Results 51 to 60 of about 2,195 (166)

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

open access: yesPediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean   +7 more
wiley   +1 more source

Glycosyl-phosphatidyl-inositol (GPI)-anchors and metalloproteases: their roles in the regulation of exosome composition and NKG2D-mediated immune recognition

open access: yesFrontiers in Cell and Developmental Biology, 2016
Communication within the immune system depends on the release of factors that can travel and transmit information at points distant from the cell that produced them.
Sheila López-Cobo   +2 more
doaj   +1 more source

The Role of Natural Killer (NK) Cells in Dengue Virus Infection: A Narrative Review

open access: yesHealth Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims In the innate immune response, natural Killer (NK) cells have a significant role in protection against viral infections, including the Dengue virus (DENV). NK cells identify and eliminate virus‐infected cells through diverse mechanisms, such as cytokine production, cytolytic activity, and antibody‐dependent cellular ...
Farjana Islam
wiley   +1 more source

Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host

open access: yesReviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
E. Cimini   +4 more
wiley   +1 more source

A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression

open access: yeseLife, 2016
Natural Killer (NK) cells are essential for control of viral infection and cancer. NK cells express NKG2D, an activating receptor that directly recognizes NKG2D ligands.
Trever T Greene   +9 more
doaj   +1 more source

Botanical Leaf Disease Detection and Classification Using Convolutional Neural Network: A Hybrid Metaheuristic Enabled Approach

open access: yesComputers, 2022
Botanical plants suffer from several types of diseases that must be identified early to improve the production of fruits and vegetables. Mango fruit is one of the most popular and desirable fruits worldwide due to its taste and richness in vitamins ...
Madhumini Mohapatra   +4 more
doaj   +1 more source

SLPI/FBW7/c‐Myc Axis Reduces Gemcitabine Sensitivity in PDAC by Enhancing Glycolysis and Impairing NK Cell Immunity

open access: yesCancer Science, Volume 117, Issue 6, Page 1635-1650, June 2026.
SLPI reduces the sensitivity of PDAC to gemcitabine by competing with FBW7 for binding to c‐Myc, thereby disrupting FBW7‐dependent ubiquitination and proteasomal degradation of c‐Myc, leading to increased c‐Myc stability and expression. SLPI knockdown could significantly increase gemcitabine sensitivity to gemcitabine‐induced direct cytotoxicity and NK
Haofei Chen   +7 more
wiley   +1 more source

Molecular bases for the regulation of NKG2D ligands in cancer

open access: yesFrontiers in Immunology, 2014
NKG2D is an activating receptor expressed by NK and T cells primarily involved in the elimination of transformed and infected cells. NKG2D ligands are self-proteins restrictedly expressed in healthy tissues, but induced in response to signaling pathways ...
Leticia eHuergo-Zapico   +5 more
doaj   +1 more source

ULBPs, Novel MHC Class I–Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxicity through the NKG2D Receptor [PDF]

open access: yesImmunity, 2001
The human cytomegalovirus glycoprotein, UL16, binds to two members of a novel family of molecules, the ULBPs, and to the MHC class I homolog, MICB. The ULBPs are GPI-linked glycoproteins belonging to the extended MHC class I family but are only distantly related to MICB.
Cosman, David   +7 more
openaire   +2 more sources

Characterisation of tumor‐infiltrating gamma‐delta T cells in human colorectal cancer with MHC‐I loss

open access: yesClinical &Translational Immunology, Volume 15, Issue 5, 2026.
Abstract Objectives Gamma‐delta (γδ) T cells have been associated with favorable prognoses across several malignancies, underscoring their potential as targets for novel immunotherapies. These unconventional T lymphocytes exhibit an intrinsic tropism for the tumor microenvironment, largely driven by their capacity to recognize stress‐induced antigens ...
Tianming A Li   +6 more
wiley   +1 more source

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