metal-Binding Group for Inhibiting Tyrosinase

Antioxidants, 2022
Tyrosinase, a metalloenzyme containing a dicopper cofactor, plays a central role in synthesizing melanin from tyrosine. Many studies have aimed to identify small-molecule inhibitors of tyrosinase for pharmaceutical, cosmetic, and agricultural purposes ...
Joonhyeok Choi, Trilok Neupane, Rishiram Baral, Jun-Goo Jee   +3 more
doaj   +1 more source

Clinical Trials of Immunogene Therapy for Spontaneous Tumors in Companion Animals [PDF]

, 2014
Despite the important progress obtained in the treatment of some pets’ malignancies, new treatments need to be developed. Being critical in cancer control and progression, the immune system’s appropriate modulation may provide effective therapeutic ...
Finocchiaro, Liliana Maria Elena, Glikin, Gerardo Claudio   +1 more
core   +4 more sources

Chemical characterization and biological properties of royal jelly samples from the mediterranean area [PDF]

, 2020
Royal jelly (RJ) is a bee product that has high nutritional value and is beneficial for the human health, earning importance as a functional food. Thus, the characterization of its main biological properties is with high importance.
AAZZA, Smail, EL-GEUNDOUZ, Soukaina, Figueiredo, A. Cristina, Lyoussi, Badiaa, Machado, Alexandra M., Mateus, Maria, Miguel, Maria   +6 more
core   +1 more source

The nature of tyrosinase [PDF]

Biochemical Journal, 1931
The view that tyrosinase is a mixture of a number of components has been held by several investigators. Haehn [1920] reported that potato tyrosinase lost its activity on dialysis or ultrafiltration, but regained it on addition of the ultrafiltrate or boiled juice. He concluded that the activator was inorganic in nature.
D, Narayanamurti, C V, Ramaswami
openaire   +2 more sources

Tyrosinase inhibitors as melanoma sensitizers: Boosting therapeutic efficacy

Supramolecular Materials
Melanoma therapy faces critical challenges due to melanin-mediated resistance mechanisms. The use of tyrosinase inhibitors to suppress tyrosinase activity and reduce melanogenesis, thereby sensitizing melanoma cells, represents a highly promising ...
Yongsheng Li, Kan Yang, Luyang Zhao
doaj   +1 more source

Interaction of human heat shock protein 70 with tumor-associated peptides [PDF]

, 2009
Molecular chaperones of the heat shock protein 70 (Hsp70) family play a crucial role in the presentation of exogenous antigenic peptides by antigen-presenting cells (APCs).
Bendz, Bendz, Bernhardt, Bernhardt, Calderwood, Calderwood, Carilli, Carilli, Castellino, Castellino, Davis, Davis, Elguindi, Elguindi, Farr, Farr, Fernández, Fernández, Flechtner, Flechtner, Flynn, Flynn, Fourie, Fourie, Germeroth, Germeroth, Gragerov, Gragerov, Hartl, Hartl, Ishii, Ishii, Kawakami, Kawakami, Kelley, Kelley, Knarr, Knarr, Laemmli, Laemmli, Landry, Landry, Mayer, Mayer, Mayer, Mayer, Mayer, Mayer, McCarty, McCarty, Milani, Milani, Moroi, Moroi, Multhoff, Multhoff, Noessner, Noessner, Norby, Norby, Stevens, Stevens, Suto, Suto, Takeda, Takeda, Udono, Udono, Udono, Udono, Ueda, Ueda, Visseren, Visseren, Wegele, Wegele, Wölfel, Wölfel, Zheng, Zheng, Zhu, Zhu   +81 more
core   +1 more source

Control Strategies in Guanine Biocrystallization

Angewandte Chemie, EarlyView.
Biological guanine crystals produce spectacular photonic phenomena in animals and hold great promise as new, sustainable optical materials. We review how organisms precisely control the structure, morphologies, and resulting optical properties of these crystals using a set of ingenious ‘design’ strategies, including control of pH, template‐directed ...
Shashanka S. Indri, Avital Wagner, Benjamin A. Palmer   +2 more
wiley   +2 more sources

Inhibition mechanism investigation of quercetagetin as a potential tyrosinase inhibitor

Frontiers in Chemistry
Tyrosinase is one important rate limiting enzyme in melanin synthesis, directly affecting the melanin synthesis. Quercetagetin is one active ingredient from marigold.
Faliang Liang
doaj   +1 more source

Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Melanogenesis is a process to synthesize melanin, which is a primary responsible for the pigmentation of human skin, eye and hair. Although numerous enzymatic catalyzed and chemical reactions are involved in melanogenesis process, the enzymes such as ...
Thanigaimalai Pillaiyar, Manoj Manickam, Vigneshwaran Namasivayam   +2 more
doaj   +1 more source

Biochemical Properties of Tyrosinase from Aspergillus terreus and Penicillium copticola; Undecanoic Acid from Aspergillus flavus, an Endophyte of Moringa oleifera, Is a Novel Potent Tyrosinase Inhibitor

Molecules, 2021
Tyrosinase is a copper-containing monooxygenase catalyzing the O-hydroxylation of tyrosine to 3,4-dihydroxyphenylalanine then to dopaquinone that is profoundly involved in melanin synthesis in eukaryotes.
Hanaa Salah Maamoun, Gamal H. Rabie, Ibrahim Shaker, Bothaina A. Alaidaroos, Ashraf S. A. El-Sayed   +4 more
doaj   +1 more source