Results 21 to 30 of about 17,118 (204)
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Verification Study on Biological Effect of Ultra-high Dose Rate Proton at Spread-out Bragg Peak
Yuanzineng kexue jishuProton irradiation with an ultra-high dose rate, known as FLASH, is considered to have a protective effect on normal tissues in clinical practice. To better combine the advantageous technologies of spread-out Bragg peak (SOBP) and ultra-high dose rate ...
WANG Yue, WANG Qiaojuan, LIU Jiancheng, LI Ling, HUANG Zhihao, SUI Li
doaj +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Frontiers in PhysicsFLASH radiotherapy, which refers to the delivery of radiation at ultra-high dose-rates (UHDRs), has been demonstrated with various forms of radiation and is the subject of intense research and development recently, including the use of very high-energy ...
James Cayley +6 more
doaj +1 more source
Radiation Oncology, 2022 Background There is currently significant interest in assessing the role of oxygen in the radiobiological effects at ultra-high dose rates. Oxygen modulation is postulated to play a role in the enhanced sparing effect observed in FLASH radiotherapy ...
Pankaj Chaudhary +22 more
doaj +1 more source
Effect of terahertz irradiation on DNA damage repair in living cells
FEBS Open Bio, EarlyView.We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno +3 more
wiley +1 more source
Scientific ReportsFLASH radiotherapy, defined by ultra-high dose rates exceeding 40 Gy/s, has shown potential for widening the therapeutic window due to its demonstrated normal tissue-sparing effects while maintaining tumor control with electrons, photons, and protons ...
Yukari Yoshida +7 more
doaj +1 more source
Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling
FEBS Open Bio, EarlyView.Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt +2 more
wiley +1 more source
Ultra-high dose rate electron FLASH beam irradiation using a modified clinical linear accelerator.
PLoS ONEFLASH radiation therapy reduced radiation-induced damage to normal tissue, compared to conventional radiation therapy, and active studies have been undertaken worldwide.
Gyu-Seok Cho +17 more
doaj +1 more source