Results 21 to 30 of about 57,370 (289)

UGT84F9 is the major flavonoid UDP-glucuronosyltransferase in Medicago truncatula.

Plant Physiology, 2021
Mammalian phase II metabolism of dietary plant flavonoid compounds generally involves substitution with glucuronic acid. In contrast, flavonoids mainly exist as glucose conjugates in plants, and few plant UDP-glucuronosyltransferase enzymes have been ...
Olubu A. Adiji, Maite L. Docampo-Palacios, Anislay Alvarez‐Hernandez, G. Pasinetti, Xiaoqiang Wang, R. Dixon   +5 more
semanticscholar   +1 more source

Pharmacokinetics and Pharmacogenetics of Dabigatran

Рациональная фармакотерапия в кардиологии, 2021
Dabigatran etexilate is a prodrug of dabigatran, a oral direct inhibitor of thrombin. Pharmacokinetics of dabigatran etexilate doesn’t have the disadvantages of vitamin K antagonists.
A. V. Savinova, V. S. Dobrodeeva, M. M. Petrova, R. F. Nasyrova, N. A. Shnayder   +4 more
doaj   +1 more source

Population genetic research of the mutation in ugt1a1 gene associated with reduced activity of liver UDP-glucuronosyltransferase A1

Фундаментальная и клиническая медицина, 2020
Aim. To explore allele and genotype frequencies of the rs8175347 polymorphism within the UGT1A1 gene in Kemerovo Region. Materials and Methods. The study sample included 64 male and 68 female inhabitants of the Kemerovo Region.
A. N. Volkov
doaj   +1 more source

Piscine UDP-glucuronosyltransferase 1B [PDF]

Aquatic Toxicology, 2007
Glucuronidation is an important detoxification pathway for organic pollutants in fish. We report here the isolation and characterisation of UDP-glucuronosyltransferases (UGT) genes from the closely related marine flatfish, plaice (Pleuronectes platessa) and flounder (Platichthys flesus).
Leaver, Michael, Wright, Joy, Hodgson, Paul, Boukouvala, Evridiki, George, Stephen   +4 more
openaire   +3 more sources

UDP-glucuronosyltransferase is involved in susceptibility of Chironomus kiiensis Tokunaga, 1936 (Diptera: Chironomidae) to insecticides

Ecotoxicology and Environmental Safety, 2023
UDP-glucuronosyltransferases (UGTs) could transform various exogenous and endogenous compounds, which help detoxification of pesticides in insects. To investigate the role of UGTs in the detoxification metabolism of insecticides in Chironomus kiiensis ...
Chengcheng Fan, Zexiao Cui, Tianying Yang, Lili Sun, Chuanwang Cao   +4 more
doaj   +1 more source

Metabolism of 2,3-Dehydrosilybin A and 2,3-Dehydrosilybin B: A Study with Human Hepatocytes and Recombinant UDP-Glucuronosyltransferases and Sulfotransferases

Antioxidants, 2021
2,3-Dehydrosilybin A and 2,3-dehydrosilybin B are a pair of enantiomers formed by the oxidation of the natural flavonolignans silybin A and silybin B, respectively.
Jiří Vrba, Barbora Papoušková, Kateřina Lněničková, Pavel Kosina, Vladimír Křen, Jitka Ulrichová   +5 more
doaj   +1 more source

A Network-Based Pharmacology Study of the Herb-Induced Liver Injury Potential of Traditional Hepatoprotective Chinese Herbal Medicines [PDF]

, 2017
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Cheung, F, Feng, Y, HONG, M, Huang, J, LI, S, Tan, HY, Wang, N   +6 more
core   +1 more source

Effects of dietary components on testosterone metabolism via UDP‐glucuronosyltransferase (UGT)

Frontiers in Endocrinology, 2013
The potential interference in testosterone metabolism through ingested substances has ramifications for: i) a range of pathologies such as prostate cancer, ii) medication contra-indications, iii) disruption to the endocrine system, and iv) potential ...
Carl eJenkinson, Andrea ePetroczi, Declan P Naughton   +2 more
doaj   +1 more source

Involvement of UDP-Glucuronosyltransferases and Sulfotransferases in the Excretion and Tissue Distribution of Resveratrol in Mice. [PDF]

, 2017
Resveratrol is a naturally occurring polyphenolic compound with various pharmacological activities. It is unknown whether the expression of metabolizing enzymes correlates with resveratrol levels in organs and tissues.
Brenner, Stefan, Böhmdorfer, Michaela, Jäger, Walter, Riha, Juliane, Schiestl, Robert H, Szakmary, Akos, Szekeres, Thomas, Thalhammer, Theresia, Vaquero, Javier   +8 more
core   +2 more sources

Polymorphic expression of UDP-glucuronosyltransferase UGTlA gene in human colorectal cancer. [PDF]

PLoS ONE, 2013
BACKGROUND: Polymorphism of genes encoding drug-metabolizing enzymes is known to play an important role in increased susceptibility of colorectal cancer. UGT1A gene locus has been suggested to define tissue-specific glucuronidation activity.
Min Wang, De-Feng Sun, Shuai Wang, Ying Qing, Shuo Chen, Dong Wu, Ying-Min Lin, Ji-Zhuang Luo, Yan-Qing Li   +8 more
doaj   +1 more source