Results 141 to 150 of about 12,040 (235)

Discovery of bis-thiourea derivatives as potent tyrosinase inhibitors: combined experimental and computational study

Journal of Enzyme Inhibition and Medicinal Chemistry
Tyrosinase, a key enzyme in melanin synthesis, serves as a primary target for developing depigmenting agents. The search for novel tyrosinase inhibitors is needed due to the adverse effects of current inhibitors.
Sahachai Sabuakham, Sutita Nasoontorn, Napat Nuramrum, Atit Silsirivanit, Thanyada Rungrotmongkol, Ratchanok Pingaew, Panupong Mahalapbutr   +6 more
doaj   +1 more source

Melanosomes as Antigen‐Presenting Decoys in Melanoma Immune Evasion

MedComm, Volume 7, Issue 7, July 2026.
Yingqi Kuang, Fangfang Zhou
wiley   +1 more source

Cannabidiol-Based Thiosemicarbazones: A Preliminary Study Evaluating Their Anti-Tyrosinase Properties

Molecules
Cannabidiol (CBD), a non-psychoactive cannabinoid, has attracted significant research interest due to its antioxidant, anti-inflammatory, and neuroprotective properties.
Eliav Peretz, Noa Ashkenazi, Sanaa Musa
doaj   +1 more source

Tyrosinase inhibitory activity of supernatant and semi-purified extracts from squid pen fermented with Burkholderia cepacia TKU025

, 2014
Reports of tyrosinase inhibitors from microorganisms are rare. The tyrosinase inhibitory activity was found from the culture supernatant of Burkholderia cepacia TKU025 with 1 % squid pen as the sole carbon/nitrogen source.
Liang, Tzu-Wen, Wang, San-Lang
core   +1 more source

Nitrophenylpiperazine derivatives as novel tyrosinase inhibitors: design, synthesis, and in silico evaluations

BMC Chemistry
A novel series of 4-nitrophenylpiperazine derivatives (4a–m) was designed and synthesized as potential tyrosinase inhibitors. Comprehensive characterization using 1H-NMR, 13C-NMR, CNH, and IR techniques was performed for all target compounds ...
Mehdi Asadi, Fahime Fayazi, Aida Iraji, Reyhaneh Sabourian, Homa Azizian, Mannan Hajimahmoodi, Bagher Larijani, Mohammad Mahdavi, Massoud Amanlou   +8 more
doaj   +1 more source

Mushroom tyrosinase: A model system to combine experimental investigation of enzyme‐catalyzed reactions, data handling using R, and enzyme‐inhibitor structural studies

, 2015
The activity of mushroom tyrosinase can be measured by monitoring the conversion of phenolic compounds into quinone derivatives using spectrophotometry.
Will Cresswell, Jacqueline Nairn, Nairn, Jacqueline, Cresswell, Will, Robert Nairn, Nairn, Robert   +5 more
core   +1 more source

Potential of Secondary Metabolites from Acriopsis liliifolia Leaves as a Tyrosinase Inhibitor: Docking Study

The demand of natural chemicals with high effectiveness and low side effects increases plant exploration, including in the cosmetic and pharmaceutical fields.
Apsari, Cintya Nurul, Nuraini, Latifa, Khoeriyah, Ni\u27matul, Wannawijaya, Nashwa Maheswari   +3 more
core   +1 more source

Research Progress in the Application of Tyrosinase Inhibitor

, 2016
酪氨酸酶是一类络合铜离子的金属酶类,广泛存在于动植物、微生物及人体中,是生物体合成黑色素、果蔬褐变的关键酶.酪氨酸酶的异常表现可能会出现黑色素瘤等,黑色素异常生成造成的色素沉着是动物衰老及果蔬褐变的重要表现.综述了酪氨酸酶抑制剂在美容保健、色素型皮肤病的治疗、病虫害防治以及食品保鲜等方面的应用,如:通过直接抑制酪氨酸酶活性以及调控细胞中酪氨酸酶的表达量来有效调控黑色素的生成,从而达到美白及治疗色素紊乱症的作用;抑制果蔬褐变,延长货架期;抑制昆虫蜕皮时的鞣化,达到杀灭农业害虫的目的 ...
陈清西, 胡泳华, 贾玉龙
core  

Elektrode Komposit Zeolit sebagai Biosensor Berbasis Tirosinase

, 2014
Tyrosinase is a copper-containing oxidase, which catalyzes the first 2 steps in mammalian melanogenesis and responsible for enzymatic browning reactions.
Yunita, Maryani
core  

Durio zibethinus rind as tyrosinase inhibitor for skin whitening agents in cosmetic products: RSM, COSMO-RS, PCA and molecular docking studies

, 2020
In this study, Response surface methodology (RSM) and Supercritical fuid extraction (SFE) were used to optimize the extraction of the polyphenols from Durio zibethinus rind. The optimized extraction variables conditions were found at at 5050 psi pressure,
Abdullah, Erna Normaya, Shamsuri, Syamimi Sulfiza, Ahmad, Mohammad Norazmi, Ismail, Sofiyyah   +3 more
core