Results 261 to 270 of about 73,799 (284)

Uncoupling Proteins 1 and 3 Are Regulated Differently

Biochemistry, 2000
Using a heterologous yeast expression system, we have previously found a marked discordance between the effects of uncoupling protein (UCP) 1 and UCP3L on basal O(2) consumption in whole yeast versus isolated mitochondria. In whole yeast, UCP3L produces a greater stimulation of basal O(2) consumption, while in isolated mitochondria, UCP1 produces a ...
T, Hagen, C Y, Zhang, C R, Vianna, B B, Lowell   +3 more
openaire   +2 more sources

A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast

Biochemical Journal, 2001
Uncoupling protein 1 (UCP1) from mouse was expressed in yeast and the specific (GDP-inhibitable) and artifactual (GDP-insensitive) effects on mitochondrial uncoupling were assessed. UCP1 provides a GDP-inhibitable model system to help interpret the uncoupling effects of high expression in yeast of other members of the mitochondrial carrier protein ...
J A, Stuart, J A, Harper, K M, Brindle, M B, Jekabsons, M D, Brand   +4 more
openaire   +2 more sources

Uncoupling protein 1 expression and high-fat diets

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2011
Uncoupling protein 1 (Ucp1) is the key component of β-adrenergically controlled nonshivering thermogenesis in brown adipocytes. This process combusts stored and nutrient energy as heat. Cold exposure not only activates Ucp1-mediated thermogenesis to maintain normothermia but also results in adaptive thermogenesis, i.e., the recruitment of thermogenic ...
Tobias, Fromme, Martin, Klingenspor
openaire   +2 more sources

Uncoupling protein 1 in nonadipose tissue

American Journal of Physiology-Endocrinology and Metabolism
Our findings reveal UCP1 expression begins from E10.5, particularly in the brain, kidney, ear, eye, mammary gland, and reproductive system. During embryonic development, UCP1 expression is more prevalent in nonadipose tissues, compared to adulthood, especially in epithelial cells.
Xi Hu, Donghua Hu, Kun Chen, Mengjiao Xu, Yaying Chen, Lisheng Fu, Deping Wu, Xinkai Qu, Jiqiu Wang, Chengchao Ruan, Junfeng Cai, Kailei Shi, Maoqing Ye   +12 more
openaire   +2 more sources

An immunohistochemical and in situ hybridisation study of the postnatal development of uncoupling protein-1 and uncoupling protein-1 mRNA in lamb perirenal adipose tissue

Cell and Tissue Research, 1998
In the lamb, the uncoupling protein-1 (UCP1) content of perirenal adipose tissue at birth is an important factor in heat production by non-shivering thermogenesis and the prevention of hypothermia. This study examines UCP1 gene expression and protein content in perirenal adipose tissue over the first 15 days of life by in situ hybridisation and ...
D, Finn, M A, Lomax, P, Trayhurn
openaire   +2 more sources

Uncoupling protein 1: a short-circuit in the chemiosmotic process

Journal of Bioenergetics and Biomembranes, 2008
One of the significant naturally occurring short-circuits in the chemiosmotic process is manifest through the activity of uncoupling protein 1, most notably present in the inner membrane of mitochondria in brown adipose tissue. Much has been learnt about the mechanism of action of uncoupling protein 1 since its discovery in the 1970's, yet many areas ...
openaire   +2 more sources

Uncoupling protein 1 contributes to fat-reducing effect of leptin

Obesity Research & Clinical Practice, 2007
Leptin is proposed to reduce body fat by increasing energy expenditure, in addition to decreasing food intake, through the activation of brown adipose tissue (BAT) thermogenesis. To confirm this, we investigated the effects of leptin on whole body energy expenditure, BAT functions and adiposity in wild-type (WT) mice, and compared with those in mice ...
Yuko, Okamatsu-Ogura, Akihiro, Uozumi, Chitoku, Toda, Kazuhiro, Kimura, Hitoshi, Yamashita, Masayuki, Saito   +5 more
openaire   +2 more sources

Ibuprofen, a direct activator of uncoupling protein 1

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2022
Riccardo Cavalieri, Marlou Klein Hazebroek, Camila A. Cotrim, Yang Lee, Edmund R.S. Kunji, Martin Jastroch, Susanne Keipert, Paul G. Crichton   +7 more
openaire   +1 more source

Expression of uncoupling protein 1 in bovine muscle cells.

Journal of animal science, 2017
Uncoupling protein 1 (Ucp1) is predominantly expressed in brown/beige adipocytes in mammals. Although myogenic cells have been suggested to commit to a brown adipocyte lineage through the induction of Prdm16 expression, Prdm16 is also expressed in skeletal muscle. Thus, we examined expression of Ucp1 in bovine myogenic cells. Considering that Ucp1 is a
M A, Abd Eldaim, O, Hashimoto, H, Ohtsuki, T, Yamada, M, Murakami, K, Onda, R, Sato, Y, Kanamori, Y, Qiao, S, Tomonaga, T, Matsui, M, Funaba   +11 more
openaire   +1 more source

Uncoupling protein-3 gene expression in skeletal muscle during development is regulated by nutritional factors that alter circulating non-esterified fatty acids

FEBS Letters, 1999
T Mampel, O Vinas, Marta Giralt
exaly