Results 31 to 40 of about 7,973 (164)

Comparison of the Inhibitory Potential of Bavachalcone and Corylin against UDP-Glucuronosyltransferases [PDF]

, 2014
Bavachalcone and corylin are two major bioactive compounds isolated from Psoralea corylifolia L., which has been widely used as traditional Chinese medicine for many years.
Feng, Yujun, Qiu, Zhenyu, Shan, Lina, Shi, Xianbao, Tian, Lei, Yang, Shuman, Yuan, Hongxia, Zhang, Gang, Zhou, Dun   +8 more
core   +4 more sources

Cytosylglucuronic acid synthase (cytosine: UDP-glucuronosyltransferase) from Streptomyces griseochromogenes, the first prokaryotic UDP-glucuronosyltransferase [PDF]

Journal of Bacteriology, 1994
Cytosylglucuronic acid synthase (cytosine: UDP-glucuronosyltransferase), the first prokaryotic UDP-GT and a key enzyme in the biosynthesis of the antibiotic blasticidin S, was purified 870-fold. It has optimum activity at a pH of 8.4 to 8.6, Kms of 6.0 (UDP-glucuronic acid) and 243 (cytosine) microM, and a maximum rate of metabolism of 14.6 mumol/min ...
S J, Gould, J, Guo
openaire   +2 more sources

Rifampin modulation of xeno- and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes [PDF]

, 2018
Rifampin is a pleiotropic inducer of multiple drug metabolizing enzymes and transporters. This work utilized a global approach to evaluate rifampin effects on conjugating enzyme gene expression with relevance to human xeno- and endo-biotic metabolism ...
Desta, Zeruesenay, Eadon, Michael T., Gao, Hongyu, Gufford, Brandon T., Lin, Hai, Liu, Yunlong, Robarge, Jason D., Skaar, Todd C.   +7 more
core   +1 more source

Demethylzeylasteral Exhibits Strong Inhibition towards UDP-Glucuronosyltransferase (UGT) 1A6 and 2B7

Molecules, 2012
Inhibition of UDP-glucuronosyltransferase (UGT) isoforms can result in severe clinical results, including clinical drug-drug interactions (DDI) and metabolic disorders of endogenous substances.
Xiao-Qi Ji, Lian-Hua Cheng, Jin-Wen Zhao, Min Chen, Gui-Hua Wang   +4 more
doaj   +1 more source

Glucuronidation by UGT1A1 Is the Dominant Pathway of the Metabolic Disposition of Belinostat in Liver Cancer Patients [PDF]

, 2013
10.1371/journal.pone.0054522PLoS ...
A Cashen, A Tumber, AL Yoder Graber, Andrea Li-Ann Wong, Anthony Chan, Boon-Cher Goh, BS Mann, C Marco, CP Strassburg, CS Mitsiades, E Beutler, F Innocenti, F Innocenti, G Giaccone, HJ Mackay, How-Sung Lee, Jacqueline Ramírez, Jie-Ying Amelia Lau, JM Hoskins, John Luk, L Iyer, LH Du, Ling-Zhi Wang, LZ Wang, Mark J. Ratain, Mei-Yi Michelle Chan, MJ Peart, N Tanji, NL Steele, NS Wong, PA Marks, Paul C. Ho, PJ Bosma, RA Howman, RL Piekarz, RL Piekarz, RM Balliet, Robert Lim, S Clive, SA Bapat, Seow-Ching Wan, SG Gray, Sherry Ansher, Soo-Chin Lee, SP Kang, SR Babu, SS Ramalingam, T Izukawa, T Shiraga, W Yeo, Win-Lwin Thuya, Winnie Yeo, Y Dai, Ying-Kiat Zee, YS Na   +54 more
core   +8 more sources

Apalutamide treatment and refractory hypothyroidism: effects of apalutamide on levothyroxine metabolism

European Thyroid Journal
Apalutamide, a selective androgen receptor antagonist, is a new treatment for prostate cancer. Among the side effects observed during apalutamide treatment, an increased risk of hypothyroidism has been reported, particularly in patients previously ...
Florie Quattrochi, Solange Grunenwald, Philippe Caron   +2 more
doaj   +1 more source

Polymorphic expression of UDP-glucuronosyltransferase UGTlA gene in human colorectal cancer.

PLoS ONE, 2013
BackgroundPolymorphism of genes encoding drug-metabolizing enzymes is known to play an important role in increased susceptibility of colorectal cancer. UGT1A gene locus has been suggested to define tissue-specific glucuronidation activity.
Min Wang, De-Feng Sun, Shuai Wang, Ying Qing, Shuo Chen, Dong Wu, Ying-Min Lin, Ji-Zhuang Luo, Yan-Qing Li   +8 more
doaj   +1 more source

UDP-glucuronosyltransferases in sickness and health : Studies on bilirubin and steroid glucuronidation [PDF]

, 2013
UDP-glucuronosyltransferases (UGTs) are responsible for the metabolism of many xenobiotics, as well as several endogenous compounds like bilirubin and certain steroids.
Sneitz, Nina
core  

mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft [PDF]

, 2008
Background Interactions between the gene products encoded by the mitochondrial and nuclear genomes play critical roles in eukaryotic cellular function. However, the effects mitochondrial DNA (mtDNA) levels have on the nuclear transcriptome have not been ...
Darren Magda, Philip Lecane, Julia Prescott, Patricia Thiemann, Xuan Ma, Patricia K Dranchak, Donna M Toleno, Krishna Ramaswamy, Kimberly D Siegmund, Joseph G Hacia   +9 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source