Results 271 to 280 of about 1,699,867 (343)

Human adipose tissue expression of uncoupling protein 1 in response to intravenous administration of B-type natriuretic peptide hormone: Results from a randomized controlled crossover study. [PDF]

Diabetes Obes Metab
Bachmann KN, Ceddia RP, Gupta DK, Collins S, Wang TJ.   +4 more
europepmc   +1 more source

The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1. [PDF]

J Biol Chem, 2020
Sugawara S, Kanamaru Y, Sekine S, Maekawa L, Takahashi A, Yamamoto T, Watanabe K, Fujisawa T, Hattori K, Ichijo H.   +9 more
europepmc   +1 more source

An investigation into the role and regulation of uncoupling protein 1 (UCP 1)

, 2011
The use of the uncoupling protein inhibitor GDP was used to investigate UCP 1 dependent ROS production in BAT and thymus mitochondria. The effect of UCP 1 inhibition by GDP was then corroborated using UCP 1 ablated mice and their wild-type controls. It was shown that UCP 1 was capable of attenuating ROS production in isolated BAT mitochondria.
openaire   +1 more source

VDAC1‐Targeted NHK1 Peptide Recovers Mitochondrial Dysfunction Counteracting Amyloid‐β Oligomers Toxicity in Alzheimer's Disease

Aging Cell, EarlyView.
Amyloid‐β (Aβ) oligomers affect VDAC1 electrophysiology and the physiological metabolic cross‐talk between cytosol and mitochondria. The use of a small, synthetic VDAC1‐antagonist peptide, derived from hexokinase, restores mitochondrial functionality, and respiration in cellular models of Alzheimer's disease. ABSTRACT Mitochondrial dysfunction has been
Fabrizio Cavallaro, Stefano Conti Nibali, Salvatore Antonio Maria Cubisino, Pietro Caruso, Stefania Zimbone, Iolanda Rita Infantino, Simona Reina, Vito De Pinto, Angela Messina, Maria Laura Giuffrida, Andrea Magrì   +10 more
wiley   +1 more source

Supplemental epilactose prevents metabolic disorders through uncoupling protein-1 induction in the skeletal muscle of mice fed high-fat diets

British Journal of Nutrition, 2015
Y. Murakami, Teruyo Ojima-Kato, W. Saburi, H. Mori, H. Matsui, S. Tanabe, Takuya Suzuki   +6 more
semanticscholar   +1 more source

Age‐Associated Decline in Autophagy Pathways in the Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light‐Induced Outer Retinal Degeneration in Mice

Aging Cell, EarlyView.
Transcriptomic analyses reveal an age‐related decline in autophagy pathways in RPE/choroid. These pathways remain unchanged in early AMD but become bidirectionally dysregulated in later stages, along with increased RPE loss. Pre‐treatment with trehalose eyedrops enhances RPE autophagy flux and prevents light‐induced outer retinal degeneration in mice ...
Katherine Cox, Gongyu Shi, Neve Read, Mohamed T. Patel, Kepeng Ou, Zijia Liu, Jiahui Wu, Suci Cendanawati, Jenna Le Brun Powell, Pola Goldberg Oppenheimer, Lisa J. Hill, Lindsay B. Nicholson, Andrew D. Dick, Jian Liu   +13 more
wiley   +1 more source

ElixirSeeker: A Machine Learning Framework Utilizing Fusion Molecular Fingerprints for the Discovery of Lifespan‐Extending Compounds

Aging Cell, EarlyView.
ElixirSeeker is a machine learning architecture based on a phenotype‐driven drug discovery approach to screen lifespan‐extending compounds. By integrating molecular fingerprints, ElixirSeeker could maximize feature capture of lifespan‐extending compounds.
Yan Pan, Hongxia Cai, Fang Ye, Wentao Xu, Zhihang Huang, Jingyuan Zhu, Yiwen Gong, Yutong Li, Anastasia Ngozi Ezemaduka, Shan Gao, Shunqi Liu, Guojun Li, Hao Li, Jing Yang, Junyu Ning, Bo Xian   +15 more
wiley   +1 more source

Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion

Molecular Metabolism, 2015
S. Keipert, Maria Kutschke, D. Lamp, Laura Brachthäuser, F. Neff, C. Meyer, Rebecca Oelkrug, A. Kharitonenkov, M. Jastroch   +8 more
semanticscholar   +1 more source

MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2 [PDF]

, 2013
Sayantani Bandyopadhyay, Troy Lane, Venugopal Rajanbabu, Prasanna Tamarapu Parthasarathy, Young Cho, Lakshmi Galam, Richard F. Lockey, Narasaiah Kolliputi   +7 more
openalex   +1 more source

Brown and beige adipose tissue: New therapeutic targets for metabolic disorders

Health Sciences Review
Brown adipocytes constitute a specialized tissue in heat build-up (i.e., thermogenesis) due to their mitochondrial uncoupling capacity, as they express thermogenic genes, playing a role in the energy metabolism of the whole body in mammals through non ...
Bruno Souza Magro, Daniel Penteado Martins Dias   +1 more
doaj