Extensive differential protein phosphorylation as intraerythrocytic Plasmodium falciparumschizonts develop into extracellular invasive merozoites [PDF]
, 2015 Pathology of the most lethal form of malaria is caused by Plasmodium falciparum asexual blood stages and initiated by merozoite invasion of erythrocytes.
Grainger, Munira +4 more
core +1 more source
Detection of the Ubiquitinome in Cells Undergoing Oncogene-Induced Senescence [PDF]
, 2016 Senescent cells exhibit dramatic changes in protein post-translational modifications. Here, we describe a method, stable isotope labeling with amino acids in cell culture (SILAC) coupled to liquid chromatography tandem mass spectrometry (LC-MS/MS), to identify changes in the ubiquitinome in cells that have undergone oncogene-induced senescence.
Hengrui, Zhu +4 more
openaire +2 more sources
Targeted interplay between bacterial pathogens and host autophagy [PDF]
, 2019 Due to the critical role played by autophagy in pathogen clearance, pathogens have developed diverse strategies to subvert autophagy. Despite previous key findings of bacteria-autophagy interplay, a systems level insight into selective targeting by the ...
Ari, Eszter +10 more
core +3 more sources
The global proteome and ubiquitinome of bacterial and viral co-infected bronchial epithelial cells
Journal of Proteomics, 2022 Viral infections facilitate bacterial trafficking to the lower respiratory tract resulting in bacterial-viral co-infections. Bacterial dissemination to the lower respiratory tract is enhanced by influenza A virus induced epithelial cell damage and dysregulation of immune responses.
Thomas, Sura +5 more
openaire +2 more sources
Frontiers in Oncology, 2021 Serpinc1 is a serine protease inhibitor in the coagulation cascade, but its role in tumor biology remains obscure. Here, we report an unexpected role of serpinc1 in suppression of hepatocellular carcinoma (HCC).
Dacai Xu +7 more
doaj +1 more source
Essential role of proteasomes in maintaining self-renewal in neural progenitor cells [PDF]
, 2016 Protein turnover and homeostasis are regulated by the proteasomal system, which is critical for cell function and viability. Pluripotency of stem cells also relies on normal proteasomal activity that mitigates senescent phenotypes induced by intensive ...
A Kitamura +46 more
core +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Epithelial cells are an important line of defense within the lung. Disruption of the epithelial barrier by pathogens enables the systemic dissemination of bacteria or viruses within the host leading to severe diseases with fatal outcomes.
Thomas Sura +6 more
doaj +1 more source
Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame. [PDF]
, 2016 The endoplasmic reticulum (ER)-anchored hepatic cytochromes P450 (P450s) are enzymes that metabolize endo- and xenobiotics i.e. drugs, carcinogens, toxins, natural and chemical products.
Correia, Maria Almira +4 more
core +1 more source
The mechano-ubiquitinome of articular cartilage: differential ubiquitination and activation of a group of ER-associated DUBs and ER stress regulators [PDF]
, 2022 Understanding how connective tissue cells respond to mechanical stimulation is important to human health and disease processes in musculoskeletal diseases.
Ismail, H.M. +4 more
core +2 more sources
Frontiers in Endocrinology, 2022 Abnormal ubiquitination is extensively associated with cancers. To investigate human lung cancer ubiquitination and its potential functions, quantitative ubiquitinomics was carried out between human lung squamous cell carcinoma (LSCC) and control tissues, which characterized a total of 627 ubiquitin-modified proteins (UPs) and 1209 ubiquitinated lysine
Xianquan Zhan +17 more
openaire +3 more sources