Results 31 to 40 of about 2,195 (166)

An Application of Hyperspectral Image Clustering Based on Texture-Aware Superpixel Technique in Deep Sea

Remote Sensing, 2022
This paper aims to study the application of hyperspectral technology in the classification of deep-sea manganese nodules. Considering the spectral spatial variation of hyperspectral images, the difficulty of label acquisition, and the inability to ...
Panjian Ye, Chenhua Han, Qizhong Zhang, Farong Gao, Zhangyi Yang, Guanghai Wu   +5 more
doaj   +1 more source

HDAC3 represses the expression of NKG2D ligands ULBPs in epithelial tumour cells: potential implications for the immunosurveillance of cancer [PDF]

Oncogene, 2009
The expression of the NKG2D ligands on cancer cells leads to their recognition and elimination by host immune responses mediated by natural killer and T cells. UL16-binding proteins (ULBPs) are NKG2D ligands, which are scarcely expressed in epithelial tumours, favouring their evasion from the immune system.
A, López-Soto, A R, Folgueras, E, Seto, S, Gonzalez   +3 more
openaire   +3 more sources

The RNA binding protein IMP3 facilitates tumor immune escape by downregulating the stress-induced ligands ULPB2 and MICB

eLife, 2016
Expression of the stress-induced ligands MICA, MICB and ULBP 1–6 are up-regulated as a cellular response to DNA damage, excessive proliferation or viral infection; thereby, they enable recognition and annihilation by immune cells that express the ...
Dominik Schmiedel, Julie Tai, Rachel Yamin, Orit Berhani, Yoav Bauman, Ofer Mandelboim   +5 more
doaj   +1 more source

Expresión génica de ligandos mica, micb y ulbp (1-6) del receptor NKG2D de células natural killer y metaloproteinasas adam10, adam17 y mmp14 en lineas celulares de cancer de cervical

Revista Colombiana de Biotecnología, 2019
El CCU es la segunda causa de muerte en mujeres de nuestro país. Dentro de los primeros mecanismos de defensa del hospedero se encuentra la respuesta inmune de las células NK y su función lítica a expensas de su receptor activador NKG2D, el cual posee ...
Dabeiba Adriana García, Pilar Pérez, Laura García, Angel Cid-Arregui, Fabio Aristizabal   +4 more
doaj   +1 more source

Transfer of the human NKG2D ligands UL16 binding proteins (ULBP) 1–3 is related to lytic granule release and leads to ligand retransfer and killing of ULBP‐recipient natural killer cells [PDF]

Immunology, 2015
SummaryAfter immune interactions, membrane fragments can be transferred between cells. This fast transfer of molecules is transient and shows selectivity for certain proteins; however, the constraints underlying acquisition of a protein are unknown. To characterize the mechanism and functional consequences of this process in natural killer (NK) cells ...
López-Cobo, Sheila, Romera-Cárdenas, Gema, García-Cuesta, Eva María, Reyburn, H. T., Valés-Gómez, Mar   +4 more
openaire   +3 more sources

Human NKG2D-ligands: cell biology strategies to ensure immune recognition

Frontiers in Immunology, 2012
Immune recognition mediated by the activating receptor NKG2D plays an important role for the elimination of stressed cells, including tumours and virus-infected cells.
Lola eFernández-Messina, Hugh T. Reyburn, Mar eVales-Gomez   +2 more
doaj   +1 more source

CEBPA mutants down-regulate AML cell susceptibility to NK-mediated lysis by disruption of the expression of NKG2D ligands, which can be restored by LSD1 inhibition

OncoImmunology, 2022
NK group 2, member D (NKG2D) is one of the most critical activating receptors expressed by natural killer (NK) cells. There is growing evidence that acute myeloid leukemia (AML) cells may evade NK cell-mediated cell lysis by expressing low or no ligands ...
Meng Liu, Mengbao Du, Jian Yu, Zijun Qian, Yang Gao, Wenjue Pan, Xiujie Zhao, Mowang Wang, Huimin Li, Jiaqi Zheng, Qianshuo Huang, Li-Mengmeng Wang, Haowen Xiao   +12 more
doaj   +1 more source

Histone Deacetylase Inhibitor Modulates NKG2D Receptor Expression and Memory Phenotype of Human Gamma/Delta T Cells Upon Interaction With Tumor Cells

Frontiers in Immunology, 2019
The functional plasticity and anti-tumor potential of human γδ T cells have been widely studied. However, the epigenetic regulation of γδ T-cell/tumor cell interactions has been poorly investigated.
Jaydeep Bhat, Samuel Dubin, Alexandra Dananberg, Elgar Susanne Quabius, Elgar Susanne Quabius, Juergen Fritsch, C. Marie Dowds, C. Marie Dowds, Ankit Saxena, Guranda Chitadze, Marcus Lettau, Dieter Kabelitz   +11 more
doaj   +1 more source

Machine learning and uLBP histograms for posture recognition of dependent people via Big Data Hadoop and Spark platform

INTERNATIONAL JOURNAL OF COMPUTERS COMMUNICATIONS & CONTROL, 2023
For dependent population, falls accident are a serious health issue, particularly in a situation of pandemic saturation of health structures. It is, therefore, highly desirable to quarantine patients at home, in order to avoid the spread of contagious diseases.
Fayez Alfayez, Heni Bouhamed
openaire   +2 more sources

Recognition of adult and pediatric acute lymphoblastic leukemia blasts by natural killer cells

Haematologica, 2014
In this study, we aimed to investigate the pathways of recognition of acute lymphoblastic leukemia blasts by natural killer cells and to verify whether differences in natural killer cell activating receptor ligand expression among groups defined by age ...
Giovanni F. Torelli, Nadia Peragine, Sara Raponi, Daria Pagliara, Maria S. De Propris, Antonella Vitale, Alice Bertaina, Walter Barberi, Lorenzo Moretta, Giuseppe Basso, Angela Santoni, Anna Guarini, Franco Locatelli, Robin Foà   +13 more
doaj   +1 more source