Cancer Communications, 2021 Background Tumor metastasis is a major factor for poor prognosis of hepatocellular carcinoma (HCC), but the relationship between ubiquitination and metastasis need to be studied more systematically.
Feiyang Ji +8 more
doaj +2 more sources
Frontiers in Microbiology, 2022 Herpes simplex virus 1 (HSV-1) can productively infect multiple cell types and establish latent infection in neurons. Infected cell protein 0 (ICP0) is an HSV-1 E3 ubiquitin ligase crucial for productive infection and reactivation from latency.
Fujun Hou +14 more
doaj +3 more sources
Ubiquitous ubiquitin : the K63 ubiquitinome [PDF]
The Plant Cell, 2020 Polyubiquitination, the sequential attachment of the small 8 kDa globular protein ubiquitin (Ub) to target proteins, represents a major posttranslational modification that ultimately determines the substrate’s cellular fate. Ub conjugation is an extremely versatile form of protein regulation,
Breeze, Emily
core +4 more sources
A ubiquitinome analysis to study the functional roles of the proteasome associated deubiquitinating enzymes USP14 and UCH37 [PDF]
Journal of Proteomics, 2022 The removal of (poly)ubiquitin chains at the proteasome is a key step in the protein degradation pathway that determines which proteins are degraded and ultimately decides cell fate.
Bezstarosti, Karel +2 more
core +4 more sources
Spatial Mechano‐Signaling Regulation of GTPases through Non‐Degradative Ubiquitination
Advanced Science, 2023 Blood flow produces shear stress exerted on the endothelial layer of the vessels. Spatial characterization of the endothelial proteome is required to uncover the mechanisms of endothelial activation by shear stress, as blood flow varies in the ...
Raj N. Sewduth +10 more
doaj +2 more sources
Aspirin inhibits proteasomal degradation and promotes α-synuclein aggregate clearance through K63 ubiquitination [PDF]
Nature CommunicationsAspirin is a potent lysine acetylation inducer, but its impact on lysine ubiquitination and ubiquitination-directed protein degradation is unclear. Herein, we develop the reversed-pulsed-SILAC strategy to systematically profile protein degradome in ...
Jing Gao +14 more
doaj +2 more sources
Combined multiomics analysis reveals the mechanism of CENPF overexpression-mediated immune dysfunction in diffuse large B-cell lymphoma in vitro [PDF]
Frontiers in Genetics, 2022 Diffuse large B-cell lymphoma (DLBCL) is one of the most common aggressive B-cell lymphomas with significant heterogeneity. More than half of patients are cured, but 40%–45% still face relapse or develop drug resistance, and the mechanism is not yet ...
Dan Yang +9 more
doaj +2 more sources
The Lolal-dpp axis mediates the regulation of host reproduction by gut symbionts in insects [PDF]
Nature CommunicationsGut commensal microbiota can play an integral role in shaping insect reproduction, but the underlying mechanisms remain largely unexplored. Here, we report that gut bacteria promote host reproduction in the oriental fruit fly Bactrocera dorsalis by ...
Jiao Qiao +6 more
doaj +2 more sources
A computational tool to infer enzyme activity using post-translational modification profiling data [PDF]
Communications BiologyEnzymes play a pivotal role in orchestrating complex cellular responses to external stimuli and environmental changes through signal transduction pathways.
Dehui Kong +9 more
doaj +2 more sources
Proteogenomic reprogramming to a functional human blastomere-like stem cell state via a PARP-DUX4 regulatory axis [PDF]
Cell ReportsSummary: Here, we show that conventional human pluripotent stem cells cultured with non-specific tankyrase-PARP1-inhibited conditions underwent proteogenomic reprogramming to functional blastomere-like tankyrase/PARP inhibitor-regulated naive stem cells (
Ludovic Zimmerlin +11 more
doaj +2 more sources