Results 11 to 20 of about 98,327 (230)
The ubiquitin-proteasome system is required for African swine fever replication. [PDF]
PLoS ONE, 2017 Several viruses manipulate the ubiquitin-proteasome system (UPS) to initiate a productive infection. Determined viral proteins are able to change the host's ubiquitin machinery and some viruses even encode their own ubiquitinating or deubiquitinating ...
Lucía Barrado-Gil +4 more
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The ubiquitin-proteasome system
Journal of Biosciences, 2006 The 2004 Nobel Prize in chemistry for the discovery of protein ubiquitination has led to the recognition of cellular proteolysis as a central area of research in biology. Eukaryotic proteins targeted for degradation by this pathway are first 'tagged' by multimers of a protein known as ubiquitin and are later proteolyzed by a giant enzyme known as the ...
Nandi, Dipankar +3 more
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Denervation-Induced Activation of the Ubiquitin-Proteasome System Reduces Skeletal Muscle Quantity Not Quality. [PDF]
PLoS ONE, 2016 It is well known that the ubiquitin-proteasome system is activated in response to skeletal muscle wasting and functions to degrade contractile proteins. The loss of these proteins inevitably reduces skeletal muscle size (i.e., quantity).
Cory W Baumann +2 more
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PLoS ONE, 2022 The ubiquitin/proteasome system controls the stability of Runx2 and JunB, proteins essential for differentiation of mesenchymal progenitor/stem cells (MPCs) to osteoblasts.
Hengwei Zhang +6 more
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Journal of Inflammation, 2011 Hypercatabolism is common under septic conditions. Skeletal muscle is the main target organ for hypercatabolism, and this phenomenon is a vital factor in the deterioration of recovery in septic patients.
Gao Tao +8 more
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Niclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibition. [PDF]
PLoS ONE, 2010 Protein aggregation is a hallmark of many neurodegenerative diseases and has been linked to the failure to degrade misfolded and damaged proteins. In the cell, aberrant proteins are degraded by the ubiquitin proteasome system that mainly targets short ...
Esther Gies +9 more
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mBio, 2014 Streptococcus pneumoniae (pneumococcus) is a Gram-positive bacterium that causes serious invasive diseases, such as pneumonia, bacteremia, and meningitis, with high morbidity and mortality throughout the world.
Federico Iovino +2 more
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Stressing the ubiquitin-proteasome system [PDF]
Cardiovascular Research, 2009 Unfolded and misfolded proteins are inherently toxic to cells and have to be quickly and efficiently eliminated before they intoxicate the intracellular environment. This is of particular importance during proteotoxic stress when, as a consequence of intrinsic or extrinsic factors, the levels of misfolded proteins are transiently or persistently ...
Nico P, Dantuma, Kristina, Lindsten
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F1000Research, 2015 The ubiquitin-proteasome system is the major degradation pathway for short-lived proteins in eukaryotic cells. Targets of the ubiquitin-proteasome-system are proteins regulating a broad range of cellular processes including cell cycle progression, gene ...
Maisha Chowdhury, Cordula Enenkel
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The Ubiquitin-Proteasome System in Neurodegeneration [PDF]
Antioxidants & Redox Signaling, 2014 Impairment of the ubiquitin-proteasome system (UPS) has been implicated in the pathogenesis of a wide variety of neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's diseases. The most significant risk factor for the development of these disorders is aging, which is associated with a progressive decline in UPS activity and ...
Chris McKinnon, Sarah J. Tabrizi
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