Results 11 to 20 of about 12,748,427 (99)

Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors : toward the development of novel therapies for African sleeping sickness [PDF]

, 2010
Trypanosoma brucei, the causative agent of human African trypanosomiasis, affects tens of thousands of sub-Saharan Africans. As current therapeutics are inadequate due to toxic side effects, drug resistance, and limited effectiveness, novel therapies are
Durrant, Jacob D., Ferguson, Michael A. J., McCammon, J. Andrew, Urbaniak, Michael D.   +3 more
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UDP-N-Acetylglucosamine 4-Epimerase Activity Indicates the Presence of N-Acetylgalactosamine in Exopolysaccharides of Streptococcus thermophilus Strains [PDF]

, 2001
The monomer composition of the exopolysaccharides (EPS) produced by Streptococcus thermophilus LY03 and S. thermophilus Sfi20 were evaluated by high-pressure liquid chromatography with amperometric detection and nuclear magnetic resonance spectroscopy ...
Laws, Andrew P., Degeest, B., Vaningelgem, Frederik, De Vuyst, Luc   +3 more
core   +1 more source

The crystal structure of the Y140F mutant of ADP-L-glycero-D-manno-heptose 6-epimerase bound to ADP-beta-D-mannose suggests a one base mechanism [PDF]

, 2010
Supported by Wellcome Trust grant 081862/Z/06/ZBacteria synthesize a wide array of unusual carbohydrate molecules, which they use in a variety of ways.
Naismith, Jim, Kowatz, Thomas, Tanner, Martin E., Morrison, James P.   +3 more
core   +1 more source

Genome-wide analysis of the UDP-glucose dehydrogenase gene family in Arabidopsis, a key enzyme for matrix polysaccharides in cell walls [PDF]

, 2007
Arabidopsis cell walls contain large amounts of pectins and hemicelluloses, which are predominantly synthesized via the common precursor UDP-glucuronic acid.
Tenhaken, Raimund, Klinghammer, Michaela
core   +1 more source

UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) binds to alpha-actinin 1: novel pathways in skeletal muscle? [PDF]

, 2008
Hereditary inclusion body myopathy (HIBM) is a rare neuromuscular disorder caused by mutations in GNE, the key enzyme in the biosynthetic pathway of sialic acid.
North Kathryn N., Mitrani-Rosenbaum, S, Shira Amsili, Stephan Hinderlich, Krause, S, Hinderlich Stephan, Hagit Zer, MacArthur, DG, Mitrani-Rosenbaum Stella, Mitrani-Rosenbaum, Stella, Zer, Hagit, Amsili Shira, Becker-Cohen, M, Hinderlich, S, Amsili, S, Becker-Cohen Michal, Krause, Sabine, Krause Sabine, Kathryn N North, North, Kathryn N., Zer Hagit, Sabine Krause, Daniel G MacArthur, Hinderlich, Stephan, Michal Becker-Cohen, MacArthur Daniel G., Zer, H, MacArthur, Daniel G., Stella Mitrani-Rosenbaum, Becker-Cohen, Michal, Amsili, Shira, North, KN   +31 more
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FolX from Pseudomonas aeruginosa is octameric in both crystal and solution [PDF]

, 2012
FolX encodes an epimerase that forms one step of the tetrahydrofolate biosynthetic pathway, which is of interest as it is an established target for important drugs.
Byron, Olwyn, Gabrielsen, M., Beckham, K.S.H., Cogdell, R.J., Roe, A.J., Gabrielsen, Mads, Roe, Andrew J., Byron, O., Beckham, Katherine S.H., Cogdell, Richard J.   +9 more
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Activation of Silent gal Genes in the lac-gal Regulon of Streptococcus thermophilus [PDF]

, 2001
Streptococcus thermophilus strain CNRZ 302 is unable to ferment galactose, neither that generated intracellularly by lactose hydrolysis nor the free sugar.
Vos, W.M., de, Kuipers, Oscar P.; id_orcid, Kuipers, Oscar P., van den Bogaard, P.T.C., Catzeddu, Pasquale,, Bogaard, Patrick T.C. van den, Vaughan, Elaine E., Bogaard, P.T.C., van den, Vaughan, E.E., Kuipers, Oscar P.,, Bogaard, Patrick T.C. van den,, Kuipers, O.P., Vaughan, Elaine E.,, Vos, Willem M. de, Vos, Willem M. de,, de Vos, W.M., Catzeddu, Pasquale, Catzeddu, P.   +17 more
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Synthesis of N-acetylmannosamine-6-phosphate derivatives to investigate the mechanism of N-acetylmannosamine-6-phosphate 2-epimerase

, 2021
The synthesis of analogues of natural enzyme substrates can be used to help deduce enzymatic mechanisms. N-Acetylmannosamine-6-phosphate 2-epimerase is an enzyme in the bacterial sialic acid catabolic pathway. To investigate whether the mechanism of this
Tanzeel Arif (8511357), MJ Currie (13197516), RA North (7637255), V Poonthiyil (18960694), RCJ Dobson (13197519), HL Newson (18960691), Phillip Rendle (8510118), AJ Fairbanks (18960697)   +7 more
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Mechanisms of silicate polymerisation, carbohydrate epimerisation and metalloprotease inhibition [PDF]

, 2009
In biotechnology and drug delivery silica materials are of interest but the controlled generation of silicic acid is difficult. To get more insight into the molecular mechanisms that control biosilification, it is important to study the proteins involved
Kowatz, Thomas
core   +2 more sources

UDP-Glucose 4-epimerase from Saccharomyces fragilis. Involvement of sulfhydryl group(s) at the active site

, 1978
UDPglucose 4-epimerase (EC 5.1.3.2) from Saccharomyces fragilis is inactivated by 0.1 mM 5,5'-dithiobis-(2-nitrobenzoate) in 6 min. Unlike p-chloromercuribenzoate-inactivated or heat-inactivated enzymes, the dithiobisnitrobenzoate-inactivated enzyme ...
Kar, Kuntala, Bhaduri, Amar, Ray, Manju
core   +1 more source