Results 11 to 20 of about 165,549 (296)
Insights into the protein ubiquitinome in the host‒pathogen interplay during Mycobacterium tuberculosis infection [PDF]
Frontiers in Molecular BiosciencesMycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis capable of manipulating and circumventing the host’s immune system to establish infection.
Qishun Feng +6 more
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PLoS ONE, 2021 Signaling by the Rho GTPase Rac1 is key to the regulation of cytoskeletal dynamics, cell spreading and adhesion. It is widely accepted that the inactive form of Rac1 is bound by Rho GDI, which prevents Rac1 activation and Rac1-effector interactions.
Jisca Majolée +3 more
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Structural propensities of human ubiquitination sites: accessibility, centrality and local conformation. [PDF]
PLoS ONE, 2013 The existence and function of most proteins in the human proteome are regulated by the ubiquitination process. To date, tens of thousands human ubiquitination sites have been identified from high-throughput proteomic studies.
Yuan Zhou +3 more
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To Be or Not to Be...Ubiquitinated? [PDF]
Cell Cycle, 2004 Levels of p21, a cyclin-dependent kinase (CDK) inhibitor, are controlled in part at the post-translational level by protein degradation. Although the signaling pathways leading to p21 degradation have not yet been fully elucidated, it is evident that p21 ubiquitination is an essential factor in its degradation.
Michele Pagano, Joanna Bloom
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Cell & Bioscience, 2022 Ubiquitination is a versatile post-translational modification (PTM), which regulates diverse fundamental features of protein substrates, including stability, activity, and localization.
Mingwei Sun, Xiaofei Zhang
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Emerging Roles of Non-proteolytic Ubiquitination in Tumorigenesis
Frontiers in Cell and Developmental Biology, 2022 Ubiquitination is a critical type of protein post-translational modification playing an essential role in many cellular processes. To date, more than eight types of ubiquitination exist, all of which are involved in distinct cellular processes based on ...
Xiu Yin +8 more
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Cellular functions and molecular mechanisms of non-lysine ubiquitination [PDF]
Open Biology, 2019 Protein ubiquitination is of great cellular importance through its central role in processes such as degradation, DNA repair, endocytosis and inflammation.
Amie J. McClellan +2 more
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Cracking the Ubiquitin Code: The Ubiquitin Toolbox [PDF]
Current Issues in Molecular Biology, 2019 Ubiquitination, a post-translational modification, regulates a vast array of fundamental biological processes with dysregulation of the dedicated enzymes giving rise to pathologies such as cancer and neurodegenerative diseases. Assembly and its ensuing removal of this post-translational modification, determining a large variety of biological functions,
Mulder, M.P.C., Witting, K.F., Ovaa, H.
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Role of K63-linked ubiquitination in cancer
Cell Death Discovery, 2022 Ubiquitination is a critical type of post-translational modifications, of which K63-linked ubiquitination regulates interaction, translocation, and activation of proteins.
Liangzi Cao +4 more
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Tau Ubiquitination in Alzheimer's Disease
Frontiers in Neurology, 2022 Paired helical filaments (PHFs) from the Alzheimer's disease (AD) brain are highly ubiquitinated and ubiquitination likely plays a vital role in tau filament formation.
Longfei Li +8 more
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