Results 21 to 30 of about 98,327 (230)
Intracellular Dynamics of the Ubiquitin-Proteasome-System [version 2; referees: 3 approved]
F1000Research, 2015 The ubiquitin-proteasome system is the major degradation pathway for short-lived proteins in eukaryotic cells. Targets of the ubiquitin-proteasome-system are proteins regulating a broad range of cellular processes including cell cycle progression, gene ...
Maisha Chowdhury, Cordula Enenkel
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Journal of Cachexia, Sarcopenia and Muscle, 2020 Background Statins are the cornerstone of pharmacotherapy for atherosclerotic cardiovascular disease. While these drugs are generally safe, treatment adherence is not optimal in a considerable proportion of patients because of the adverse effects on ...
Amirhossein Sahebkar +9 more
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Control of mitochondrial biogenesis and function by the ubiquitin–proteasome system [PDF]
Open Biology, 2017 Mitochondria are pivotal organelles in eukaryotic cells. The complex proteome of mitochondria comprises proteins that are encoded by nuclear and mitochondrial genomes. The biogenesis of mitochondrial proteins requires their transport in an unfolded state
Piotr Bragoszewski +2 more
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Poxvirus Exploitation of the Ubiquitin-Proteasome System
Viruses, 2010 Ubiquitination plays a critical role in many cellular processes. A growing number of viruses have evolved strategies to exploit the ubiquitin-proteasome system, including members of the Poxviridae family. Members of the poxvirus family have recently been
Alastair Teale +5 more
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Site-Specific Proteasome Inhibitors
Biomolecules, 2021 Proteasome is a multi-subunit protein degradation machine, which plays a key role in the maintenance of protein homeostasis and, through degradation of regulatory proteins, in the regulation of numerous cell functions. Proteasome inhibitors are essential
Alexei F. Kisselev
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The Ubiquitin–Proteasome System in Immune Cells
Biomolecules, 2021 The ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal protein degradation system. Thanks to its unique capacity of eliminating old, damaged, misfolded, and/or regulatory proteins in a highly specific manner, the UPS is ...
Gonca Çetin +4 more
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International Journal of Inflammation, 2023 Different protein degradation pathways exist in cells. However, the bulk of cellular proteins are degraded by the ubiquitin-proteasome system (UPS), which is one of these pathways.
Fikadu Seyoum Tola
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An extract of Artemisia dracunculus L. inhibits ubiquitin-proteasome activity and preserves skeletal muscle mass in a murine model of diabetes. [PDF]
PLoS ONE, 2013 Impaired insulin signaling is a key feature of type 2 diabetes and is associated with increased ubiquitin-proteasome-dependent protein degradation in skeletal muscle. An extract of Artemisia dracunculus L.
Heather Kirk-Ballard +8 more
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Dual Function of USP14 Deubiquitinase in Cellular Proteasomal Activity and Autophagic Flux
Cell Reports, 2018 Summary: The ubiquitin-proteasome system and the autophagy-lysosome system are two major intracellular proteolytic pathways in eukaryotes. Although several biochemical mechanisms underlying the crosstalk between them have been suggested, little is known ...
Eunkyoung Kim +9 more
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Characterization of the ubiquitylating components of the human malaria parasite's protein degradation pathway. [PDF]
PLoS ONE, 2012 Ubiquitin-dependent protein degradation within malarial parasites is a burgeoning field of interest due to several encouraging reports of proteasome inhibitors that were able to confer antimalarial activity. Despite the growing interest in the Plasmodium
Duk-Won D Chung +4 more
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