Results 11 to 20 of about 278,733 (404)
Cell & Bioscience, 2022 Ubiquitination is a versatile post-translational modification (PTM), which regulates diverse fundamental features of protein substrates, including stability, activity, and localization.
Mingwei Sun, Xiaofei Zhang
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Cellular functions and molecular mechanisms of non-lysine ubiquitination [PDF]
Open Biology, 2019 Protein ubiquitination is of great cellular importance through its central role in processes such as degradation, DNA repair, endocytosis and inflammation.
Amie J. McClellan +2 more
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Regulation of reactive oxygen species during plant immunity through phosphorylation and ubiquitination of RBOHD. [PDF]
Nature Communications, 2020 Production of reactive oxygen species (ROS) is critical for successful activation of immune responses against pathogen infection. The plant NADPH oxidase RBOHD is a primary player in ROS production during innate immunity. However, how RBOHD is negatively
Castro, Bardo +8 more
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PLoS ONE, 2021 Signaling by the Rho GTPase Rac1 is key to the regulation of cytoskeletal dynamics, cell spreading and adhesion. It is widely accepted that the inactive form of Rac1 is bound by Rho GDI, which prevents Rac1 activation and Rac1-effector interactions.
Jisca Majolée +3 more
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Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum
Nature, 2023 The endoplasmic reticulum (ER) undergoes continuous remodelling via a selective autophagy pathway, known as ER-phagy^ 1 . ER-phagy receptors have a central role in this process^ 2 , but the regulatory mechanism remains largely unknown.
Alexis González +18 more
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Ubiquitination in the regulation of inflammatory cell death and cancer
Cell Death and Differentiation, 2021 The ubiquitin system is complex, multifaceted, and is crucial for the modulation of a vast number of cellular processes. Ubiquitination is tightly regulated at different levels by a range of enzymes including E1s, E2s, and E3s, and an array of DUBs.
Peter E Cockram +5 more
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Journal of Hematology & Oncology, 2021 Background TNBC is the most aggressive breast cancer with higher recurrence and mortality rate than other types of breast cancer. There is an urgent need for identification of therapeutic agents with unique mode of action for overcoming current ...
Yahui Ding +8 more
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Structural propensities of human ubiquitination sites: accessibility, centrality and local conformation. [PDF]
PLoS ONE, 2013 The existence and function of most proteins in the human proteome are regulated by the ubiquitination process. To date, tens of thousands human ubiquitination sites have been identified from high-throughput proteomic studies.
Yuan Zhou +3 more
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The role of ubiquitination and deubiquitination in tumor invasion and metastasis
International Journal on Biological Sciences, 2022 Ubiquitination is vital for multiple cellular processes via dynamic modulation of proteins related to cell growth, proliferation, and survival. Of the ubiquitination system components, E3 ubiquitin ligases and deubiquitinases have the most prominent ...
Shuang Han +8 more
semanticscholar +1 more source
Emerging Roles of Non-proteolytic Ubiquitination in Tumorigenesis
Frontiers in Cell and Developmental Biology, 2022 Ubiquitination is a critical type of protein post-translational modification playing an essential role in many cellular processes. To date, more than eight types of ubiquitination exist, all of which are involved in distinct cellular processes based on ...
Xiu Yin +8 more
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