Deciphering Ultra-High Dose Rate Irradiation with Drosophila melanogaster [PDF]
AntioxidantsFLASH RT, which employs ultra-high dose rates (UHDR), has shown potential in reducing irradiation-induced damage to normal tissue while maintaining effective tumor targeting.
Marvin Kreuzer +10 more
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The sparing effect of ultra-high dose rate irradiation on the esophagus [PDF]
Frontiers in OncologyBackground and purposeCurrent studies have substantiated the sparing effect of ultra-high dose rate irradiation (FLASH) in various organs including the brain, lungs, and intestines.
Wenting Ren +14 more
doaj +2 more sources
Mitochondrial remodeling after conventional and ultra-high dose rate irradiation in head and neck carcinoma cells in vitro [PDF]
Clinical and Translational Radiation OncologyBackground and purpose: Ultra-high dose rate (UHDR) irradiation is being investigated as a strategy to widen the therapeutic window of radiotherapy, but the biological mechanisms that distinguish UHDR from conventional dose rate (CONV) irradiation remain
Liliana L. Silva +8 more
doaj +2 more sources
Proton-FLASH: effects of ultra-high dose rate irradiation on an in-vivo mouse ear model [PDF]
Scientific ReportsFLASH-radiotherapy may provide significant sparing of healthy tissue through ultra-high dose rates in protons, electrons, and x-rays while maintaining the tumor control.
Sarah Rudigkeit +10 more
doaj +2 more sources
Ultra-high-dose-rate pulsed irradiation and the conditional FLASH effect: dosimetry, multiscale biology, and clinical translation [PDF]
Frontiers in OncologyUltra-high-dose-rate (UHDR) pulsed irradiation can deliver therapeutic doses within an extremely short time window, but UHDR is a physical delivery state, whereas the FLASH effect is a conditional comparative phenotype in which normal-tissue injury is ...
Jincheng Zhang +5 more
doaj +2 more sources
New modalities for ultra-high dose rate irradiation and FLASH experiments [PDF]
Physics and Imaging in Radiation OncologyGabriel Adrian +4 more
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FLASH effect tissue sparing comparison for X-ray, hadron, and VHEE irradiation modalities [PDF]
Scientific ReportsFLASH-RT is an irradiation modality using Ultra-High-Dose-Rates, where a healthy tissue sparing effect is observed. Different particle types have distinct characteristics in lateral and distal dose deposition, which can affect the amount of healthy ...
Atia Ibrahimi +4 more
doaj +2 more sources
Radiobiology and treatment plan progress of FLASH radiotherapy
Fushe yanjiu yu fushe gongyi xuebao, 2023 FLASH radiotherapy is a novel method that has the potential to improve the therapeutic gain ratio to a new level. FLASH radiotherapy technology is mainly characterized by irradiation at ultra-high dose rate, which can reduce radiation-induced injury to ...
WU Xun +3 more
doaj +1 more source
Cancer Cells Can Exhibit a Sparing FLASH Effect at Low Doses Under Normoxic In Vitro-Conditions
Frontiers in Oncology, 2021 BackgroundIrradiation with ultra-high dose rate (FLASH) has been shown to spare normal tissue without hampering tumor control in several in vivo studies. Few cell lines have been investigated in vitro, and previous results are inconsistent. Assuming that
Gabriel Adrian +12 more
doaj +1 more source
Real-time monitoring of ultra-high dose rate electron beams using bremsstrahlung photons
Nuclear Engineering and Technology, 2023 Recently, as the clinically positive biological effects of ultra-high dose rate (UHDR) radiation beams have been revealed, interest in flash radiation therapy has increased. Generally, FLASH preclinical experiments are performed using UHDR electron beams
Hyun Kim +6 more
doaj +1 more source