Results 101 to 110 of about 4,897 (216)
Sex and life experience shape locus coeruleus pretangle tau pathology
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract INTRODUCTION Alzheimer's disease features early a pathology in the locus coeruleus (LC), yet how sex and life experience shape LC vulnerability remains poorly understood. METHODS We expressed pseudophosphorylated human tau (htauE14) in LC neurons of TH‐Cre rats and exposed both sexes to early‐ or late‐life enrichment or stress.
Zia Hasan +10 more
wiley +1 more source
Consequences of a mobile genetic element integrated at secondary locations [PDF]
, 2013 Thesis (Ph. D.)--Massachusetts Institute of Technology, Microbiology Graduate Program, 2013.Cataloged from PDF version of thesis.Includes bibliographical references (pages 91-96).Integrative and conjugative elements (ICEs) are widespread mobile genetic ...
Menard, Kayla L. (Kayla Lynne)
core
Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn [PDF]
, 2017 The spinal dorsal horn receives input from primary afferent axons, which terminate in a modality-specific fashion in different laminae. The incoming somatosensory information is processed through complex synaptic circuits involving excitatory and ...
Todd, Andrew J.
core +1 more source
HemaSphere, Volume 10, Issue 3, March 2026.Abstract TP53 mutations are found in over 50% of tumor types, including myeloproliferative neoplasms (MPNs). MPNs are characterized by a chronic phase, which may progress to secondary acute myeloid leukemia (sAML). Here, we discuss the physiological functions of p53 in hematopoiesis and its deregulation in MPNs.
Suzana da Silva‐Benedito +6 more
wiley +1 more source
A Model of DNA Knotting and Linking [PDF]
, 2007 We present a model of how DNA knots and links are formed as a result of a single recombination event, or multiple rounds of (processive) recombination events, starting with an unknotted, unlinked, or a (2,m)-torus knot or link substrate.
Buck, Dorothy, Flapan, Erica
core +3 more sources
Mechanistic modeling of a rewritable recombinase addressable data module [PDF]
, 2016 Many of the most important applications predicted to arise from Synthetic Biology will require engineered cellular memory with the capability to store data in a rewritable and reversible manner upon induction by transient stimuli.
Bates, Declan +5 more
core +2 more sources
CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling
Med Research, Volume 2, Issue 1, Page 106-129, March 2026.CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li +8 more
wiley +1 more source
Frontiers in Microbiology, 2018 Members of the genus Acinetobacter possess distinct plasmid types which provide effective platforms for the acquisition, evolution, and dissemination of antimicrobial resistance structures.
María M. Cameranesi +4 more
doaj +1 more source
Mining ice in genomes: comparative genomics of integrative elements in prokaryotic genomes [PDF]
, 2010 Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2010Elementos integrativos e conjugativos (ICEs) são um grupo muito diverso de elementos genéticos móveis, que se caracterizam por partilharem ...
Quintais, Leonor Maria dos Santos Silva Tomé, 1986-
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The chondro-osseous continuum: is it possible to unlock the potential assigned within? [PDF]
, 2018 Endochondral ossification (EO), by which long bones of the axial skeleton form, is a tightly regulated process involving chondrocyte maturation with successive stages of proliferation, maturation, and hypertrophy, accompanied by cartilage matrix ...
Adams +79 more
core +3 more sources