Results 51 to 60 of about 2,195 (166)
Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source
Communication within the immune system depends on the release of factors that can travel and transmit information at points distant from the cell that produced them.
Sheila López-Cobo +2 more
doaj +1 more source
The Role of Natural Killer (NK) Cells in Dengue Virus Infection: A Narrative Review
ABSTRACT Background and Aims In the innate immune response, natural Killer (NK) cells have a significant role in protection against viral infections, including the Dengue virus (DENV). NK cells identify and eliminate virus‐infected cells through diverse mechanisms, such as cytokine production, cytolytic activity, and antibody‐dependent cellular ...
Farjana Islam
wiley +1 more source
Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host
ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
E. Cimini +4 more
wiley +1 more source
Natural Killer (NK) cells are essential for control of viral infection and cancer. NK cells express NKG2D, an activating receptor that directly recognizes NKG2D ligands.
Trever T Greene +9 more
doaj +1 more source
Botanical plants suffer from several types of diseases that must be identified early to improve the production of fruits and vegetables. Mango fruit is one of the most popular and desirable fruits worldwide due to its taste and richness in vitamins ...
Madhumini Mohapatra +4 more
doaj +1 more source
SLPI reduces the sensitivity of PDAC to gemcitabine by competing with FBW7 for binding to c‐Myc, thereby disrupting FBW7‐dependent ubiquitination and proteasomal degradation of c‐Myc, leading to increased c‐Myc stability and expression. SLPI knockdown could significantly increase gemcitabine sensitivity to gemcitabine‐induced direct cytotoxicity and NK
Haofei Chen +7 more
wiley +1 more source
Molecular bases for the regulation of NKG2D ligands in cancer
NKG2D is an activating receptor expressed by NK and T cells primarily involved in the elimination of transformed and infected cells. NKG2D ligands are self-proteins restrictedly expressed in healthy tissues, but induced in response to signaling pathways ...
Leticia eHuergo-Zapico +5 more
doaj +1 more source
ULBPs, Novel MHC Class I–Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxicity through the NKG2D Receptor [PDF]
The human cytomegalovirus glycoprotein, UL16, binds to two members of a novel family of molecules, the ULBPs, and to the MHC class I homolog, MICB. The ULBPs are GPI-linked glycoproteins belonging to the extended MHC class I family but are only distantly related to MICB.
Cosman, David +7 more
openaire +2 more sources
Abstract Objectives Gamma‐delta (γδ) T cells have been associated with favorable prognoses across several malignancies, underscoring their potential as targets for novel immunotherapies. These unconventional T lymphocytes exhibit an intrinsic tropism for the tumor microenvironment, largely driven by their capacity to recognize stress‐induced antigens ...
Tianming A Li +6 more
wiley +1 more source

