Results 71 to 80 of about 851 (145)
Multiomics integration-based molecular characterizations of COVID-19 [PDF]
, 2022 The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapidly became a global health challenge, leading to unprecedented social and economic consequences.
Chen, Lu +6 more
core +1 more source
Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology [PDF]
, 2020 SUMMARYProtein ubiquitination is involved in virtually all cellular processes. Enrichment strategies employing antibodies targeting ubiquitin-derived diGly remnants combined with mass spectrometry (MS) have enabled investigations of ubiquitin signaling at a large scale.
Fynn M. Hansen +7 more
openaire +1 more source
The deubiquitylase TRABID coordinates sex-specific neurodegeneration in drosophila melanogaster [PDF]
, 2023 Ubiquitin-related post translation modification (PTM) plays an important role in cellular signalling. TRABID is a deubiquitylase that preferentially hydrolyses Lys29 and 33 ubiquitin chains and is known to affect inflammation and consequently ...
Xia, Jingnu
core +2 more sources
Site-specific K63 ubiquitinomics reveals post-initiation regulation of ribosomes under oxidative stress [PDF]
, 2018 AbstractDuring oxidative stress, K63-linked polyubiquitin chains accumulate in the cell and modify a variety of proteins including ribosomes. Knowledge of the precise sites of K63 ubiquitin is key to understanding its function during the response to stress.
Back, Songhee +2 more
openaire +2 more sources
Frontiers in Endocrinology, 2022 Ubiquitination is reported to be a critical biological event on ACTH secretion in corticotroph adenomas. However, the effect of ubiquitylation on ACTH secretion in silent corticotroph adenomas (SCAs) remains unclear. The aim of our study was to explore the mechanism of decreased secretion of ACTH in SCAs with ubiquitinomics.
Sida Zhao +7 more
openaire +3 more sources
AbstractTargeted protein degradation (TPD) has emerged as a highly promising therapeutic strategy for a wide range of diseases, including cancer and neurodegenerative disorders. The ubiquitin-proteasome system, which is responsible for protein degradation, plays a critical role in this process.
Sathe G +11 more
europepmc +2 more sources
Root ubiquitinome under osmotic stress
, 2021 Osmotic stress is detrimental for the plant which survival relies heavily on proteomic plasticity. Protein ubiquitination is a central post-translational modification in osmotic mediated stress. Plants use the ubiquitin proteasome system to modulate protein contents required to respond to and tolerate adverse growth conditions and a role for ubiquitin ...
Berger, Nathalie +7 more
openaire +3 more sources
Advanced Science, EarlyView.G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li +8 more
wiley +1 more source
Journal of Inflammation Research, 2022 Jinjin Tong,1,* Xintong Ji,1,* Hua Zhang,1 Benhai Xiong,2 Defeng Cui,3 Linshu Jiang1 1Beijing Key Laboratory for Dairy Cow Nutrition, Beijing University of Agriculture, Beijing, People’s Republic of China; 2State Key Laboratory of Animal ...
Tong J +5 more
doaj
Epigenetic regulation of mycorrhizal symbioses: from plastic responses to transgenerational legacies
New Phytologist, EarlyView.Summary Mycorrhizal symbioses represent one of the most widespread and ecologically significant plant–microbe interactions, shaping plant nutrition, stress resilience, and ecosystem functioning. Beyond their role in nutrient exchange and systemic defense, growing evidence suggests that these symbioses also influence plant plasticity within and across ...
Gerson Beltrán‐Torres +9 more
wiley +1 more source