Results 31 to 40 of about 851 (145)

USP5 Promotes Ripretinib Resistance in Gastrointestinal Stromal Tumors by MDH2 Deubiquition

Advanced Science
Ripretinib, a broad‐spectrum inhibitor of the KIT and PDGFRA receptor tyrosine kinases, is designated as a fourth‐line treatment for gastrointestinal stromal tumor (GIST). It is tailored for patients resistant to imatinib, sunitinib, and regorafenib.
Haoyu Sun, Zhiwei Cui, Chao Li, Zhishuang Gao, Jun Xu, Yibo Bian, Tianhao Gu, Jianan Zhang, Tengyun Li, Qianzheng Zhou, Dinghua Yang, Zhongyuan He, Bowen Li, Fengyuan Li, Zekuan Xu, Hao Xu   +15 more
doaj   +2 more sources

Use of a High-Affinity Ubiquitin-Binding Domain to Detect and Purify Ubiquitinated Substrates and Their Interacting Proteins [PDF]

Bio-Protocol
OtUBD is a high-affinity ubiquitin-binding domain (UBD) derived from a large protein produced by the microorganism Orientia tsutsugamushi. The following protocol describes a step-by-step process for the enrichment of ubiquitinated proteins from baker'
Nitu Saha, Mengwen Zhang, Mark Hochstrasser   +2 more
doaj   +2 more sources

Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells

Nature Communications, 2022
Here the authors combine multi-omics approaches to uncover a role for ubiquitination and the ubiquitin ligase NEDD4 in targeting the actin binding protein Profilin 1 to regulate actin polymerisation in neural crest cells.
Iman Lohraseb, Peter McCarthy, Genevieve Secker, Ceilidh Marchant, Jianmin Wu, Naveid Ali, Sharad Kumar, Roger J. Daly, Natasha L. Harvey, Hiroshi Kawabe, Oded Kleifeld, Sophie Wiszniak, Quenten Schwarz   +12 more
doaj   +6 more sources

Recent advances in proteomic workflows to interrogate the SUMOylome in plants. [PDF]

New Phytologist, Volume 247, Issue 1, Page 90-96, July 2025.
Protein posttranslational modifications (PTMs) are vital for regulating protein functions. SUMOylation, a PTM essential for plant survival, involves attaching a Small Ubiquitin-like MOdifier (SUMO) to lysine residues of target proteins.
Kishor D. Ingole, Elizaveta Alekseeva, Kathryn S. Lilley, Ari Sadanandom   +3 more
core   +3 more sources

System-wide identification of novel de-ubiquitination targets for USP10 in gastric cancer metastasis through multi-omics screening [PDF]

BMC Cancer
Objective Ubiquitin-specific peptidase 10 (USP10), a typical de-ubiquitinase, has been found to play a double-edged role in human cancers. Previously, we reported that the expression of USP10 was negatively correlated with the depth of gastric wall ...
Zhi Zeng, Yina Li, Heng Zhou, Mingyang Li, Juan Ye, Dan Li, Yuxi Zhu, Yonggang Zhang, Xu Zhang, Yunchao Deng, Juan Li, Lijuan Gu, Jie Wu   +12 more
doaj   +2 more sources

Integrative Omics Reveals Glutamine Catabolism-Driven Apoptotic Suppression in Monocytes upon Mechanical Unloading. [PDF]

Adv Sci (Weinh)
This research integrated multi‐omics analysis of bone tissue from HLU and control mice revealed that mechanical unloading suppresses intrinsic apoptosis and augments glutamine (Gln) catabolism in osteoclast lineage cells. The findings highlight pivotal roles for SLC1A5‐mediated Gln metabolism and XIAP/Diablo axis‐mediated apoptosis suppression.
Ding Y, Tong F, Liu M, Yang P, Zeng J, Wei Y, Li C, Li D, Chang C, Zhang Y, Yi S, Hu F, Shu W, Zhang L, Cui CP.   +14 more
europepmc   +2 more sources

Root Membrane Ubiquitinome under Short-Term Osmotic Stress [PDF]

International Journal of Molecular Sciences, 2021
Osmotic stress can be detrimental to plants, whose survival relies heavily on proteomic plasticity. Protein ubiquitination is a central post-translational modification in osmotic-mediated stress. In this study, we used the K-Ɛ-GG antibody enrichment method integrated with high-resolution mass spectrometry to compile a list of 719 ubiquitinated lysine ...
Berger, Nathalie, Demolombe, Vincent, Hem, Sonia, Rofidal, Valérie, Steinmann, Laura, Krouk, Gabriel, Crabos, Amandine, Nacry, Philippe, Verdoucq, Lionel, Santoni, Veronique   +9 more
openaire   +5 more sources

Active protein ubiquitination regulates xylem vessel functionality. [PDF]

Plant Cell
Phookaew P, Ma Y, Suzuki T, Stolze SC, Harzen A, Sano R, Nakagami H, Demura T, Ohtani M.   +8 more
europepmc   +3 more sources

Global ubiquitinome analysis reveals the role of E3 ubiquitin ligase FaBRIZ in strawberry fruit ripening. [PDF]

J Exp Bot, 2023
AbstractUbiquitination is an important post-translational modification that mediates protein degradation in eukaryotic cells, participating in multiple biological processes. However, the profiling of protein ubiquitination and the function of this crucial modification in fruit ripening remain largely unknown. In this study, we found that suppression of
Wang Y, Kong L, Wang W, Qin G.
europepmc   +3 more sources

Unveiling ubiquitinome rearrangements induced by Salmonella infection [PDF]

Autophagy, 2016
Ubiquitination plays a critical role in the activation of host immune responses to infection and serves as a signal for pathogen delivery to phagophores along the xenophagy pathway. We recently performed systematic ubiquitination site profiling of epithelial cells infected with Salmonella Typhimurium.
Bionda, Tihana, Behrends, Christian
openaire   +4 more sources