Results 71 to 80 of about 2,195 (166)

New Insights Into the Regulation of Natural-Killer Group 2 Member D (NKG2D) and NKG2D-Ligands: Endoplasmic Reticulum Stress and CEA-Related Cell Adhesion Molecule 1

open access: yesFrontiers in Immunology, 2018
Natural-killer group 2 member D (NKG2D) is a well-characterized activating receptor expressed by natural killer (NK) cells, NKT cells, activated CD8+ T cells, subsets of γδ+ T cells, and innate-like T cells.
Shuhei Hosomi   +6 more
doaj   +1 more source

Single‐Cell Transcriptomics Reveals Biomarkers for NK Cell Dysfunction in Endometriosis‐Associated Immune Dysregulation

open access: yesMediators of Inflammation, Volume 2026, Issue 1, 2026.
Background Endometriosis (EM) is associated with immune dysregulation, while dysfunction of natural killer (NK) cells is regarded as a key mechanism underlying immune escape and the persistent growth of ectopic lesions. Method This study used single‐cell RNA sequencing (scRNA‐seq) on lesions from three patients with EM and on three normal endometrium ...
Wangshu Li   +9 more
wiley   +1 more source

Crowd Density Estimation of Scenic Spots Based on Multifeature Ensemble Learning

open access: yesJournal of Electrical and Computer Engineering, 2017
Estimating the crowd density of public territories, such as scenic spots, is of great importance for ensuring population safety and social stability.
Xiaohang Xu, Dongming Zhang, Hong Zheng
doaj   +1 more source

The Biological Influence and Clinical Relevance of Polymorphism Within the NKG2D Ligands

open access: yesFrontiers in Immunology, 2018
NKG2D is a major regulator of the activity of cytotoxic cells and interacts with eight different ligands (NKG2DL) from two families of MIC and ULBP proteins.
Jianmin Zuo, Fiyaz Mohammed, Paul Moss
doaj   +1 more source

CEBPA Gene Mutations Interfere with Expressions of NKG2D Ligands Ulbps in AML Cells and Modulate Their Susceptibility to NK-Mediated Lysis

open access: yesBlood, 2019
Introduction: CEBPA gene encodes CCAAT/enhancer-binding protein-alpha (C/EBPα), a crucial granulocytic differentiation factor and tumor suppressor in hematologic and many non-hematologic malignancies. We previously reported a donor-derived relapse of AML patient after allogeneic hematopoietic stem cell transplantation with multiple mutations in CEBPA ...
Meng Liu   +5 more
openaire   +1 more source

Vesicular stomatitis virus infection promotes immune evasion by preventing NKG2D-ligand surface expression.

open access: yesPLoS ONE, 2011
Vesicular stomatitis virus (VSV) has recently gained attention for its oncolytic ability in cancer treatment. Initially, we hypothesized that VSV infection could increase immune recognition of cancer cells through induction of the immune stimulatory ...
Helle Jensen   +4 more
doaj   +1 more source

The Immunoinformatic, Structural elucidation of ULBP2 Protein in the therapeutics of Tumorigenesis: Using Bioinformatics Approaches

open access: yesEuropean Journal of Volunteering and Community-Based Projects, 2021
The Natural killer (NK) cells' ability to destroy cancerous cells is predominantly focused on the activation of the co-stimulatory and natural killer group two with receptor of member-D also called NKGD2/NKG2D.
Muhammad Mazhar Fareed   +3 more
doaj   +2 more sources

Uniform Local Binary Pattern for Fingerprint Liveness Detection in the Gaussian Pyramid

open access: yesJournal of Electrical and Computer Engineering, 2018
Fingerprint recognition schemas are widely used in our daily life, such as Door Security, Identification, and Phone Verification. However, the existing problem is that fingerprint recognition systems are easily tricked by fake fingerprints for ...
Yujia Jiang, Xin Liu
doaj   +1 more source

NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human γδ T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors

open access: yesOncoImmunology, 2016
The interaction of the MHC class I-related chain molecules A and B (MICA and MICB) and UL-16 binding protein (ULBP) family members expressed on tumor cells with the corresponding NKG2D receptor triggers cytotoxic effector functions in NK cells and γδ T ...
Guranda Chitadze   +10 more
doaj   +1 more source

A Concise Review of the Role of the NKG2D Receptor and Its Ligands in Cancer

open access: yesImmuno
The immune system’s ability to detect and eliminate transformed cells is a critical factor in suppressing cancer development. However, immune surveillance in tumors is often disrupted by various immune escape mechanisms, many of which remain poorly ...
Elitsa Boneva   +2 more
doaj   +1 more source

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