Results 11 to 20 of about 17,118 (204)

Abdominal FLASH irradiation reduces radiation-induced gastrointestinal toxicity for the treatment of ovarian cancer in mice

Scientific Reports, 2020
Radiation therapy is the most effective cytotoxic therapy for localized tumors. However, normal tissue toxicity limits the radiation dose and the curative potential of radiation therapy when treating larger target volumes.
Karen Levy, Suchitra Natarajan, Jinghui Wang, Stephanie Chow, Joshua T. Eggold, Phoebe E. Loo, Rakesh Manjappa, Stavros Melemenidis, Frederick M. Lartey, Emil Schüler, Lawrie Skinner, Marjan Rafat, Ryan Ko, Anna Kim, Duaa H. Al-Rawi, Rie von Eyben, Oliver Dorigo, Kerriann M. Casey, Edward E. Graves, Karl Bush, Amy S. Yu, Albert C. Koong, Peter G. Maxim, Billy W. Loo, Erinn B. Rankin   +24 more
doaj   +1 more source

Use of the chemical Fricke dosimeter and its modifications for dosimetry of gamma neutron radiation of a pulsed reactor [PDF]

Nuclear Energy and Technology, 2021
The paper investigates the characteristics of the chemical Fricke dosimeter (with the standard composition (D1), without NaCl addition to the solution (D2), without NaCl but with a tenfold increased concentration of Fe2+ (D3)) under continuous and pulsed
Vladimir I. Potetnya, Ekaterina V. Koryakina, Marina V. Troshina, Sergey N. Koryakin   +3 more
doaj   +3 more sources

Design of an ultra-high dose rate cell irradiation experimental platform using a medical proton linear injector

He jishu, 2023
BackgroundUltra-high dose rate (UHDR) radiation of electron or proton beam has been shown to spare normal tissues surrounding the tumors while killing tumor cells effectively which is called the FLASH effect (FE).
LIU Junya, YU Xiao, WU Chao, SUN Xiangshang, SHANG Haijiao, LIAO Wentao, YAN Nan, ZHOU Yun, PU Yuehu   +8 more
doaj   +1 more source

Ultra-High Dose Rate FLASH Irradiation Induced Radio-Resistance of Normal Fibroblast Cells Can Be Enhanced by Hypoxia and Mitochondrial Dysfunction Resulting From Loss of Cytochrome C

Frontiers in Cell and Developmental Biology, 2021
Ultra-high dose rate FLASH irradiation (FLASH-IR) has got extensive attention since it may provide better protection on normal tissues while maintain tumor killing effect compared with conventional dose rate irradiation.
Jintao Han, Zhusong Mei, Chunyang Lu, Jing Qian, Yulan Liang, Xiaoyi Sun, Zhuo Pan, Defeng Kong, Shirui Xu, Zhipeng Liu, Ying Gao, Guijun Qi, Yinren Shou, Shiyou Chen, Zhengxuan Cao, Ye Zhao, Chen Lin, Yanying Zhao, Yixing Geng, Jiaer Chen, Xueqing Yan, Xueqing Yan, Wenjun Ma, Gen Yang   +23 more
doaj   +1 more source

Association of Cancer Stem Cell Radio-Resistance Under Ultra-High Dose Rate FLASH Irradiation With Lysosome-Mediated Autophagy

Frontiers in Cell and Developmental Biology, 2021
Cancer stem cell (CSC) is thought to be the major cause of radio-resistance and relapse post radiotherapy (RT). Recently ultra-high dose rate “FLASH-RT” evokes great interest for its decreasing normal tissue damages while maintaining tumor responses ...
Gen Yang, Chunyang Lu, Zhusong Mei, Xiaoyi Sun, Jintao Han, Jing Qian, Yulan Liang, Zhuo Pan, Defeng Kong, Shirui Xu, Zhipeng Liu, Ying Gao, Guijun Qi, Yinren Shou, Shiyou Chen, Zhengxuan Cao, Ye Zhao, Chen Lin, Yanying Zhao, Yixing Geng, Wenjun Ma, Xueqing Yan, Xueqing Yan   +22 more
doaj   +1 more source

The FLASH effect—an evaluation of preclinical studies of ultra-high dose rate radiotherapy

Frontiers in Oncology
FLASH radiotherapy (FLASH-RT) is a novel radiotherapy approach based on the use of ultra-high dose radiation to treat malignant cells. Although tumours can be reduced or eradicated using radiotherapy, toxicities induced by radiation can compromise ...
Josie May McGarrigle, Kenneth Richard Long, Kenneth Richard Long, Yolanda Prezado, Yolanda Prezado   +4 more
doaj   +1 more source

Instantaneous dose rate as a crucial factor in reducing mortality and normal tissue toxicities in murine total-body irradiation: a comparative study of dose rate combinations

Molecular Medicine
Purpose The ultra-high dose rate (UHDR) radiation shows promise in eradicating tumors while reducing normal tissue toxicities. However, the biological outcomes of UHDR are influenced by various factors, particularly the mean dose rate and instantaneous ...
Hongyu Zhu, Shihua Liu, Jiaqi Qiu, Ankang Hu, Wanyi Zhou, Jian Wang, Weihang Gu, Yinuo Zhu, Hao Zha, Rong Xiang, Junli Li, Rui Qiu, Chong Zhao, Peng Huang, Xiaowu Deng   +14 more
doaj   +1 more source

First in vitro and in vivo experiments with ultra high-dose rate oxygen ion radiotherapy

Physics and Imaging in Radiation Oncology
Within this study, we demonstrated the feasibility of ultra-high dose rate (UHDR) oxygen ion irradiation at three different levels of biological complexity. The difference in oxygen consumption between UHDR and standard dose rates (SDR) was negligible in
Celine Karle, Domenico I. Filosa, Mahdi Akbarpour, Nora Schuhmacher, Stephan Brons, Rainer Cee, Christian Schömers, Stefan Scheloske, Kristoffer Petersson, Thomas Haberer, Amir Abdollahi, Jürgen Debus, Thomas Tessonnier, Mahmoud Moustafa, Andrea Mairani, Ivana Dokic   +15 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source