Results 21 to 30 of about 7,973 (164)
PLoS ONE, 2021 Previous studies have revealed that gypenosides produced from Gynostemma pentaphyllum (Thunb.) Makino are mainly dammarane-type triterpenoid saponins with diverse structures and important biological activities, but the mechanism of diversity for ...
Yangmei Zhang +8 more
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Analysis of the UDP-glucuronosyltransferase gene in Portuguese patients with a clinical diagnosis of Gilbert and Crigler–Najjar syndromes [PDF]
, 2006 We describe the molecular study in a cohort of 120 Portuguese patients with the clinical diagnosis of Gilbert syndrome and in one with the diagnosis of Crigler–Najjar syndrome type II, as well as a prenatal diagnosis of Crigler–Najjar syndrome type I ...
Barbot, José +11 more
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Effect of UDP‐glucuronosyltransferase 1A1 activity on risk for developing Gilbert's syndrome
Kaohsiung Journal of Medical Sciences, 2019 Variations at the six nucleotides −3279 (T > G), −53 (A[TA]6TAA > A[TA]7TAA), 211 (G > A), 686 (C > A), 1091 (C > T), and 1456 (T > G) in the UDP‐glucuronosyltransferase 1A1 (UGT1A1) gene were determined in 178 Taiwanese patients with Gilbert's syndrome ...
May‐Jen Huang +5 more
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Molecules, 2012 Gossypol, the polyphenolic constituent isolated from cottonseeds, has been used as a male antifertility drug for a long time, and has been demonstrated to exhibit excellent anti-tumor activity towards multiple cancer types.
Liang Wang +9 more
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Performance of in silico tools for the evaluation of UGT1A1 missense variants [PDF]
, 2015 Variations in the gene encoding uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) are particularly important because they have been associated with hyperbilirubinemia in Gilbert’s and Crigler–Najjar syndromes as well as with changes in drug ...
Bronze-da-Rocha, Elsa +3 more
core +1 more source
Age-dependent Hepatic UDP-glucuronosyltransferase Gene Expression and Activity in Children
Frontiers in Pharmacology, 2016 UDP-glucuronosyltransferases (UGTs) are important phase II drug metabolism enzymes. The aim of this study was to explore the relationship between age and changes in mRNA expression and activity of major human hepatic UGTs, as well as to understand the ...
Elizabeth Neumann +6 more
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Hematologically important mutations: bilirubin UDP-glucuronosyltransferase gene mutations in Gilbert and Crigler-Najjar syndromes. [PDF]
, 2005 Gilbert and Crigler-Najjar syndromes are familial unconjugated hyperbilirubinemias caused by genetic lesions involving a single complex locus encoding for bilirubin UDP-glucuronosyltransferase (UGT1A1) gene.
Costa, Elísio
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Cell Transplantation, 2010 The first indication of hepatocyte transplantation is inborn liver-based metabolic disorders. Among these, urea cycle disorders leading to the impairment to detoxify ammonia and Crigler-Najjar Syndrome type I, a deficiency in the hepatic UDP ...
A. Bonora-Centelles +6 more
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Pharmaceutics, 2017 Uridine diphosphate-glucuronosyltransferases (UGTs) are phase 2 conjugation enzymes mainly located in the endoplasmic reticulum (ER) of the liver and many other tissues, and can be recovered in artificial ER membrane preparations (microsomes).
Yuejian Liu, Michael W. H. Coughtrie
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Inhibitory Effect of Sauchinone on UDP-Glucuronosyltransferase (UGT) 2B7 Activity
Molecules, 2018 Herb–drug interaction (HDI) limits clinical application of herbs and drugs, and inhibition of herbs towards uridine diphosphate (UDP)-glucuronosyltransferases (UGTs) has gained attention as one of the important reasons to cause HDIs.
Byoung Hoon You +2 more
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