Results 31 to 40 of about 22,420 (243)

Biology of advanced uveal melanoma and next steps for clinical therapeutics [PDF]

, 2014
Uveal melanoma is the most common intraocular malignancy although it is a rare subset of all melanomas. Uveal melanoma has distinct biology relative to cutaneous melanoma, with widely divergent patient outcomes.
Bastian, BC, Bowcock, AM, Carvajal, RD, Flaherty, KT, Gershenwald, JE, Gutkind, JS, Luke, JJ, McKenna, KC, Patel, PM, Sato, T, Selig, S, Sossman, JA, Streicher, HZ, Sznol, M, Thurin, M, Triozzi, PL, Van Meir, EG, Welch, J   +17 more
core   +1 more source

Tyrosinase Inhibitors from Crude Drugs.

Biological and Pharmaceutical Bulletin, 1994
Various crude drugs were examined for their tyrosinase inhibitory activity. Marked activity was observed in Chouji and Yakuchi extracts and the active substances in these extracts were identified as eugenol and yakuchinone A, respectively. Other vanillyl compounds such as ferulic acid, curcumin and yakuchinone B also had higher activities than eugenol ...
S, Shirota, K, Miyazaki, R, Aiyama, M, Ichioka, T, Yokokura   +4 more
openaire   +3 more sources

UV-A light treatment for controlling enzymatic browning of fresh-cut fruits [PDF]

, 2016
Enzymatic browning is critical in the preservation of the quality and the shelf-life of fresh-cut fruits. Non-thermal technologies such as UV radiation are emerging for controlling polyphenol oxidase (PPO) activity, the main agent responsible for ...
Lante, Anna, Nicoletto, Marino, Tinello, Federica   +2 more
core   +1 more source

A Competitive Inhibitor of Tyrosinase [PDF]

Australian Journal of Biological Sciences, 1951
The kinetics of the activation of catechol by tyrosinase prepared from the potato and the mushroom, and of its inhibition by sodium m-hydroxybenzoate, have been studied. The enzyme-substrate dissociation constants differed markedly between the two enzyme sources (K.
openaire   +2 more sources

Control Strategies in Guanine Biocrystallization

Angewandte Chemie, EarlyView.
Biological guanine crystals produce spectacular photonic phenomena in animals and hold great promise as new, sustainable optical materials. We review how organisms precisely control the structure, morphologies, and resulting optical properties of these crystals using a set of ingenious ‘design’ strategies, including control of pH, template‐directed ...
Shashanka S. Indri, Avital Wagner, Benjamin A. Palmer   +2 more
wiley   +2 more sources

Novel tyrosinase inhibitory peptide with free radical scavenging ability

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Tyrosinase is a key enzyme involved in melanin synthesis. Therefore, various tyrosinase inhibitors have been screened by researchers in recent years. In the present study, we discovered a novel tyrosinase inhibitor, a peptide ECGYF (named EF-5), with ...
Zhiwei Shen, Yujiao Wang, Zhen Guo, Tingyuan Tan, Yi Zhang   +4 more
doaj   +1 more source

Synthesis, In Silico Studies, and Antioxidant and Tyrosinase Inhibitory Potential of 2-(Substituted Phenyl) Thiazolidine-4-Carboxamide Derivatives

Pharmaceuticals, 2023
Heterocyclic nuclei have shown a wide variety of biological activities, highlighting their importance in drug discovery. Derivatives of 2,4-subsituted thiazolidine have a structural similarity with the substrates of tyrosinase enzymes. Hence, they can be
Muhammad Kazim Zargaham, Madiha Ahmed, Nosheen Akhtar, Zaman Ashraf, Mostafa A. Abdel-Maksoud, Mohammed Aufy, Humaira Nadeem   +6 more
doaj   +1 more source

Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour [PDF]

, 2016
The five-subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in
Insall, Robert H., Machesky, Laura M., Spence, Heather J., Strathdee, Douglas, Tyrrell, Benjamin J., Woodham, Emma F.   +5 more
core   +1 more source

Kinetics Investigation on Mushroom Tyrosinase Inhibition of Proso Millet

Journal of Chemistry, 2018
Proso millet (Panicum miliaceum) is rich in nutritive components and is widely used as a human food, feed and forage for animals, and fuel. This study investigated the effect of a proso millet extract on the inhibition of tyrosinase, a key enzyme in ...
Wen-Ying Huang, Hui-Ju Chen, Chia-Ching Lin, Chin-Shuh Chen, Yung-Sheng Lin   +4 more
doaj   +1 more source

Synthesis and Tyrosinase Inhibitory Activity of (E)-5-Benzyl-7- (3-Bromobenzylidene)-3-(3-Bromophenyl)-2-Phenyl-3,3a, 4,5,6,7-Hexahydro-2H-Pyrazolo[4,3-c]Pyridine

Jurnal Kimia Sains dan Aplikasi, 2022
The tyrosinase enzyme plays an essential role in the pigmentation of human skin, fruits, and vegetables. It has been tied with several human skin diseases and post-harvest problems.
Nelly Oscifiani, Noval Herfindo, Rahayu Rahayu, Neni Frimayanti, Adel Zamri   +4 more
doaj   +1 more source